Genius of the Rules-Style System

Zhao Yi is not interested in small projects in the laboratory, but he is still very concerned about the 'anti-infection' problem that was accidentally discovered during the experiment, because the research on 'anti-HIV infection' is very valuable.

The samples made from the blood provided by Fan Lei had obvious ‘anti-infectious properties’, but the only conclusion drawn during the research process was that ‘a certain infection-related antibody protein is at work’.

This conclusion is too broad.

Some kind of infection?

There are simply too many pathogens in humans, and the scope of 'a certain infection' is too wide, but the changes to the samples have stagnated. It is impossible for a single sample to support continued research, and it is too difficult to find out the cause.

Therefore, at the beginning, Ai Lixin, Zhang Wei and others suggested that Fan Lei should be injected with conventional viruses and bacteria, which made sense.

This sounds a bit scary, and reminds me of some scientists who conduct human experiments, but in fact, many studies in medicine require ‘volunteers’.

The former is 'human experiment' and the latter is 'volunteer', but the actual meaning is the same, both are experiments on humans.

"You definitely don't want to be a volunteer, and it's very inefficient."

Zhao Yi and Fan Lei explained seriously, "Even if you are equal, it will probably be difficult to study because there are too many pathogens."

"Sister Zhang Wei's idea is to start with experiments. Use the original sample as a carrier, add your blood, and then do a microbial invasion experiment for observation."

"There are many problems with this method. Because there is no support from the human body's circulation, if the blood alone is invaded by microorganisms, the immune response will be very weak, and it is difficult to detect it."

In two years of college, he has completed several projects, and Zhao Yi has improved a lot. Basic knowledge is still on the one hand, and he has a certain understanding of various detection, analysis, and experimental methods.

"But there is no other way." Zhao Yi said thoughtfully, "Once the sample loses its research value, we can only stop it."

"But that's the way research is, some get results and some don't."

Zhao Yi sighed.

In fact, he was trying to persuade Fan Lei not to be too resistant to 'drawing blood'. As he talked, he felt that the research had no results, and he still felt a little depressed.

If the same words were said to Li Renzhe, the latter would probably say excitedly, "I'm not afraid!"

"It doesn't matter if you contribute a little blood to science!"

Fan Lei was not easily 'fooled', he was just not very resistant and said plaintively, "I have no choice anyway, right."

Zhao Yi nodded, "That's okay."

…

Drawing blood is not that scary.

Fan Lei was a little worried before going there, but he was no longer worried after receiving the order from the institute. Director Yu, who issued the order, gave him some common sense about 'blood volume'.

When normal people go for a blood test, even if it is a major blood test, they usually draw about 15 ml to 30 ml, usually divided into 3 to 5 tubes.

The tube may seem quite small, but in fact it is only a few milliliters.

When blood is drawn during a blood test, you will definitely not feel much. Most healthy people will not feel it. It is almost the same whether it is drawn or not.

Fan Lei's list marked '100ml', which means he had to go to the hospital to draw 100ml of blood and bring it back.

100ml of blood is much more than the blood test, but it is lower than the 200ml standard for blood donation. For healthy and strong young people, it will not feel much at all. The feeling is probably due to the psychological effect.

Obviously.

Fan Lei is a healthy and strong young man.

"If you feel dizzy after smoking, it must be psychological."

Director Yu said affirmatively.

Fan Lei suddenly felt relaxed. On the way, he was still thinking about finding a familiar nurse sister to help. There were a few whom he had a good relationship with last time, and he even got their phone numbers.

…

When Fan Lei went to the hospital to draw blood, Zhao Yi had already come to the laboratory and talked with Zhang Wei about the experimental design.

Zhang Wei didn't just want to separate the experiment. She had already thought about it and even discussed it with Ai Lixin, but she never put it into practice.

One is that the laboratory has other projects to do and is too busy to take care of them.

The second is that conditions do not allow it.

Mixing samples and blood, simulating a certain environment to invade external bacteria and viruses, and producing antibody proteins may sound easy, but in fact, just establishing a "certain environment" is not easy, let alone Said that the sample also needs to be allowed to produce antibody proteins.

You know, blood alone does not have the support of the 'human circulatory system'.

If you want to make individual blood produce 'antibody proteins', you not only need to simulate the environment, but also need to add a lot of materials and very harsh equipment conditions.

After the HIV virulence gene project was completed, the institute provided a large amount of funds specifically to improve the conditions of the laboratory. The laboratory did not purchase any more large-scale equipment, but instead refurbished various experimental tools, small equipment, reserve materials, etc. A comprehensive upgrade of the new generation.

When Zhao Yi entered the laboratory, he found that everything was different. He actually knew that the laboratory upgrade was funded by the institute, and he asked with interest, "How much did it cost?"

"More than three million!"

Zhang Wei smiled and said, "Don't look at it, just change it to something small, it will be more expensive than the big one!"

This is true.

In fact, just like a family, the cost of purchasing a few high-end furniture, electrical appliances and other large items is indeed quite high, but if you live a more refined life, the cost is no less than a few high-end furniture and electrical appliances.

There are too many objects in the house.

Everything from tables, chairs, benches, tile floors to tablecloths and towels has a price. The price of a tablecloth can easily vary several times. Buying the best for everything will add up to a scary amount. .

"After the laboratory upgrade is completed, we have the conditions to study the samples separately." Zhang Wei said with some anticipation, "We just need some blood. I haven't told Fan Lei yet..."

"Don't worry, I've asked him to take blood. He will probably be in the hospital by now." Zhao Yi said with a smile.

"That's good!"

Next, Zhang Wei began to talk to Zhao Yi about the details of the experimental design.

For example, how to simulate the environment, what materials to add, how to mix blood and samples, and some operational details, etc.

Zhao Yi listened carefully and took notes carefully.

These are the accumulation of basic knowledge and experience, especially some issues that need attention. What is taught in class is definitely not comprehensive.

After Zhang Wei finished speaking, she asked Zhao Yi for his opinion.

Zhao Yi waved his hand and said, "No need, Sister Zhang Wei, just make your decision."

"I trust you."

Zhang Wei nodded and continued working, unable to help but smile.

This is what she likes most about Zhao Yi.

If it were another laboratory, reporting the experimental design content to the researcher, even if there were no problems, they would definitely receive a few words of 'guidance'.

Dai Tianqing is like this.

No matter what kind of experiment he is doing or how perfect the design is, Dai Tianqing will always give his own opinions and ask a few questions about small details, which feels a bit like a review.

Zhao Yi is different.

He never got involved in designing experiments. It was because he didn't understand it at first. Now he must understand a little bit, but he doesn't know how to point fingers.

Zhao Yi didn't have any ideas. He did know a little about experiments, but he felt that he was not as good as Zhang Wei and others, so there was no need to give any advice.

He is very clear about his role in the research, which is to observe the experimental process and analyze the results.

In the design stage of the experiment, other people have more experience, and no matter how perfect the experimental design is, it may not be effective, and there is absolutely no need to do anything.

At eleven o'clock, Fan Lei returned to the laboratory.

Zhang Wei saved the blood samples and began to design experiments. She divided the samples in the culture tank into six parts, and then combined them with Fan Lei's blood to conduct routine virus and bacterial invasion experiments. The selected viruses and bacteria were all It is the most susceptible type of infection in the human body.

In the process of designing the experiment, Zhao Yi suddenly asked, "What would happen if the original sample was not added?"

"It's just normal immunity, right? But the immune response will be very weak. Reactive samples obtained after the experiment will not have any effect at all." Zhang Wei turned her head and explained.

The effect she said is 'anti-infection' against HIV.

If there is no obvious 'anti-infection' effect, it cannot be detected at all, and the experiment will be meaningless.

"unless."

Zhang Wei glanced at Fan Lei and did not continue speaking.

This time Fan Lei understood. His face turned pale with fright, and he repeatedly waved his hands to emphasize, "I am not a guinea pig!"

"Haha, what are you afraid of!"

Zhao Yi had no intention of letting Fan Lei be a guinea pig, because there were too many infection experiments to be done, and it was impossible for Fan Lei to be infected with each bacteria and virus one by one.

That's a bit...

Ahem.

Even if you are doing medical-related research, you must follow the humanitarian spirit!

"How about this!"

Zhao Yi thought about it and said, "Do a few experiments without adding the original sample. Maybe it won't work, but what if something is discovered? Anyway, our laboratory now has the conditions."

"……All right."

Zhang Wei thought for a while and nodded in agreement.

Nowadays, the laboratory is indeed equipped, but doing the laboratory also has consumption. The consumption of each experiment is not small. For a set of anti-infection experiments like this, the cost of maintaining it can easily reach several hundred yuan a day, or several more. If the group is put together, and there is an observation period of ten days or half a month, there will definitely be no more than 20,000 to 30,000 people.

Zhao Yi's words cost tens of thousands more experimental funds, which would be a real loss for a small project.

Now the laboratory has done many large projects, and independent projects are also paid for by the research institute. As long as there is a normal and reasonable expenditure report, the finance department will pay directly.

Don't worry about this.

Although Zhang Wei still felt that it was a waste and there would be no results at all, Zhao Yi's decision was the most important. Even if it was a wrong decision, director Yan Xuelin would probably think, "It's worth helping Zhao Yi learn a lesson from failure." Got it!"

So, it doesn't matter.

Of course.

There are other costs associated with this decision. For example, if Fan Lei's blood is used as a 'material', a few more portions will be used as samples. One hundred milliliters does not seem to be enough.

Zhang Wei looked at Fan Lei again and shouted, "Fan Lei."

Fan Lei didn't know much about research. He only heard Zhao Yi say that he needed to do a few more sets of experiments. He thought it had nothing to do with him and asked inexplicably, "What's wrong? Sister Zhang Wei?"

"How about you draw some more blood? It doesn't need to be too much, just fifty milliliters."

Fan Lei looked at Zhao Yi with a confused look, as if seeking support.

Zhao Yi spread his hands to express his innocence, and then whispered, "This time it's Sister Zhang Wei. It has nothing to do with me."

"……Yeah?"

Fan Lei thought carefully about the conversation just now, and a suspicious look appeared in his eyes. He still didn't find the problem, but he always felt that the matter was inseparable from Zhao Yi.

He took a deep breath and said depressedly, "It doesn't matter if you draw some blood. I'll just treat it as a blood donation... But will it be paid?"

"OK!"

Zhao Yi thought about it and called Liu Chengjie, "Brother Liu, help me apply for a blood donation subsidy!"

"Okay!"

…

In the end, Fan Lei did not escape the fate of "donating blood" too many times. He felt like a tragedy because he worked in a laboratory and became a guinea pig.

However, there is no way, men just have to be cruel to themselves sometimes.

He couldn't bear to work in the laboratory.

This 'part-time job' is really great. After the laboratory completed the HIV virulence project, Director Yan Xuelin promised last time that he would be allowed to work part-time as a contract worker.

Even though he is just a contract worker, it is amazing. You have to know that the people with the same salary are all doctoral students in the field of biomedical research. He knows nothing and can only do logistics work. He can sign a formal work agreement with the research institute. It's very respectable to say.

Besides, it’s money.

Since he came to work in Zhao Yi's laboratory, his income has greatly increased. He is basically not short of money. He can not only earn tuition and living expenses, but also a large surplus.

So, donating some blood is nothing in comparison.

Of course, when you think about it, this is indeed the case. Faced with "almost being used as a test subject" and having to draw blood several times for the experiment, I must still feel a little depressed.

afternoon.

Zhao Yi saw Fan Lei again and found that he was still in a state of resentment. He smiled and 'comforted' him, "Isn't it just to give out some blood? What's the big deal? People donate blood at a time of 400 milliliters."

"I'm not donating blood for free!" Fan Lei retorted depressingly.

"same."

Zhao Yidao, "Just treat it as a paid blood donation. If our research yields results, I guarantee you a share of the bonus."

"real?"

"I can still lie to you!"

"How much bonus can there be?"

"It's hard to say." Zhao Yi said somewhat mysteriously, "Maybe it's a number you don't dare to think about."

"Yeah……"

Fan Lei immediately thought about what the 'dare not think' number was, and he was somewhat looking forward to it. In fact, even if there is no bonus, he still hopes that the experiment will succeed, after all, he has contributed so much of his own blood.

Zhao Yi was also thinking, he didn't promise casually.

Resistance to HIV infection is a very important discovery, but most studies are inconclusive. However, he has used his own ability to determine that what plays the role is 'a certain infection-related antibody protein'.

If this protein can be found, it will be of great significance to the continued research on AIDS. It will definitely be taken seriously by the country and the world, and it is inevitable to receive a bonus.

In addition, it is the direct economic value.

This discovery itself has great economic value and can help develop anti-HIV drugs. Pharmaceutical-related manufacturers will definitely be interested, because it is not a project issued by the state. It may be possible to apply for relevant patents, and it can also be related to related patents in the future. When manufacturers cooperate to develop drugs, the money and benefits involved will be huge.