Enter the Immortal Cultivation

In the history of the auraless universe earth, the discovery process of prions was extremely tortuous.

In fact, the first disease studied that uses prions as pathogens and can infect humans [human prion disease] was discovered as early as 1955. At that time, an American explorer and doctor named Gadacek discovered this disease when he was investigating a primitive tribe with cannibalistic customs in the eastern highlands of Papua-New Guinea.

The American doctor has even concluded that this disease called "Kuru" was caused by the cannibal tribe eating the brain marrow of dead relatives.

He used chimpanzees as experimental animals, diluted the brain tissue homogenate obtained from the death of Kuru patients, and injected it into the chimpanzee.

After that, he used physical means to separate larger bacteria and parasites, and killed nucleic acids by ultraviolet rays to determine the pathogen of Kuru.

He even tried to use protease to treat these homogenates.

Of course, there is no doubt that protease completely deprived these homogenates of their pathogenicity.

However, his first reaction was... well, it must be that the protease destroyed the shell of the "Kuru virus".

This should be a new type of virus.

At that time, this idea was very natural - it is better to say that almost all scholars would think so.

When Gajdacek discovered kuru and issued an inaccurate... no, it can even be said to be "wrong" conclusion about it, Prusiner, who later discovered prions, had just entered middle school.

And this achievement made Gajdacek win the Nobel Prize in Physiology and Medicine in 1976.

In childhood, Prusiner was still wondering whether to use hamsters with an incubation period of only 100 days instead of mice with an incubation period of 200 days.

In addition, by the way, the first prion disease that can infect humans discovered by humans was "Creutzfeldt-Jakob disease" discovered by two German doctors, Hans Kreuzfeld and Alphonse Jacob, in 1913.

It was only after he witnessed one of his patients being tortured to death by Creutzfeldt-Jakob disease in 1972 that Prusiner chose to study scrapie, which has similar symptoms to Creutzfeldt-Jakob disease and mad cow disease.

Between 1913 and 1997, scholars on Earth still had many opportunities to conclude that "prions are special pathogens."

However, until 1996, when the UK unexpectedly experienced an outbreak of mad cow disease due to the large-scale use of bone meal from dead beef, Prusiner's views were not recognized by others.

In fact, after 1997, the entire academic community's attitude towards Prusiner was only "reluctantly accepted."

Even in 2001, a major achievement in prion research stated in a journal that "the results will strongly support Prusiner's hypothesis - Prusiner won the Nobel Prize in 1997 for this hypothesis."

On June 14, 2001, a news item was published in Nature magazine. Serono announced that the research team led by Dr. Claudio Soto at its Serono Pharmaceutical Research Institute has developed a technology to detect abnormal prion proteins.

To be precise, it reproduced the replication process of prions.

Protein misfolding cyclic amplification technology, referred to as PMCA.

Song Shufu will never know how many difficulties he has overcome in this poverty.

Song Shufu's decades of research alone is equivalent to eight years of accumulation of Prusinna on Earth. With Song Shufu's foundation, Ai Qinglan was able to complete this research in a short time.

And now, Song Shufu's last bit of luck has made Ai Qinglan make a powerful leap.

If there is no unexpected discovery, then at least in the next few decades, Ai Qinglan will need to continue to run for this "hypothesis".

Of course, "saving decades of effort" does not mean that decades of problems are solved in an instant.

In fact, this does not mean "the end". There are still many problems facing Ai Qinglan.

Of course, compared with her counterparts on Earth, Ai Qinglan is undoubtedly much luckier.

Regarding the mechanism of prions, the version proposed by Prusiner in 1995 is the most promising in the academic community on Earth. Claudio Soto completed the PMCA technology based on Prusiner's conjecture and the idea of ​​PCR.

Ai Qinglan directly discovered such a strange phenomenon - she can directly infer the "principle" from the phenomenon.

"Why is it like this?" Ai Qinglan whispered.

"Water flows to lower places" because of "gravity", and the reason why "gravity" exists is because of "universal gravitation", and the source of gravity is "the curvature of space-time caused by mass". The source of "mass" is what we will study next.

No "phenomenon" is taken for granted. Even if it seems to be so taken for granted.

Under "taken for granted" is the "Tao".

Ai Qinglan wants to think about why the pathogenic creature source can be amplified after ultrasonic treatment?

Why is it completed in the water bath of reverse transcription polymerase chain reaction?

What kind of changes have occurred in the pathogenic creature source after ultrasonic treatment?

What kind of process does the normal life essence go through to be transformed into the pathogenic life essence?

Why does this process not require enzyme catalysis?

What is the mechanism of action of the pathogenic life essence...

Also - is it considered a "living creature" in the conventional sense?

All of these are problems.

"It is necessary to reset the evidence." Ai Qinglan said this and quickly wrote on her notepad.

Demonstration on repeating that operation at different temperatures.

Evidence for repeating that operation under different intensities of ultrasonic treatment.

Demonstration of repeating that operation with different durations of ultrasonic treatment.

Demonstration of repeating that operation using different amounts of disease-causing primordial templates.

Evidence for repeating the operation after changing the buffer composition.

about……

There are too many empirical evidences that can be thought of in an instant, and countless inspirations are stirring in Ai Qinglan's mind at the same time.

It can be seen that for a long period of time, this empirical department... no, it may not be the only empirical department. Ai Qinglan's energy is enough to influence many empirical departments. And if the Spiral Twins can recognize him, then there are many empirical departments under Jiyingu who will do relevant verification. In short, relevant empirical evidence will not stop for a long time.

However, the development of misfolding cycle amplification technology of living matter means that the results that used to take months can now be obtained in just a few hours.

This is simply a first-class magical method!

Just when Ai Qinglan was enthusiastically demonstrating her design, Chen Feng walked up and said to her: "Sister Lan, I know you are very happy, but now we have other procedures to run..."

………………………………………………………………

The outer door notification system is a special system recently implemented in China.

The core content of this system is only one thing - when a monk makes a subversive achievement, he has the responsibility to inform the leaders of the Immortal Alliance of other sects first.

A few years ago, the large-scale incident of Wanfamen going crazy caused by "incompleteness" is still vivid in our minds. Many skills of the Immortal Alliance were on the verge of stopping for a while, and many high-level monks' bodies were unstable, and even their lives could not be guaranteed.

This is the result of the preparations made in advance by many Wanfamen monks, including the national player Feng Luoyi and the master Turing.

In recent years, a new generation of monks has gradually emerged, subverting the past much faster than before. The most typical one is Wang Qi, but Mi Tianzhao and other monks also have this type of sign.

There are even frightened old men who suspect that these younger generation of monks will directly kill the human race before powerful foreign enemies attack.

Therefore, after the large-scale incident of Wanfamen going crazy, the Immortal Alliance also established an outer sect notification system in addition to a similar peer review system.

If you have made a disruptive achievement, you should first notify the senior leaders of other sects.

Feng Luoyi was more or less unhappy about this.

Because in most cases, this "senior in other fields" is probably him.

However, the direct cause of this system is his own apprentice, so he still has to consider whether it is appropriate to bear this responsibility.

And now, his brain hurts even more.

Because the report he received this time was that "this discovery is equivalent to shaking the status of the Theory of Heavenly Evolution in the way of life."

What is the status of Tianyan Theory? For some modern Dharma practitioners, it has almost reached the level of belief.

Although the Theory of Heavenly Evolution itself has been revised many times after the theories of inheritance and bloodline roots were put forward, these revisions are only to refine and correct it, rather than to "shake it up".

It would be okay if someone else wrote this, because since the emergence of the "outer sect notification system", the Immortal Alliance has always received three or five reports from the Immortal Court disciples and even people from the side sects overturning the Tao of Xiangxing every now and then.

However, this report is different when the name "Ai Qinglan" is added.

Let's put it this way. If someone else came over and said that they wanted to overturn the logic, Feng Luoyi would just laugh it off. But if Wang Qi said this, Feng Luoyi would kill the traitor with one sword.

He had to pay attention - otherwise, Tianling Ridge would directly suffer a catastrophe.

However, when he actually listened to Chen Feng's narration, he felt like...well, how should I put it, that kind of "nothing more than that" feeling.

——In this way, it can be regarded as "equivalent to shaking the theory of Tianyan"?

Although every empirical department has some elements of boasting and needing funds, aren't you a little over the top when it comes to playing like this? Do you want to be so exaggerated?

Why can't it replicate itself at such a young age?

Chen Feng was a little anxious. He really didn't know how to describe the significance of this discovery.

Ai Qinglan on the side opened her eyes: "Senior Feng, please let me explain the follow-up matters."