I can extract side effects

Wei Kang hurried into the office.

"Anmei, help me check all the information on Daxia Zhizao."

"Okay." A sweet female voice sounded through the Bluetooth headset: "Let me first introduce you to Daxia Zhizao, a company..."

"Daxia Zhizao is the leader in the research and development of upstream equipment for gene sequencing in China. According to public information, the compound growth rate of the company's revenue has exceeded 200% in the past three years, and it occupies about one-third of the domestic gene sequencer market. The global installed capacity exceeds 1,100 units. Covering 16 countries and regions, with more than 300 users."

"Gene sequencing technology has developed from the first-generation sequencing technology to the fourth-generation sequencing technology, but because the four-generation sequencing technology has its own advantages and disadvantages, and the application fields are also different, the first-generation sequencing technology has not been eliminated. The current sequencing market It is the coexistence of fourth-generation sequencing technologies, and the second-generation NGS sequencing technology is the main one on the whole."

"At present, Daxia Zhizao and Immana are competing in the second-generation NGS sequencing technology market. Although Daxia Zhizao is developing well, its profit margin cannot be compared with that of Immina. The reason is that its sequencing equipment is mainly Supply parent group Daxia Genomics and its related companies with sequencing services.”

"The two parties are actually two sides of Daxia Group's development. The former produces sequencing equipment, and the latter undertakes the former to provide sequencing services to the market. Without the support of Daxia Gene, Daxia Zhizao would not be able to make it to where it is today."

Wei Kang suddenly asked: "What is the biggest risk of this company at present? Is there any scandal? If I want to reach a long-term strategic cooperation, this is something I need to consider carefully."

"There are two main risks. One is the issue of listing. Daxia Zhizao has been applying for an IPO on the Science and Technology Innovation Board, but it has been delayed. The main reason is the related party transaction with Daxia Gene, which has been criticized by many securities practitioners and the media. Queries, and several listing applications have been suspended by the exchange on the grounds of missing materials.”

"If it is successfully listed, Daxia Zhizao will raise more than 2 billion yuan, which will greatly promote technology and sales. Otherwise, relying on Daxia Gene's support behind it will inevitably make people lack confidence in its future development."

"Secondly, the company is also deeply mired in litigation. In recent years, it has encountered a series of patent lawsuits by its competitor Illumina."

"Ilmina launched protracted patent lawsuits against Daxia Zhizao and its subsidiaries, distributors and customers overseas. The countries and regions involved in the lawsuits include Eagle Country, Europa and other 12 countries and regions. In these lawsuits, some Daxia Zhizao lost the lawsuit, related products were banned from sale, some lawsuits were dismissed, and some lawsuits are still pending.”

"When Daxia Zhizao will be able to get out of the quagmire of litigation is still unknown, but it is foreseeable that if these marathon patent lawsuits are not dealt with as soon as possible, the future will definitely bring greater risks to the company."

"In addition, the boss of Daxia Gene controls 53% of the shares of Daxia Zhizao, and the boss's reputation is a bit extreme. Daxia Gene's reputation is also very bad, and scandals continue to emerge. According to online data, the salary of Daxia Group is full. The lowest, causing employees to leave one after another, unable to retain real talents. These are risks that need to be considered.”

Wei Kang couldn't help being curious: "The salary is the lowest in the whole bank? How low is it?"

"Shenzhen headquarters, undergraduate 3000."

"This..." Wei Kang couldn't help being stunned: "Good guy, this is lower than a certain Fukang's sweatshop."

"The boss of Daxia Gene, Wang Qing, is 69 years old. He graduated from junior high school and started from scratch. He prefers to talk big and is good at capital operations. After Daxia Gene went public, the stock price rose from 20 yuan to 300 yuan, and now it has fallen back."

Anmei is constantly supplementing the collected information.

"Boss Wang reduced his holdings by more than 20% of the shares during the company's ups and downs, earning a lot of money, and very frivolously applied for the listing of the company's best asset, Daxia Zhizao, and his intentions are self-evident. "

"Overall, the comprehensive rating of Daxia Zhizao is B-, and the comprehensive rating of Daxia Gene is D."

Wei Kang shook his head: "The 70-year-old man at the helm must have a generation gap with me. It's not that I have a prejudice against him. It's mainly that the boss with a junior high school education is unreliable to start a high-tech enterprise."

"You are right. I have some of his deeds here, which may be a reference for your decision-making."

"Wang Qing claims that the ultimate goal of Daxia Gene is immortality. He once proposed that everyone can live to 100 years old, and he can live to 120 years old. He also insisted that he has achieved a significant reverse growth. After the photo was taken 70 years old is younger than 50 years old, and this miracle even became a trending search."

"He ran around appealing that saving money is worse than saving life, hiding Moutai for 50 years is worse than saving his own cells, and tried his best to persuade rich people all over the country to invest in the technical field of 'extending life', which is Daxia Group."

Wei Kang couldn't help saying: "Tsk tsk, Boss Wang is really a master of hype, I feel ashamed."

He rubbed his chin and said thoughtfully, "When you say it this way, I feel that this company is a bit too much for show, and I wonder if we want to cooperate with Daxia Zhizao for a long time."

"However, if you really want to use a domestic sequencer, there is no choice at present. Only Daxia Zhizao is successful."

"By the way, how do Daxia Zhizao's customers evaluate its products?"

"The advantage of the sequencer made by Daxia Zhizhi is that it can greatly save costs while ensuring the same DNA fragment read length and yield."

"Last year, the research team of Bangguo published a research article in the Journal of Genetics, analyzing and comparing the performance of sequencers made by Daxia Zhizao and Illumina at the level of whole gene sequencing."

"The researchers used a sequencer to sequence normal and tumor tissues from lung cancer patients in the United States, and compared the generated data in parallel. By evaluating the raw data of the two platforms, they found that in terms of quality control, both showed similar results. The quality and genome coverage of deep reads.”

"At the same time, the research team compared the whole genome sequence to the reference genome, and the results showed that the coverage rate of all samples was above 99.9%. The sequencing results of the two sequencers were very similar, and the overlap ratio was quite high, each sample was 92.0% and 93.0%."

"Through various data support, the research team believes that both platforms provide high-quality sequencing data and sufficient genome coverage, are suitable for whole genome sequencing analysis, and the sequencing performance is highly consistent, which shows that the two platforms The performance of the platform has reached the international leading level.”

"In addition, Ruiji Hospital and Peking University Cancer Hospital in China have used the sequencing platform made by Daxia Smart to sequence the genes of cancer patients and published articles in journals such as 'Cell'."

"There are dozens of other papers that have been researched and published using the Daxia Smart Sequencer."

"It can be seen that the sequencer made by Daxia Zhizhi has been successfully applied to research in many fields."

Wei Kang couldn't help but nodded, hesitantly said: "Although Daxia Zhizao and Daxia Gene are the same group and the same boss, they are still different after all. Why don't you buy a few and try it out? The machines are good. Just use it."

"Your decision is very wise. However, Anmei still wants to remind you that although the second-generation sequencing technology is currently the mainstream, the third-generation single-molecule sequencing technology and the fourth-generation nanopore sequencing technology are developing rapidly and have begun to be used in clinical and application in scientific research."

"Compared with the second-generation sequencers, the third-generation and fourth-generation sequencers have the advantages of high read length and low cost, which can reduce the cost of a whole genome sequencing to less than 100 US dollars. At the same time, the gene fragments that can be detected at one time are relatively long, and the sequencing speed is fast. The improvement is very fast, and the fourth-generation technology can compress the time to less than 4 hours, while the second-generation sequencing takes several days to complete."

"The only disadvantage is that the technology is not mature enough to achieve a satisfactory sequencing accuracy. The accuracy is about 86%, and it cannot be used independently. In most cases, it can only be used as a supplement to next-generation sequencing."

Wei Kang was a little surprised and said: "This is really good, we can also buy a batch of fourth-generation sequencers to supplement it. By the way, is there any company that can use fourth-generation sequencers?"

"The foreign Oxford Nanopore company has relatively mature technology in this area. The company has been listed, and has also mass-produced a high-profile handheld nanopore sequencer, which can be used in extreme environments such as space. Deciphering the Ebola virus sequence."

"In addition, scientists have completed real-time gene sequencing with only a mini handheld device and a portable computer in Antarctica, where there is no network or laboratory facilities."

Wei Kang shook his head: "This is also a foreign company, or it is the only one, so we can't have it. Are there any nanopore sequencer companies in China?"

"In China, only a company called Carbon-based has released the first nanopore gene sequencer. This product is about to be mass-produced and launched to the market."

Wei Kang couldn't help being a little disappointed: "Mass production is about to happen, but it hasn't yet, so let's wait."

He thought for a while, and then said: "In fact, the fourth-generation nanopore sequencer is very suitable for shared laboratories. You can buy a few and come back to try."

Later, he sent instructions to Zhao Xiaojie, asking the two companies to purchase several sequencers and send them to the R\u0026D department for trial use.

After Zhao Xiaojie received the order, he wiped the sweat from his forehead and started running non-stop again.

Qi Jun, the president of Carbon-based Company, was also very pleasantly surprised after receiving the inquiry call.

Holding his mobile phone, he began to introduce his products in a continuous manner.

"Mr. Zhao, thank you very much for your call. We have invested 200 million yuan to establish a production base in Shu City at the end of last year, and plan to put into production a series of products such as nanopore gene sequencers and kits. The annual output can reach 2,000 units, supporting detection reagents 1 million servings."

"Welcome to Shu City for an investigation. In the past year, we have cooperated closely with local institutions such as Sichuan University and Shuxi Hospital in the fields of infection diagnosis, forensic identification, and tumor research."

"You can see these cooperation cases in our company. At present, the best feedback from our customers is the field of forensic medicine."

"DNA testing is widely used by forensic labs around the world to solve criminal cases, and our portable nanopore sequencer is well suited for crime scene analysis with 99.8% accuracy, and has recently been gaining ground in this area."

"In scientific research, the nanopore tester is mainly used for sequencing viruses or bacteria because their genomes are much smaller than humans, but it also has great potential for large-scale whole-genome sequencing in humans."

"In this regard, we also have scientific research cooperation with many hospitals, and the feedback from our customers is very positive and positive."

"Don't worry, our first mass-produced machine will be launched next week, and we will send it to Sanqing for trial as soon as possible."

The two sides successfully negotiated the first batch of orders.

Hand-held sequencers are very cheap. Foreign products only cost US$1,000 a unit, while domestic prices are less than 5,000 yuan. Therefore, Zhao Xiaojie ordered ten units at one go. After the contract is signed, they can be officially shipped.

Zhao Xiaojie put down his dead phone and rubbed the center of his brows, feeling parched and exhausted.

He made phone calls all day and kept communicating with the bosses of the two companies, and finally finalized the two orders within one day.

Just wait for Monday to fly over to inspect the factory before signing the contract.

There are two companies, one is in Shu City and the other is in Shenzhen City. He probably will be exhausted from running one of them in a day.

But there is no way, who told him that he didn't make a good risk control and preparation plan, and almost screwed up the matter.

Damn Immenar, damn Eaglelander, is simply vile and vile.

I hope that these two domestic detectors will be able to stand up to Mr. Wei's satisfaction.

Thinking silently in his heart, he poured a cup of strong tea, turned on the computer again, and prepared to continue his struggle.

There is also a list of fully localized equipment to be finalized this week.

*****

At a quarter past eight, Huang Qin hurried into the genetic laboratory on the 11th floor of the Pangu Building.

After successively developing several genetic medicines, Biological Laboratory has set up a special genetic laboratory, which mainly develops single-gene disease medicines.

As the name suggests, Huang Qin is very diligent and studious, and has been working with such an all-around doctorate expert like Williams, so he has made rapid progress and has been promoted to become a research and development team leader.

His good friend Williams was also promoted and became the deputy team leader, and he was still in the same team.

The two worked happily together, which can be called a golden combination, and they are well-known in the entire biological laboratory.

After all, two people with diametrically opposite appearances, one tall and one short, one strong and the other thin, staying together all day, entering and exiting together, is still quite eye-catching.

But what surprised him was that a powerful figure like Williams was only promoted to deputy team leader, and he was still his assistant, and the leader was too ignorant.

He was a little ashamed, because the other party made more contributions in daily work, and his education was higher than his.

It may be racial discrimination. After all, Sanqing is a Chinese company and likes to train its own people. Foreigners are not promoted as fast as they are, and Williams is still a postdoctoral fellow with a bright future. Maybe he will leave after a few years. stay.

He could only comfort himself like this.

As soon as he sat down in the office, he heard Williams calling himself.

"Qin, come here quickly. The laboratory has newly installed a few gene sequencers produced by Huaxia. Let's try it. Let's see what is the difference with Immena's sequencing platform."

Williams speaks Chinese fluently, without any foreign accent, but when he pronounced the sound 'Qin', there were still slight changes in pitch, which sounded more like a familiar appellation 'Qi'.

This title made Huang Qin a little dumbfounded. Since Williams called him that, all the colleagues in the laboratory began to call him 'dear' enthusiastically like a cat scouting Xiaoer.

The problem is, it's weird to say this name from a bearded 1.8-meter man like Williams. It seems that something is wrong. It looks a little flirtatious, and even the new beauty colleague listens to it. After that, the look in his eyes was a little strange.

Huang Qin responded, put on a white coat, and followed Williams into the laboratory.