Doctor: It's reasonable to perform surgery on yourself.

Or to put it more bluntly, the Ministry of Finance has no control over how to spend the five billion. They just help Xu Qiu keep the books. In the end, Xu Qiu alone has the final say.

"Doctor Xu, five billion is a lot, but if everyone adds a few hundred yuan, it won't be expensive... We still have to save money!" The director of the Ministry of Finance quickly advised with a few drops of sweat on his face. .

Xu Qiu thought for a while and nodded.

The financial director was about to breathe a sigh of relief when he heard Xu Qiu say: "Then the increase will be less."

Part of the 5 billion budget is specially prepared for the high salaries of researchers...

Just like it was at Linhai Artificial Vascular Research Institute.

Working in Xu Qiu's hands, the workload will definitely far exceed the average level in the industry, and accordingly, the salary will be very high.

Needless to say, dedication to the advancement of human medicine. This sentence is noble when used to restrain oneself, but it is despicable to impose it on others.

What Xu Qiu can do is to provide a salary that matches the workload. If the money is enough, the employees will beg the boss to use them like beasts...

"The second tier, from thirty thousand to forty-five thousand."

"The third level increases from an average of 15,000 to 23,000."

"Researchers at all levels will receive a general salary increase of 10,000 yuan!"

"In addition, as long as a certain team produces major results, they will be awarded bonuses ranging from 500,000 to 1.5 million depending on the importance!"

As for academicians... People at this level no longer care about the salary. The resources they control are unimaginable to ordinary people. Money is just a number to them. What makes them more excited is to personally participate in a great project.

Entering the annals of history is their greatest pursuit.

When Xu Qiu announced the salary increase, the finance director was completely dumbfounded.

Is there such a salary increase? It can easily increase by 10,000 to 10,000 yuan. The salary level of researchers in the new liver drug department is already very high, but they need a huge increase!

Working in the new liver medicine department for half a year is almost the same as two or three years in the original unit!

and.

Nowadays, the industry is generally involved in involution, and the work pressure is increasing. Wherever it is not 996 or 007, I have never seen anyone take the initiative to increase wages for employees...

"Dr. Xu..." The financial director hesitated. Although the salary system of clinical doctors was also drastically reformed by Xu Qiu, and doctors' salaries were also higher, he still felt that the salary increase in the new liver drug department was too outrageous.

Xu Qiu shook his head and interrupted him, saying: "No need to say more, just go and execute it."

"Yes..." The financial director also knew Xu Qiu's character and did not refute.

The next day, a salary adjustment announcement was released and sent to the mobile phones of all researchers.

For a time, Baiyun Drug Research and Development Institute was extremely quiet.

Everyone stared at the text messages in their hands with incredulous eyes...

"Another salary increase?"

"My salary is much higher than that of my original employer, and the work intensity is actually about the same as before, but now I'm getting more money?"

"Is this the treatment that Linhai Artificial Vascular Research Institute received a few years ago? I finally understand why those people were so devoted to Xu Qiu back then!"

"Where to do scientific research is not 996 or 007, but Dr. Xu has enough money here!"

"Overtime pay is three times on weekdays and five times on holidays. This is free money!"

"Can you add a bed to the laboratory? I suddenly feel like I am at home..."

"With a monthly salary of 23,000 yuan, my life belongs to Dr. Xu!"

The researchers all went crazy.

In their original unit, the salary was only 11,000 or 12,000, but now it has almost doubled. Although the workload is amazing, it is not much different from before.

At this moment, no matter what Xu Qiu's status is, whether he is a genius in the medical field or a scientific research genius, he is a god in the eyes of researchers!

Researchers are human beings too, with parents and children to support. Most of them have mortgages and car loans. After working for Xu Qiu for the past six months, they will no longer have to worry about various loan repayment pressures in the next few years!

This does not include the various bonuses in the project.

And after the research and development results, everyone will receive huge rewards!

"Doctor Xu, please don't treat me like a human being!"

"Let's work hard. As long as the project is successful, we will have a solid job for the rest of our lives. We will not be short of money!"

"Working overtime, I will study the discoidal domain receptor 1 today!"

"We must produce some important results. If we get a bonus of 1.5 million, our team will take off immediately!"

…

Two weeks later, a complete target research report was sent to Xu Qiu.

After countless desperate efforts, eleven of the potential targets provided by Xu Qiu were confirmed to be of research and development value.

The first is CRM197.

The second one, DDR1, also known as Discoid Domain Receptor 1, is up-regulated in hepatocellular carcinoma tissues, and its expression in stage II-IV hepatocellular carcinoma tissues in the TNM tumor staging system is higher than that in TNM tumor staging system. Expression in stage I hepatocellular carcinoma tissues in the tumor staging system, and high expression of DDR1 is associated with poor prognosis.

Moreover, the R\u0026D Institute has the most in-depth research on DDR1. Now it has discovered the interaction mechanism between DDR1 and AFR6, confirming that DDR1 and ARF6 can be used as new prognostic markers and therapeutic targets for metastatic liver cancer.

The second is cofilin phosphatase 3, SSH3, which plays an extremely important role in the occurrence of liver cancer, especially in hepatocellular carcinoma. SSH3 is positively correlated with pathological stage and tumor size...

There is also CBX6, which is chromatin-binding protein 6. Multifunctional analysis showed that its elevated expression in hepatocellular carcinoma is an independent adverse prognostic factor.

More importantly, once overexpression of CBX6 is found in patients with hepatocellular carcinoma, they basically have the characteristics of rapid tumor growth, strong invasiveness, and high clinical stage...

This means that CBX6 may be closely related to the progression of liver cancer.

Subsequent targeted studies concluded that CBX6 can enhance the invasion and metastasis capabilities of liver cancer cells by regulating the epithelial-to-mesenchymal transition mechanism mediated by the transcription factor Snail/ZEB1!

And this almost puts a perfect target in front of everyone - as long as CBX6 can be inhibited, the occurrence and development of liver cancer will be greatly curbed!

In addition, there are steroidal 5α-reductase 3 (SRD5A3), myotubulin-related protein 14 (MTMR14), inhibitor of differentiation 1 (ID1), pescadillo ribosome biogenesis factor 1 (PES1), etc...

These targets all have their own advantages. Some are more suitable for affecting the proliferation and tumorigenesis of liver cancer, some can play an important role in blocking tumor development, and a few are particularly effective at inhibiting liver cancer metastasis.

"It's a Chinese New Year in the field of liver cancer drug research and development..." Mo Wan's eyes widened as he looked at the documents on Xu Qiu's desk.

When did new targets become so easy to find?

Other pharmaceutical companies often spend a lot of money, countless manpower, and months or even years to find an effective target for a target.

It only took Xu Qiu a month to screen out eleven targets with great potential...

If nothing else, even if Xu Qiu's research is suspended, he will still make huge profits!

If these targets were sold publicly, each one would be worth a sky-high price!