Doctor: It's reasonable to perform surgery on yourself.

If it is so easy to do, why does a box of sorafenib, which sells for 25,000 yuan, still sit firmly on the throne of the "miracle drug" and remain standing?

and……

Even if you spend more than a billion dollars to make it, sorafenib has already made a lot of money with its early high pricing.

At this time, it quickly cut prices and started a price war. No one could compete with Sorafenib, which had firmly controlled the liver drug market.

However.

It would be completely different when the person who said this was Xu Qiu, who had once defied foreign countries' "six millimeter artificial small blood vessels is an insurmountable theoretical limit" and created Linhai small blood vessels with incredible speed and technology. .

He once broke many foreign blockades and developed six-millimeter small blood vessels using old machines that were eliminated seven or eight years ago. He also turned his offensive and monopolized the world, charging patent fees from all over the world... Now he has announced that he will create a pharmaceutical industry. A miracle, who dares to say it’s impossible?

What's more, the artificial blood vessel expert group here in Daxia only allocated Xu Qiu a few million in scientific research funds for the patent... In the end, Linyi and Baiyun Province paid 600 million out of their own pockets to prevent Linhai's small blood vessels from being buried.

This time, no matter what various experts say, the Minister of Health and the Director of the National Health Commission cannot believe it.

…

"In terms of funding, you can just mention it, and I will help you negotiate with the Health Commission." The Minister of Health said with excitement.

The director of the National Health Commission also nodded: "You don't need to worry about funding. In addition, you can apply to us for any domestic pharmaceutical company you like or who you want, and we will transfer anyone you can get. ...but three years at most!”

Although the two are national-level bosses with the qualifications to dispatch various medical talents in the country, different provinces are not an iron bucket. Different pharmaceutical companies have their own scientific research teams and compete with each other.

Recruiting a few talents for two or three years is not a big problem, but if we really give all the people to Xu Qiu, we will protest next.

"In terms of funding..."

Xu Qiu thought about it for a long time and said: "I'm not sure about this, but a conservative estimate is that it is around 5 billion Daxia coins."

"What?!"

The Minister of Health and the Director of the National Health Commission looked at each other and saw the shock in each other's eyes.

five billion?

The average R\u0026D cost of a new drug alone is billions of dollars.

Take Liver Anning as an example. Huining’s direct expenditure for this was as high as 1.43 billion RMB. Adding in capital time and opportunity costs, the actual expenditure was actually as high as 2.58 billion RMB.

Converted, that’s nearly 15 billion Daxia coins!

This amount of money is actually not much, even below the average.

Last year, the National Center for Food and Drug Administration announced the launch of several new drugs. Among them, AstraZeneca had a total of five drugs approved, with a total R\u0026D expenditure of 59 billion, and the R\u0026D cost of a single new drug was 110 billion. Eight hundred million dollars.

GlaxoSmithKline Pharmaceuticals' research and development costs for a single drug are 8.2 billion yuan.

Amgen Pharmaceuticals, which ranks tenth in R\u0026D expenditures, has R\u0026D expenditures of up to 3.7 billion yuan for a single new drug. Huining's Hepatopacifier, which was produced a few years ago, is not even ranked in the top 20!

This is actually the biggest reason why it dares to price the product at 61 yuan - because the research and development funding of more than one billion yuan is really too shabby and the cost is too low.

But now, Xu Qiu came up with a more terrifying number.

Five billion Daxia coins!

That’s less than 900 million RMB!

"Every year?" The Minister of Health couldn't believe it and added: "Five billion a year?"

Xu Qiu thought for a moment and nodded: "It can be understood that way."

The minister immediately breathed a sigh of relief: "Let me tell you, five billion per year is considered a normal level, otherwise Berry Countryman will be scared to death."

The director of the National Health Commission added silently: It almost scared me to death.

But at this time, Xu Qiu paused and said: "My plan is to develop new drugs within a year, so it can indeed be understood as five billion per year."

"???"

"You...what did you say!?"

At this moment, no matter how big their hearts are, the minister and the director cannot calm down...

In one year, a total of five billion can produce a real "liver tranquility"!

Even in their dreams, they would not dare to think so!

"He...he can't really do it!" The minister looked at Xu Qiu blankly.

Thinking that Xu Qiu only spent 600 million to develop the Linhai small blood vessel with seven or eight years of obsolete foreign equipment, the minister suddenly felt that Xu Qiu could really do it.

But it was precisely when they thought about this that they found it even more unbelievable.

This is a new drug...

"How...how is it possible?" The director of the National Health Commission also found it difficult to accept.

Although they hope that all this is true, they have even negotiated with the country to slowly get more than 10 billion for Xu Qiu to do research and development, and they have planned to protect Xu Qiu in the next few years to prevent all walks of life from He exerts pressure that affects his R\u0026D status.

However, when the other party told each other about five billion expenses in one year, the two of them still felt it was too dreamy...

Xu Qiu thought for a while, calculated an account, and said: "Generally speaking, most of the cost of new drug research and development is wasted on trial and error. Thousands of compounds, tens of thousands or even more combinations, there may be only one Ten options were suitable, but in the end only one met the requirements.

"But if the last step is reduced from one-tenth to one-fifth, and the research and development costs of five failed drugs are reduced, five billion is theoretically feasible."

"..."

"Wait...what are you talking about?"

The Minister of Health and the Director of the Health Commission were both stunned.

They were absolute laymen in drug development and knew nothing about it. Their only role was to act as Xu Qiu's ATM machine, giving money and people... But they understood what Xu Qiu said.

Reduce the R\u0026D cost of failed drugs...

This is indeed an effective way to reduce R\u0026D expenses, but the key is, if you don't study it, how do you know it will fail?

Just like eating ten buns to be full, Xu Qiu's words are like eating the tenth bun directly... How can you eat the tenth bun directly without eating the previous nine buns!

However, Xu Qiu had a natural expression...

It was obviously Xu Qiu's words that were illogical, but in the end the Minister of Health and the Director of the Health Commission began to suspect that there was something wrong with them.

Xu Qiu seemed to realize that he was a little too confident. He hesitated and added: "Of course, it is very difficult to directly save the cost of five failed drugs..."

The two national leaders were about to breathe a sigh of relief, "That's right" before they said it, but Xu Qiu said again: "So, consider saving the R\u0026D funds of four failed drugs out of ten compounds."

"..."

Fuck... Is this reasonable?

The minister and the director fell into silence. Their brains could no longer keep up with Xu Qiu's thinking.

First this, then that, and then you can directly save costs. If you follow Xu Qiu's logic, it seems to be really simple... It's over, it feels like I need to grow a brain!