I can extract side effects

Sanqing Headquarters, President's Office.

Gu Xian sat across from him, holding a lab report in his hand, reporting the clinical results of oral insulin.

"After clinical phase I and II trials, the efficacy of oral insulin has been proven."

"Compared with injecting insulin, it is more convenient and easy to use, and it has been warmly welcomed by patients."

"Especially some young children have weak self-control and it is difficult to manage sugar control. Oral insulin has greatly improved their treatment experience and strengthened the stable control of the disease."

"The trial is progressing very quickly. I believe that if this continues, the scale will be expanded and the third phase of clinical trials will be carried out in a few days."

Wei Kang listened to this series of data, and said thoughtfully: "So from another perspective, the difficulty for patients to control their disease mainly lies in the treatment experience. If it is convenient and simple, then the compliance will be greatly enhanced. "

Gu Xian nodded: "That's right, especially for chronic diseases like diabetes, it takes decades of precise control of the body and extreme self-discipline to keep the condition from getting worse."

"It's okay if it's type I diabetes. After all, it's genetically related. Type II diabetes is mainly caused by indulgence in diet. If they are self-disciplined, they won't get this disease."

"In addition, diet weighing, insulin dosage calculation, blood sugar measurement, and daily records are all very troublesome and professional things for patients. Many people can't stick to it, especially children. Parental supervision is needed, if you meet irresponsible or not understanding parents, then..."

Gu Xian spread his hands and said nothing, but the meaning he wanted to express was self-evident.

Wei Kang pondered and said: "Then if we can handle this difficulty, can we help them control sugar?"

Gu Xian agreed: "That's natural. If nothing else, just record the daily carbohydrate intake and then calculate the insulin dosage based on the blood sugar results. .”

"Insulin doses are generally calculated based on blood sugar and carbohydrates. Due to the different insulin sensitivities of individuals, about every 12-15 grams of carbohydrates requires 1 unit of insulin. Because of low insulin sensitivity, people with large body weight need The amount is greater."

"Calculated by body weight, if the blood sugar is high and the condition is severe, it should be 0.5-0.8μ/kg; if the condition is mild, it should be 0.4-0.5μ/kg; if the condition is severe and under stress, it should not exceed 1.0μ/kg."

"Daily insulin dosage (μ) = [fasting blood sugar (mg/dl) - 100] × 10 × body weight (kg) × 0.6 ÷ 1000 ÷ 2 (100 is the normal value of blood sugar); × 10 converted per liter of body fluid is higher than normal Blood sugar volume; ×0.6 is 60% of body fluid volume; ÷1000 is converting blood sugar mg into grams; ÷2 is 2 grams of blood sugar using 1 μ insulin. In order to avoid hypoglycemia, actually use 1/2-1/3 of the amount .”

"Of course, this is just a simple formula. Everyone has different physical conditions, different eating habits, and different insulin dosages. It is specific to the individual and should be calculated comprehensively according to his own situation."

Wei Kang was a little speechless: "This formula is too troublesome. If you replace it with someone who is not good at mathematics, I'm afraid you will feel dizzy after reading it."

"So, the problem of wrongly injecting insulin is very common among people with diabetes."

Gu Xian spread his hands and said helplessly: "It is really troublesome for diabetics to control sugar. No wonder many people can't persist. Of course, this also raises the threshold in disguise and improves the loyalty of patients."

"Most patients are reluctant to change their medication after their medication is stable. Moreover, insulin from different manufacturers has different purity, onset time, and drug effects are slightly different. It is difficult for patients to change medication after they get used to it."

"Domestic manufacturers also have good sales, but they are still unable to shake the status of the three giants. There may be no reason for this."

Wei Kang thought for a moment, then said: "Because oral insulin is convenient to take, it may be more likely to cause patients to mistake the dosage."

"As a manufacturer, we should pay attention to this aspect and try our best to provide patients with a convenient and easy-to-use guidance to prevent them from making mistakes."

Gu Xian nodded and said, "That's right. At that time, I will also arrange medical representatives to train doctors so that patients can get professional guidance from doctors."

"It's far from enough." Wei Kang frowned and said in thought, "Now it's an information society, and we can provide detailed guidance on the mobile app."

"The Longtu software is quite popular now. We want to add more functions to diabetic patients, especially those who use oral insulin, and provide an integrated diabetes treatment plan in the form of an app."

Gu Xian showed joy, and praised: "This plan is really good, better than I imagined."

"Let me think about it, this integrated treatment plan should have at least two functions, individualized real-time counseling for patients, and clinical decision support."

"The former allows patients to conveniently collect and store information such as diet, blood sugar levels, and drug treatment options. For example, through manual or voice input, connect the device to a blood glucose monitor to obtain relevant data, and patients can also obtain personalized information through the app. feedback and reminders.”

"In the latter case, the app can analyze data such as existing drug doses, blood sugar fluctuations, and carbohydrate intake per meal, and provide preliminary diagnostic recommendations. Doctors can also adjust patients' medication plans based on these data. "

Wei Kang added: "If this part of the function can be provided to diabetic patients for free, I believe it will promote the popularization of oral insulin and make it easier for patients to switch from injecting insulin to our side."

"It is best to upgrade the app during the third phase of the clinical trial, so that patients can experience the power of these functions when they are testing the drug. When they can choose independently, they can no longer do without the functions on the app. .”

Wei Kang decided this matter in a few words.

"You write a report as soon as possible, describing the functions to be provided in detail, and I will ask Gao Fei to contact you to complete the app upgrade together."

After Gu Xian left, he called Xiang Gaofei, who was in charge of Longtu App's business, over again.

The software business that Xiang Gaofei is responsible for has been quite tepid in recent years, and all he does is support work for medical devices.

Over time, he also came up with some new ideas.

So after listening to Wei Kang's description, Xiang Gaofei said straight to the point.

"Mr. Wei, it is indeed a good business to add the disease management function of diabetes to the Longtu app. I will fully support and complete this upgrade as soon as possible."

"However, besides that, I have a new business idea that I want to report to you."

Wei Kang laughed: "Okay, Lao Xiang, I didn't expect you to come prepared. Tell me, I'm all ears."

Xiang Gaofei weighed his words and said: "In the past two years, AI has been very popular, not only AI painting, AI writing, but also AI consulting, AI search, etc. So I have been thinking, can we also take advantage of AI? With this trend, let’s develop AI diagnosis business?”

Wei Kang's eyes lit up immediately, and he agreed: "Good idea, Lao Xiang, since you said that, you must have thought about it, let's discuss it together."

Xiang Gaofei smiled shyly, and continued: "In the past, in terms of AI diagnosis, one is that the business is not mature enough, and it will be difficult for everyone to accept artificial intelligence to see a doctor for a while."

"But now AI is increasingly entering people's lives, and the social acceptance has been greatly improved."

"Honestly speaking, my son is using AI to do his homework now, and neither the teacher nor I noticed it until the grades dropped during the exam, and it was revealed."

"If you think about it, elementary school students can accept AI now, and adults are even more able to accept it."

"Two, in terms of big data and analysis algorithms, our technology was not advanced enough to settle down, but now that the medical device business has started, various medical data in the background are no longer lacking. AI training will no longer be difficult."

"Thanks to the popularization of electronic watches, our monitoring module is now basically a piece of everyone's hand. People have become accustomed to using the Longtu app to provide health diagnosis."

"So I think this is also a great opportunity. It is entirely possible to launch the diabetes management function first, create a professional disease steward role, and then launch AI diagnosis on this basis."

"As long as there are patient cases and body test data, in fact AI can already provide preliminary diagnosis of some basic diseases on the basis of big data training."

Wei Kang showed appreciation in his eyes, and said: "Your idea is very good, it just coincides with mine."

"I have always been optimistic about AI diagnosis. Indeed, as you said, it was difficult for people to accept AI to treat themselves in the past. You must know that some patients can't even trust doctors. How can they trust AI?"

"But now AI painting, AI writing has let everyone see the power of AI."

"I believe that the time for AI to see a doctor is not far away. We must firmly grasp this trend."

"Just let go and do it, no matter if you want money or people, I will give you all my support."

Xiang Gaofei was overjoyed and said, "Thank you Mr. Wei, I will write you a detailed project report as soon as I get back."

*****

With the progress of the Phase II clinical trial, the news of the introduction of oral insulin has spread like a virus among the type 1 diabetics.

Almost everyone who heard it couldn't believe it at first, but when it was confirmed to be true, they were immediately ecstatic.

All of them got diabetes when they were young and had to inject insulin for life. Some of them have been doing this for more than ten years, and some have just been diagnosed.

But everyone is ravaged by the disease, and the urgency to get treatment is the same.

They need to measure blood sugar at least 5-6 times a day and inject 2-3 injections of insulin.

Every time I get an injection, I have to sneak around, avoid others, either hide in the toilet, or find a place where no one is there.

If they are seen, they will receive strange looks, and some may even lose their jobs.

They always have a candy bar or a biscuit in their pocket.

The meat, eggs and carbohydrates of each meal are accurate to the gram. When the food is difficult to digest, the carbohydrates are not counted correctly, forgetting to add meals, and exercising too much, the blood sugar curve will always jump up and down.

Blood-sugar needles leave pinholes on their fingers, and the skin at the site of long-term insulin injections becomes dry. Many people have red spots and bruises on their stomachs.

Some of them have a sensor the size of a mosquito repellent patch on their arm, and the probe of the sensor penetrates 5 mm into the skin to monitor blood sugar in real time.

From the moment they were diagnosed, their lives were firmly controlled by the thin blood sugar curve.

They must do their best to control blood sugar in a safe zone.

Only then will their lives go on. Otherwise, they suffer from hypoglycemia and face complications.

For them, their bodies are like a car with automatic transmission, which suddenly becomes a manual transmission, and the fuel tank often leaks oil.

Right now, there is a new opportunity to at least get rid of insulin injections and become able to take medicine like a normal patient, and everyone is unwilling to let it go.

They all want to participate in clinical trials immediately, try this new oral insulin, and see if it can replace daily insulin injections, and at the same time provide more data for the launch of new drugs.

Many people came directly from out of town to the First People's Hospital of Kunming to visit the outpatient clinic of the Department of Endocrinology and ask if they could sign up for drug testing.

Under such circumstances, the number of applicants for the second phase of the trial skyrocketed instantly, and it was soon full.

Since the number of patients with type 1 diabetes is relatively small, accounting for only 5% of all diabetic patients, there were not enough volunteers to test the drug before, so we had to find some more serious type 2 diabetic patients to supplement.

Now that the number of people is enough, the progress of the experiment suddenly becomes rapid.

For all the patients who participated in the trial, the treatment results were no different from those of insulin injections, or even better.

Just take the appropriate dose of pills before meals as usual, and you won't need any more shots.

As long as it is taken before meals on time every day, it can maintain stable blood sugar throughout the day.

The cases of hundreds of people are enough to prove that this oral medication can completely replace insulin injections and save patients from the pain and inconvenience of daily injections.

In this way, the Phase II clinical trial came to an end soon.

*****

At the same time, Xiang Gaofei gathered the strength of the whole department, and within half a month, he developed the diabetes management function.

Although it is the first internal beta version, it only has some basic functions without too many bells and whistles.

However, it was launched together with the Phase III clinical trial, and was pushed in a targeted manner in the background.

On this day, as long as diabetics who have registered with Longtu and uploaded their own medical records will receive a push message on their mobile phones.

"Longtu app has officially launched the diabetes management function. This function is an internal beta version, and it is only available to diabetics for the time being. Please update it according to the instructions."

"At the same time, the new oral insulin drug developed by Sanqing Group has entered the third phase of clinical trials. Interested patients are invited to apply in the background. The number of places is limited and first come first served."

Seeing this news, all diabetics were shocked.