Genius of the Rules-Style System

Putting aside how attractive hairy crabs are for now, several researchers in the laboratory are still discussing the experimental direction of neural signal transmission.

It is very, very important to find the direction at the beginning of the experiment. Perhaps the initial choice can determine 'how far' you can go.

Zhao Yi said he supported Zhang Wei's idea, but he just felt that doing a large number of animal neurological experiments to collect data was a waste of money but of little significance, because he could find out from a single experiment. To find out the key, you don’t need to do too many similar experiments.

At the same time, they also agreed on another direction, which was Li Ming's suggestion, to study nerve cells.

Nerve cells have been studied countless times. It is indeed difficult to obtain results from ordinary experiments, but researchers at the Institute of Biomedical Research are very good at research on cellular mechanisms.

This is their specialty.

When doing a difficult research, it is not a good decision to throw away your expertise.

Even if there are no results in the study of nerve cells, they can still get some data or some characteristics of nerve cells to compare with other experimental directions, which provides a certain reference value.

Conducting research in two directions at the same time is nothing for Zhao Yi Laboratory. They have enough researchers and sufficient financial support to conduct multi-directional research.

The research direction of nerve cells was left to Li Ming and Ai Lixin, while Zhu Qi and Zhang Wei were responsible for restoring classic experiments.

After the work was assigned, preparations began.

Leaving aside the study of nerve cells, the restoration of classic experiments on nerve signal transmission did not start with the hairy crabs. The first thing they did was the experiment conducted by British scientists Alan Hodgkin and Andrew Huxley sixty years ago. , which is to measure the changes in motor membrane potential due to signal conduction through nerves.

The purpose of the reduction experiment is to see the discovery of the two Nobel Prize winners, that is, when neuron excitement occurs, sodium ions flow from outside the cell membrane into the cell membrane, and then potassium ions flow from inside the cell membrane to outside the cell membrane, causing The membrane potential returns to normal.

This is where the classic Hodgkin-Huxley model comes from.

Later, he will conduct the 'hairy crab' experiment, tracing the research process of Kazaki Kazuki, studying the leg nerves of crabs, and using a microscope to observe a small piece of reflective platinum placed on it, and then irradiating the platinum piece with a laser beam.

By measuring the angle of reflection of the laser light, it is possible to detect whether the width of the nerve bundle changes slightly when an action potential passes through it.

This requires subtle operations and many experiments.

It is said that Kazuji Tasaki and his doctoral students conducted hundreds of measurements and made detailed records, and came to the conclusion that "when the action potential passes, the nerve bundle will slightly widen and then narrow", and the process of change occurs , which takes only a few milliseconds.

When Kazuji Tasaki was doing research, technology was not so advanced, and the experimental equipment he used was definitely incomparable to what it is now.

Nowadays, with the help of high-tech precision instruments, it is very easy to measure the accurate time of reaction.

The main purpose of this experiment is to prove that there is a direct relationship between nerve conduction and cell membranes.

The report given by Kazuji Tasaki is that when nerves undergo an excitatory reaction, the cell membrane will deform and the surface will rise by about seven nanometers.

The deformation of the cell membrane plays a role in nerve signal transmission, which can be explained to a large extent that nerve transmission relies not only on electrical signals, but also on mechanical waves. Only mechanical waves can cause tremors.

Of course.

Kazuji Tasaki did not receive much recognition because many people believed that deformation of cell membranes was a by-product of electrical signals.

But no matter what, the most important thing is that the problem has not been solved.

What Zhao Yi's laboratory is doing now is to restore the two experiments that discovered the electrical and mechanical signals transmitted by nerves. They need to measure and record detailed data in the experiments for analysis.

The above two experiments don't sound like biomedical research, but rather like physical experimental research. At first, everyone didn't pay attention to it. When the experiments actually started to be designed, they found that it was not that easy to restore. There were still problems with the equipment and measurement tools. It’s easy to solve, but it’s best to have a professional physicist help

Industry specializing in surgery.

It is definitely not that easy for biomedical researchers to conduct physical experiments and measure physical data.

So Zhao Yi decided to find a physics person to help. He didn't need a top international experimental physicist, even one who knew some physical experiments would be fine.

Then he found Gao Yihua.

Gao Yihua is Zhao Yi's physics teacher and is very familiar with Zhao Yi. However, Gao Yihua is mainly engaged in education and has no impressive results in physics research.

When he heard that Zhao Yi asked him to help with neurological experiments, Gao Yihua was a little confused, "Are you sure you didn't find the wrong person?"

"certainly."

Zhao Yidao said, "I'm just here to find you, Teacher Gao. Our laboratory is doing experiments to measure neural responses. We need people who know some physical experiments and some sophisticated measurement equipment."

The most important thing is the latter.

Zhu Qi and Zhang Wei have been engaged in biomedical research for a long time and have made detailed physical experimental measurements. The operation is not a big problem, but data errors may occur, and measuring data during the experiment is the most important thing.

And Zhao Yi...

It's better to let him study theoretical physics, but he doesn't understand experimental physics very well.

Gao Yihua is not a professional in scientific research, but at least he is a physics professor and often goes to the physics laboratory to do research, which will definitely be helpful to their experiments.

After hearing this, Gao Yihua nodded happily, "You already said you would help. I definitely agree. It's nothing."

Zhao Yidao said, "Help is help, but you still have to agree in advance. If there are relevant results, your name will also be on the paper."

"That's not necessary."

Gao Yihua didn't care at all.

Zhao Yidao said, "Just do whatever you want." He still takes good care of his friends.

Although Gao Yihua only helped in the past, if his help allowed the experiment to proceed smoothly and made new discoveries, it would definitely be recorded.

Zhao Yi brought Gao Yihua in to help Zhu Qi and Zhang Wei's team conduct experiments, and his mind became active. He felt that the team was still lacking people.

There are five researchers in the laboratory, plus Gao Yihua, the number is five and a half. Plus the associate researchers who can do research together, the number can exceed ten, and each of them is very capable.

But one problem with the team is that everyone is good at the same field, which is research on biomedical mechanisms.

Nerve signal transmission is not only medical research, but also involves professional neurology and physics. Physics has Gao Yihua and him, which is enough, but there are no neurological experts among them.

Neurology, which can be said to be medicine, is best to have someone who specializes in neurological research. Come and do research together. It will definitely be of great help in theory and experiment.

"Who are you looking for?"

Zhao Yi thought about it carefully and found that there were really no neurological experts in his social circle.

At this time, Qian Hong suddenly called and said that a doctor named "Deng Bingcheng" was visiting.

"Deng Bingcheng...doctor?"

Zhao Yi was a little confused for a moment and asked Qian Hong to bring Deng Bingcheng over.

It is not easy for people outside the school to find Zhao Yi directly. He is indeed in the school, but his whereabouts are kept confidential. When someone comes looking for him, he will be taken to Qian Hong.

Qian Hong will simply ask and contact Zhao Yi only if there are no problems.

In a small conference room in the Medical Science Center, Zhao Yi met the visiting Deng Bingcheng. Deng Bingcheng was nearly fifty years old, his figure looked a little lean, and he seemed to have a bit of a 'literary' atmosphere.

After he entered the conference room, he immediately shook hands politely and said with a wry smile, "Academician Zhao, it's not easy to meet you."

This is a sigh from the heart.

Deng Bingcheng didn't know Zhao Yi's contact information, so after he arrived at Yanhua University, he went directly to the Academic Affairs Office and asked about Zhao Yi. When he left the house, he was interrogated by two armed policemen with guns.

After an interrogation, he saw Qian Hong, and then Qian Hong asked again. After waiting for more than half an hour, he followed the armed guard to the Medical Science Center.

This feeling is no worse than meeting a big leader.

Zhao Yi said apologetically, "I can't help it. The bosses are always worried about my personal safety. Actually, I feel quite safe."

"This is right!"

Deng Bingcheng said, "You are the backbone of the country's science and technology. Nothing is more important than safety. If there is a problem with your safety, it will be a huge loss for our country."

"Thanks."

Zhao Yi responded politely and asked Deng Bingcheng to sit down.

Deng Bingcheng also jumped into the topic directly. Talking about the reason for the visit, "I applied for a brain nerve research project, and the result..." He smiled bitterly, "The approval was approved, and I gave him 100,000 yuan. To put it bluntly, I included the materials. There’s not even enough money.”

"Yeah." Zhao Yi listened.

"Academician Zhao, I saw that your laboratory has also applied for a neural research project, right? I was wondering if I could come over here and study with you..."

This request is somewhat abrupt.

Deng Bingcheng was a little embarrassed when he said it. The main thing he said was that he hoped to use the funds from Zhao Yi's laboratory to do his own research, but he really wanted to do some research on brain nerves, so he could only shamelessly come over and ask. .

Deng Bingcheng added, "I am not doing my own research alone, but working with you. The two studies have a lot in common, and nerve signal transmission is the key."

"I noticed that your team doesn't seem to have any professional neurology experts. Domestically speaking, I am still a little famous in the field of neurology, so maybe that can be helpful."

Zhao Yi dragged his chin and thought seriously, as if he was wondering whether he agreed. In fact, he was lamenting that Deng Bingcheng came at the right time, and he felt like he was 'talking about Cao Cao, and Cao Cao has arrived'.

Before, he thought about finding someone who had research on neurology, but he never thought about finding a top 'neurologist'.

Before meeting Deng Bingcheng, he had obtained Deng Bingcheng's information and knew that he was from the North Central Affiliated Laboratory. He was one of the top neuroscientists in the country and a famous neurosurgeon who had performed many successful surgeries.

Such top neurological experts are exactly what laboratory research needs.

Of course, you still have to be more reserved.

Zhao Yi thought carefully for a long time and said with some embarrassment, "Our laboratory has a lot of people. There are five researchers involved in this project, including myself."

Deng Bingcheng sounded a little disappointed.

"but……"

Zhao Yi's words took a turn, "Science has no borders, let alone, we are all going to do research on neural transmission, we can do it together."

Deng Bingcheng suddenly showed joy.

Zhao Yi paused for a moment, nodded and said, "It's okay to do research together. There are some things that need to be agreed in advance. First of all, we took over the project, and the results, especially those related to neural transmission, belong to our laboratory, and China The laboratory affiliated with Beijing Medical University has nothing to do with it, but you can add your name to the results paper."

Deng Bingcheng nodded seriously. He didn't care about this at all, because he felt that neural signal transmission is a very difficult basic research. Even if there are results, they are very small. There is no need to discuss the attribution of the results. In addition, the project originally belongs to Zhao Yi's experiment. Laboratory, it is reasonable for the results to belong entirely to Zhao Yi's laboratory.

Zhao Yi talked about the next point, "Although our research has many similarities, there are also many differences. You are doing brain nerve research, which should be more medical, right?"

"If the results are related to brain nerve research, they will still belong to our laboratory. If there are medical-related patents, we will account for 80% of them."

"It's up to you to decide on the paper. Whoever publishes the research will publish it."

"In addition, a confidentiality agreement must be signed."

After Zhao Yi finished speaking, he looked at Deng Bingcheng seriously. The demands he made sounded excessive, but in fact they were legitimate demands, because research funding comes from laboratories and research institutes, and research related to brain nerves may have more funding. Spending millions, even if the research is overlapping, will not save much money. They are equivalent to providing Deng Bingcheng with scientific research funds and environment.

If a scientific research institution cooperates with an enterprise, the terms signed are almost similar. The enterprise provides funds and occupies the ownership of technology patents, while the scientific research institution is responsible for research and only occupies a small part of the technology patent rights.

In addition, the reason why Zhao Yi asks so much is directly related to the process of producing results.

Although Deng Bingcheng is a top neuroscientist in the country, the possibility of achieving results in brain nerve research is still very small, but it is different when he assists and guides the research process.

He can use his ability to find out the key to the experimental process, results and data, which will definitely help the research a lot. It can even be said that he is the key to the results.

If it were Gao Yihua, he wouldn't ask for so much. The two of them are very familiar with each other. Gao Yihua is still a professor at Yanhua University.

Deng Bingcheng is different.

He is an outsider.

When doing research with outsiders, you must agree in advance that you should be a villain first and a gentleman second, so that there will be no conflicts or disagreements.

After listening to Zhao Yi's words, Deng Bingcheng frowned and thought carefully for a while, and finally nodded and said, "Academician Zhao, I agree with everything you said, but my research may incur additional costs..."

“Funding is not an issue!”

Zhao Yi waved his hand, "If you have any requests, just say it directly. It doesn't matter if it's too important. Whatever you can do is fine."

Deng Bingcheng suddenly brightened up.

"Funding is not a problem!" It sounds so heroic.

As a researcher who has long been worried about funding, Deng Bingcheng has an urge to cry.

Which scientific research institution can cooperate with his experiments and provide enough financial support, even if it means working for free.

…

Deng Bingcheng signed three agreements in a row, including a cooperative research agreement, a results distribution agreement, and a confidentiality agreement. He felt like he had signed a contract of sale, which even included working time regulations.

For example, you must work more than a thousand hours on related projects.

A thousand hours!

Because I have my own primary doctor job, I can work up to three days a week on average, eight hours a day, which takes almost a year.

Fortunately, there is a clause in the agreement that Zhao Yi Laboratory and the Biomedical Research Institute will provide an additional funding of no less than one million and a salary of more than 50 per hour.

"Fifty dollars an hour..."

"Although it's not much, just think of it as extra money." Deng Bingcheng could only smile bitterly. Compared with ordinary working people, fifty yuan an hour is not low, but he is the top neuroscientist and famous neuroscientist in the country. Surgeon, fifty an hour is not enough.

Of course.

While having funds to support research, he could also make extra money. Deng Bingcheng was very satisfied with the agreement.

He's also looking forward to getting to work.

At noon the next day, I finished my work in the hospital and came to the Medical Science Center to get familiar with the environment.

When they arrived at the door of Zhao Yi's laboratory, they saw a young man who seemed to be a student, holding a large plate of hairy crabs with an attractive aroma, and pushed the door open and placed it on the table outside.

He also shouted, "The chef of the restaurant made it. It's just out of the pot, so keep it hot!"

Deng Bingcheng looked at the plate and saw that among the dozen hairy crabs, one was a 'king crab'. He smelled the fragrance and swallowed, and asked the young man next to him, "Is this...?"

"Lunch!"

Fan Lei said cheerfully, and then took the initiative to shake hands with Deng Bingcheng, "My name is Fan Lei, the logistics staff of the institute. Are you Dr. Deng Bingcheng? If you work here in the future, you can come to me for any life matters."

"okay."

Deng Bingcheng nodded and continued to ask, "Is this lunch? Laboratory lunch?"

"Right? What's wrong?" Fan Lei asked in confusion.

"Oh, nothing, just asking."

Deng Bingcheng tried his best to suppress the shock in his heart, so that he would not show off his "old hat", but he was thinking in his heart, "If I had known that working meals would be this standard, I shouldn't have gone back yesterday. No wonder the Institute of Biomedical Sciences has become the first in the country , this is how to treat scientific researchers kindly!"

"I originally thought that Zhongbei's treatment was good, but it seems that my horizons have been limited."

"Those were poor days!"

"or……"

"Resign? Come here to look for opportunities? I am a neuroscientist and come to the Medical Science Center to do research. My major is the same, right?"