I can extract side effects

Early in the morning, Wang Dali drove to the Kunming Animal Experiment Center.

This is a long-term cooperative unit of Sanqing, and general clinical animal experiments are carried out here.

Wang Dali skillfully put on the surgical gown, opened the door of the operating room, and saw an awe-inspiring scene.

I saw a pig under general anesthesia lying peacefully on the operating table, ready to dedicate itself to science, and waiting for the start of the "heart-changing" experiment.

Around the operating table, instruments and equipment of various shapes are humming and running, and the fluctuation curve is displayed on the screen, making a beeping sound, and the doctors are busy in an orderly manner.

Dean Liu Daming walked over with a smile: "President Wang, good morning, you came just as we were getting ready."

Wang Dali nodded to indicate that he was also a little nervous. Although the artificial heart was tested perfectly in all aspects in the laboratory, whether it can be used or not will not be known until it is on the operating table.

Dean Liu led him to the operating table, and introduced him eloquently.

"You see, although we are an animal experiment center here, we hire serious doctors with rich medical experience, and the instruments used are basically similar to the surgical equipment and instruments commonly used in hospitals."

"You Sanqing are really amazing. After working together for so many years, this artificial heart still shocked me."

"Tsk tsk, this should be the smallest artificial heart in the world. It's only 90 grams, but it's so powerful. It can even be charged wirelessly. In the future, patients don't have to carry a heavy battery pack around, which saves a lot of trouble. ..."

Dean Liu was full of praise for Sanqing's artificial heart, and Wang Dali nodded absent-mindedly "hmm" while listening. At this moment, all his attention was focused on the upcoming operation.

Under the two shadowless lamps, the medical staff were busy doing their duties.

Several doctors were gently poking the pig while discussing in low voices. They were performing endotracheal intubation on the sleeping pig in preparation for being connected to a ventilator for assisted breathing during the operation.

On the other side, the nurses were also busy, with surgical forceps, surgical scissors, scalpels, gauze, surgical threads... After a while, surgical instruments were all over the table of the operating cart.

"Because the pig's neck is very short, it is difficult to find the trachea, so it takes some trouble." Director Liu explained in a timely manner after some commercial praise.

Wang Dali nodded, and saw that the pig was ready and was turned on its side.

"The operation has begun." After Dean Liu said this, his face became serious, and he stopped talking, and he and Wang Dali watched the operation quietly.

The operating trolley was pushed to the right side of the operating table, and the equipment nurse stood aside, sticking to her post.

The two surgeons, one on the left and one on the right, stood on both sides of the operating table.

Pick up the electric knife, raise the knife and drop it.

Smoke rose and the pig's chest cavity opened.

A living heart beats on the screen.

Suddenly, the two doctors stopped at the same time and looked up at the screen.

"Why is blood pressure so low?"

"Give me a lidocaine."

"Give the salt water."

"Okay, okay, it's normal."

After a while of panic, the operation continued.

"Now we can give some heparin."

"Put on the defibrillator."

"Adrenaline, push!"

"70."

With various orders issued, the operation proceeded in an orderly manner.

The sounds of "Goo———" and "Woo——" kept echoing in the operating room, which was the sound of an instrument alarm.

The two doctors raised their heads from time to time to look at the screen, and then lowered their heads to continue the operation.

Wang Dali stared at the operation screen closely, without blinking his eyes, and dared not speak out loud.

On the screen, the doctor sewed a small round ring on the tip of the pig's heart, and then punched the hole punch down the ring.

Another doctor had already held the artificial heart in his hand. The moment he pulled out the air bag with his left hand, he inserted the inlet end of the pump into the opening of the apex of the heart with his right hand.

At this moment, the heart on the screen is still beating vigorously.

This is followed by anastomosis of the artificial blood vessel on the blood pump, which connects the pump to the left ventricle and the aorta.

Due to the first animal experiment, the operation was relatively conservative, only part of the apex was removed, and then the artificial heart was used as a ventricular assist device to replace the left ventricle.

It is equivalent to only taking half of the heart function, and the right ventricle does not have any action.

Unknowingly, a morning passed, and the time came to one o'clock in the afternoon.

Suddenly, the two doctors exhaled in unison and issued a password.

"Start the blood pump unit."

"Okay." Following the password, the artificial heart began to work.

"Remove the auxiliary breathing apparatus."

"Get ready to close your chest."

The operation was successfully completed, and the two doctors left the operating table.

They looked tired and were about to go to the operating room when they suddenly saw Wang Dali, their eyes lit up and they walked over quickly.

"Mr. Wang, the artificial heart really opened my eyes. I didn't expect to be able to perform an artificial heart transplant with my own hands."

"Mr. Wang, I heard that this is a project that you are fully responsible for. I have a few questions to ask."

The two looked happy, and you said each sentence.

Wang Dali nodded: "If you have any questions, let's talk."

"When will it be clinically applied and industrialized? I have a relative whose heart is not very good, and has developed into heart failure in the past two years. But he is too old to do a heart transplant, and he has been consulting with me about the treatment plan. I didn't have any problems before. The way, now that you see the artificial heart, there is hope in an instant."

The older doctor said excitedly.

Wang Dali pondered and said: "As you can see, it is still doing animal experiments, and there is still a long way to go before it goes on the market, but the registration work has been completed, and it is working towards clinical application."

"Such as the material of the pump, the edge of the collar, the thread, and various accessories, we have prepared and considered all these. At the same time, we have long-term cooperative suppliers for the parts of each part. Once the clinical trial is approved , the product can be launched quickly and benefit most heart disease patients.”

"However, even if it is the fastest, I estimate that it will take two to three years. After all, an important assessment index for artificial hearts is the survival time after transplantation. This time must be longer than ordinary drug clinical trials."

"If your relative really can't wait, he can apply for humanitarian exemption surgery, so that he can use the artificial heart in the research and development stage in advance. Of course, this is the last helpless choice. I still hope that he can recover as soon as possible."

The doctor's eyes became a little dim, he nodded and stopped talking.

Another younger doctor couldn't wait to ask: "Mr. Wang, my question is relatively simple. I would like to ask if you have any requirements for experimental animals? You see, this animal experiment uses pigs, so next time you can do it." Can't it be replaced by sheep?"

"Because the pig's aorta is very short, it is not easy to anastomose the blood vessels on the artificial heart to the aorta. It is a test for the doctor's skills. The sheep's neck is relatively long and the chest cavity is shallow, so the operation is not so difficult."

Dean Liu also explained: "This pump needs to pump blood from the left ventricle to the aorta, but the pig's chest cavity is very deep, the location is not well exposed, and the suture operation is difficult."

"Also, don't look at the heart beating very powerfully. It's actually like tofu. If you want to sew a needle on the apex of the heart, it's like threading the tofu. If you're not careful, the meat will rot."

"If it is an animal with a shallow chest cavity like a sheep, the heart is exposed better and the difficulty is less, so the stitches can be denser to ensure that the joint between the artificial heart and the myocardium is foolproof."

Wang Dali couldn't help laughing when he heard this, and immediately agreed.

"Of course this is possible. We have no requirements for experimental animals, as long as they are large animals, such as sheep or cows. In terms of surgery, we only look at the effect, and don't care about anything else."

The young doctor was very happy to hear that, and asked again: "Mr. Wang, I think this test was implanted on the apex of the heart, and only part of the ventricle was removed. So is it a ventricular assist device?"

Wang Dali said with a serious expression: "No, it is actually a total artificial heart. In addition to the ventricular assist function, it can also completely replace the left and right ventricles and realize all the functions of the heart."

"The next experiment, we will do it on sheep. This time, we will cut off the left and right ventricle, completely replace the original heart of the sheep, and then see how long the sheep can survive with this artificial heart."

The two doctors looked shocked, and at the same time their eyes widened in amazement.

"The total artificial heart can completely replace all the functions of the heart, and it can also be charged wirelessly. If it can survive in the human body for a long time, it will be the final form of the artificial heart."

Even Dean Liu muttered to himself.

"Imagine, a 90-gram artificial heart is installed in the body, as long as you put a power bank in your pocket, you can charge it and do whatever you want freely."

"What a wonderful thing this is for patients with severe heart failure."

The doctor who was consulting for his relatives suddenly grabbed Wang Dali's hand and asked in a trembling voice, "Mr. Wang, how long will this artificial heart last? Half a year? Or a year or two?"

He has made up his mind to wait until the day when his relatives can no longer support him, and apply for a humanitarian exempt operation for him, even if it only lasts for a year or two, it will be a life earned.

In his mind, Sanqing is the embodiment of high technology, so he has tried his best to prolong his life.

Wang Dali smiled slightly, and said calmly.

"The theoretical use time is about fifteen years. Of course, there must be discrepancies in practical applications."

"How long it can be used depends on the patient's own situation, but I estimate that it will be no problem to use it for ten years. If it is well maintained, it may be used until the end of the product's lifespan."

As soon as these words came out, the three of them gasped at the same time.

"fifteen years?"

Dean Liu let out a breath with difficulty, his brain was already buzzing with shock.

Fifteen years, this has exceeded the record for the longest use of an artificial heart, and it has also exceeded the imagination of the three.

If it can be done, it will definitely set off a storm in the field of artificial organs.

I just don't know what it will be like in human clinical trials.

The three of them looked at the sleeping pig on the operating table at the same time, their gazes were fiery.

At five o'clock in the afternoon, the pig woke up on the operating table and was successfully extubated.

One hour later, another 1000ml of urine was successfully urinated, and the vital signs were stable.

Wang Dali went home and had dinner, then rushed back again.

Under the watchful eyes of everyone, the pig stood up tremblingly on the operating table and let out a "humming" cry.

Clap clap!

Thunderous applause sounded instantly.

Wang Dali breathed a sigh of relief, a smile bloomed on his face, and he clapped his hands vigorously.

He was so hard that his palms were so painful that he couldn't feel anything.

When the applause finally stopped, his entire palm was already blushing.