Back To The Age Of The 80s

A relatively complete drug clinical specification is the basis of an efficient drug approval system.

In Li Zheng's last life, Hua Guo gradually established drug clinical trials standards in 1999, and the long and inefficient drug approval process remained unsolved until Li Zheng left.

"These are 20 drug samples I asked Xiao Lu in our laboratory to randomly sample on the market. They are common cold medicines and cardiovascular emergency medicines. Our laboratory has conducted a preliminary analysis of their ingredients and found a very Interesting things."

"Xiao Lu, tell the professors." Li Zheng winked at Lu Xuebei behind him.

Lu Keke does not have the talents of Meng Jie, nor the rapport of Sun Bin, but he is a good at data analysis.

Lu Xue looked a little nervous. Most of the people in this conference room, he had only seen it on TV before, and even on textbooks. He would never have dreamed that one day, these people would sit together and listen to him. .

Li Zheng could obviously hear Lu Keji's rapid breathing and swallowing hard. He stood up and patted his subordinates on the shoulders to signal him not to be nervous.

But obviously, Lu Xuexue seems to be more nervous.

You can't shame Professor Li, you can't shame Professor Li, Lu Xueqi repeated it several times in his heart, only to make his beating heart a little smoother.

He distributed the report in his hand to the professors present.

"Here are the test reports of twenty drug samples, as well as the clinical trial data of several related drugs that I can find." The sample test report was made by the Ninth Laboratory itself, while the drug clinical trial data is somewhat sensitive. It is not easy for Lu Xueke to obtain such a few pieces of data.

All the experts present were experts in the industry. After a glance at the test report, the meaning of Li Zheng's words became clear. The atmosphere in the conference room suddenly became depressed.

"Professors..."

Lu Xuexue finally did a good job of psychological construction and began to speak, but he was just starting to get started when he was interrupted by a furious voice.

"Naughty! It's totally ridiculous, this is a life-saving medicine! Don't they lose heart by doing this!" Old Yang couldn't help slamming the test report and clinical data on the conference table.

"It doesn't matter if you use synthetic vitamins as the main ingredient of cold medicine. What's the matter with this heart disease medicine? Is it enough if you can't eat people? This is totally joking with people's lives!" Old Yang flushed with anger.

In the 1980s when there were no clinical trials of drugs, it was not uncommon for vitamins to be used as cold medicines. As for this heart disease medicine, it was claimed to relieve early cardiovascular disease and dredge blood vessels. However, the ninth laboratory detected that it was The medicine contains trace amounts of iron, which is indeed beneficial to the heart, but the benefits are minimal at all, let alone alleviate early cardiovascular disease.

Talk about ideals first, and then pose questions. This is a skill commonly used in negotiations for later generations. It may not be suitable for later generations who are "experienced in the business", but it is surprisingly easy to use for these scholars who are obsessed with learning .

Many old professors made their judgments on the spot that this drug clinical trial specification must be established as soon as possible.

"Predecessors, the norms should be established as soon as possible, but how to build, how to build, how to proceed logically, without causing backlash, we need to take a long-term view." Li Zheng said with a smile.

In the short half a year since Li Zheng left, there has been no breakthrough in the "infinite time organ storage technology" experiment. Now as soon as Li Zheng comes back, this matter is on the agenda.

Although the accelerated approval time for erlotinib given by the FDA is 1-3 years, as long as the FDA confirms that erlotinib is clinically effective, the difficulties faced by the Human Genome Project will no longer be difficulties.

After the laboratory is built, the Human Genome Project, which is known to be juxtaposed with the Human Moon Project and the Manhattan Atomic Bomb Project, which is widely participated by various countries, can be officially launched worldwide.

And Li Zheng wants this time to drive out the project results of infinite time organ storage technology.

"No. 1 and No. 2 are ready to thaw." Li Zheng was dressed in a white lab coat, a white mask covering half of his face, revealing only two slightly squinted eyes.

"The equipment is ready."

"The test equipment is ready."

"The computer is ready."

"Okay, one, two, three, defrost!" In the two transparent containers in the laboratory, a lot of white liquid nitrogen gas emerged instantly, and the frost covering the storage organs melted at a speed visible to the naked eye.

"The container returns to temperature, and the temperature is tested to 12 degrees Celsius."

"The temperature test is 15 degrees Celsius."

The experimenter reports data every 30 seconds. When the environment in the container reaches the level of a simulated human body, the tester quickly measures the activity of the storage organ.

"The heart beats at 60 beats per minute, without any obvious abnormalities."

"The heart beats at seventy-six beats per minute, no obvious abnormality."

"The heart beats at seventy-three beats per minute, there is no obvious abnormality."

Sun Bin’s voice faintly trembled when he reported the data. This was the first world-class big project he had participated in. Even if everyone told him that he was about to participate in the greatest biological project in human history, but it was not "Unlimited time organ storage technology" he still has a special "first love complex".

This kind of plot becomes especially obvious when the experimental results are about to be published.

Ten minutes passed.

Half an hour passed.

The heart is beating normally!

The hearts of everyone in the laboratory seemed to be jumping out of their mouths. They dared to swear that their hearts were beating much faster than the heart in the container.

For the next forty-eight hours, they stared at the data on the computer screen without blinking. Lu Kee's hands danced quickly on the computer keyboard, and beautiful data lines appeared on each screen following his movements.

Forty-eight hours later, until the two hearts stopped beating, their hearts continued to move at a high frequency. Sun Bin clutched his chest and said in a daze: "We... succeeded?"

In the simulated human environment, the maximum storage time of the heart will not exceed forty-eight hours.

And from the data collected so far, the effect of storage for a small half year on the activity of the heart is almost negligible. According to this degree of influence, under the technology of the Ninth Laboratory, the storage time of a heart can be as high as 70 years. the above.

This cannot be regarded as an infinite time storage in the rigorous text description, but in current science, it can already be called that.

A heart can be stored for more than 70 years. According to the current national organ donation situation, Lu Xue calculated that as long as the storage time of a heart can reach more than 40 years, then the patient's needs and the heart supply can be balanced.

And the scope of application of this technology is not just the heart, liver, kidney, and even the human brain.

Many biological scientists in the world have proposed human brain transplantation, using human brain transplantation to realize human immortality. The technology of human brain transplantation can be realized theoretically. The only problem is the sophisticated brain organ and brain storage technology.

The infinite-time organ storage technology of the Ninth Laboratory completely solves the latter problem.

"Well, it worked." Li Zheng let out a long sigh of foul breath.

The combination of organ regeneration and unlimited storage of organs will be the epitome of future medical treatment. In the last life, because various patents were in the hands of various institutions, even if the two technologies were realized, there were almost no clinical applications and joint practices.

To be honest, while protecting the enthusiasm of researchers, patent rights do hinder the progress of medical science to a certain extent. In this life, he might be able to heal this regret.

"Professor, did we really succeed?" Sun Bin always felt that he was still in a dream.

Li Zheng was dumb.

"You have finished writing your papers. When the project papers are published, your papers can be published one after another. If you write well, I will recommend you to Cell."

""Cell"! The "Cell"? "Cell"?!!!" Sun Bin opened his mouth wide.

"I...I'll go back and write! Right away! Right away!" He jumped up from his seat suddenly, ran to the lounge next to him, and turned his head while running, and said loudly: "Professor, you can speak To count! Cells, cells!"

"Science", "Nature", and "Cell" are the top three major journals in biology. Those three journals published in China in the 1980s can be counted with one hand.

Before Sun Bin was even surprised, he ran into the lounge and took out the half-written essay, smirking while writing, "Cell".

Meng Jie and Lu Xueke stood there and stopped talking. Although their performance was a little better than Sun Bin, their inner excitement was not less than that of him. You can see their trembling hands.

Li Zheng chuckled, "Go, go, let them do the rest." Li Zheng pointed to them, naturally the two Huaqing students who helped.

Now the envy and jealousy in their eyes is almost hard to express in words. It is indeed the ninth laboratory.

After finishing all the experimental data, Li Zheng called Liu Sichao and unceremoniously pushed him the work of writing the thesis. Liu Sichao's project can be considered from beginning to end. The writing of the paper is not difficult for him.

Moreover, Li Zheng intends to give him a co-first author, so throwing the package is even more burdenless.

And he himself is going to set out to promote the establishment of Huaguo's drug clinical trials.

As he said at the meeting, the norms should be established as soon as possible, but how to build them, how to build them, and how to proceed logically without causing any backlash. This requires long-term consideration.

In fact, Li Zheng had already thought about this issue when he decided to return to Huajing. After a year, the plan in his mind became clearer.

Although the drug approval system is related to the biological circle, it is more of a political aspect, and political incidents must be dealt with by political methods.