I Spent Those Years In the Operating Room Fighting Monsters

"The optimal treatment process based on the current patient database?" Huang Jing didn't quite understand.

Lu Cheng is now in charge of basic research, but just now, Lu Cheng's description was clearly about clinical aspects.

Lu Cheng has basically never been to the clinic, so how could he bring up such a thing? Could it be that Lu Cheng secretly went to the clinic?

It's not that it was a mistake for Lu Cheng to go to the clinic. His job is to be a doctor, and it's his job to treat and save people, but now he can do more things and treat more people. As a doctor, it is not necessary to rely on the treatment of the disease in order to be able to cure the disease.

If Lu Cheng can research anti-VI drugs as soon as possible, then it will be called the real merits.

"Yes, Director Huang, as you know, Fang Nixin is a new member of our research group, and there is also Dong Zhen, who is quite talented in mathematics and computer fields, and is now my graduate student."

"So after I obtained the data of the patient database, I used the crawler software to crawl all the patient data, and then analyzed the results."

"This idea was thought of by Fang Nixin of our research group when he was ill." Lu became to avoid some unnecessary misunderstandings, so he gave the credit to Fang Nixin and Dong Zhen!

Now he, more honors and less similar honors, is really nothing.

As long as Lu Cheng's plan can be taken seriously as soon as possible, that's the right thing to do.

"Okay, I see. I'll give this plan to the expert team for review tomorrow."

Huang Jing agreed, and then said, "But Lu Cheng, now everyone's hope for you is basic scientific research, and you know that your focus is there."

"And there are many reasons why there is no unified clinical treatment plan so far."

"Because each professor has his own understanding of specific diseases and symptoms, there will be certain differences in the treatment plan. It is difficult to implement standardization."

"Besides, as far as your current data is concerned, it is only statistically significant and may not cause too much attention."

After listening to it, Lu Cheng pondered for a moment and said, "It doesn't matter, Director Huang, I called mainly because I felt it necessary to tell you that I did this, not to ask you to promote this plan or anything."

"But Director Huang, it doesn't matter if other experts or professors don't trust this plan, but I hope that they can be made public as a reference. Do you think it's okay?"

Believe it or not, that's someone else's business.

real.

If an internal medicine doctor came to say that he had created a new orthopaedic surgery that needs to be promoted, Lu Cheng's first reaction would be disbelief.

Scientific research and clinical practice are two quite different directions. Of course, graduate students of orthopedics can do experiments and research in respiratory medicine. As long as they master the basic skills and have some unique understanding ability, they can do it completely.

But an orthopedic doctor wants to interfere with the diagnosis and treatment plan of other people's respiratory medicine, which does sound a bit nonsense.

However, Lu Cheng didn't want to convince Huang Jing, he just wanted to take it out as soon as possible. Someone who believes in nature is the best. Even if he doesn't believe it now, with the accumulation of time, there will definitely be a subconscious left behind, and then he slowly leans up.

Lu Cheng couldn't guarantee that the solution he gave was really the most optimal. He just passed tens of thousands of simulations and finally got such an optimal solution. And in reality, in the process of statistics, it is also very close to this scheme.

Therefore, even if this solution is not the optimal solution, it is definitely one of the excellent solutions that can be thought of so far.

The significance and charm of statistics lies in obtaining general laws through sample simulation.

The more simulations you run, the closer you get to the truth. This is called sample to universal.

"okay!"

"Xiao Lu, you've been bothered. Rest early, it's not too early now."

"While you are working, you must also pay attention to your body. Now you are in charge of the general direction of the entire experimental process, you can't fall down."

"By the way, when you review the progress of the existing research group's experiments, you must strictly follow the principles. Once someone violates the rules, or there are ethical problems, you must stop the research as soon as possible!"

"Our country absolutely does not allow the behavior of scientific research lunatics." Huang Jing ordered seriously.

At this special time point, Huang Jing is really afraid that some research groups will go to the side and do some research across the time line.

For example, taking the medicine directly, skipping the animal experiment and doing it directly on the human body, get the results as quickly as possible.

Get famous early, get famous early, correct early mistakes.

This kind of thing happened just a few days ago. In order to speed up their pace, some research groups seem to have inoculated some vaccines on living bodies on a small scale.

It was reported by someone who knew the rules in the hospital, and now the two leaders of the entire research group are under control.

The ignorant and enthusiastic people who are willing to contribute to the anti-VI campaign got in touch right away, and are constantly observing its side effects 24 hours a day!

This is a big taboo.

There is no experimental protocol, which can be directly applied to humans without animal experiments.

This is true both domestically and abroad.

This is also a very important value of the Ethics Society today. Every subject must be recognized, and the certification report of the Ethics Society is the top priority.

If there is an ethical problem in the project, the Ethics Society will be jointly and severally responsible.

If there is no certification report, all research progress and results will be invalid.

This is a **** lesson bought with life in the early stages of the development of medical experiments in the long river of history.

…

Lu Cheng nodded and said, "Director Huang, I am watching the progress report every day, and the deputy team leaders will also review it repeatedly."

"It's just Director Huang, I thought of a problem, that is, if some research groups are lying about their progress, then I can't monitor their experimental procedures, whether they comply with the regulations, and whether there are any illegal behaviors."

"So I suggest that in research units that are currently conducting similar topics, a strict monitoring team should also be set up, and people from the ethics society and scientific research department of the unit are responsible for monitoring. Do not interfere with the progress and steps of the experiment, only monitor Whether the experiment is in line with the process.”

"It's very necessary."

Lu Cheng heard Lin Hui mention this, he must pay attention to the experimental process! Pay attention to the supervision, and I also heard Lin Hui say such things.

"Okay! In this regard, you are a knowledgeable person. I will listen to you. I will issue a document in the name of the office and let all units coordinate and deploy." Huang Jing also felt that supervision cannot be a matter of one person, nor can it be done by one person. Just a one-sided thing.

However, in order to speed up the progress of the experiment, it is absolutely impossible to advance the process of the experiment in a illegal and out-of-the-moment manner.

…

The next day, Lu Cheng came to the laboratory early, wandered around the laboratory of Dong Zhen and others, and then reviewed the progress of the experiments in their respective groups, and then started busy work, began to read emails, read A variety of materials, and then give answers to some of the questions raised by the research group.

In addition, academic exchanges should be conducted with people in other sub-direction research groups of VI research topics and exchange of opinions.

In addition, what Lu Cheng has to do is video conference, video conference, or video conference.

About one o'clock in the afternoon.

Fang Nixin called and told Lu Cheng good news: "Lu Cheng, I persuaded the chief director of the intensive care and respiratory department of our hospital, and they agreed with our treatment concept based on the data analysis we provided. "

"This morning, two teachers invited me to a video conference. I analyzed the theoretical reference of this plan and the ideas we analyzed in detail."

"They felt they could do therapeutic trials in small, batches."

"Because the corresponding drugs already have sufficient clinical data to support them, the program has only been slightly adjusted to be more standardized. Therefore, other additional procedures can be avoided."

"It is estimated that from this afternoon, such treatment will be able to start. And they also gave advice to do RCT randomization."

"In addition to the experimental group and the control group, the experimental group and the control group are divided into subgroups of patients with different degrees. In addition to the intragroup analysis, a subgroup analysis can also be done."

"At the same time, we can also make a comprehensive comparison between the patients in the experimental group and the patients in all databases across the country!"

"I'm looking forward to the promotion of this plan."

Fang Nixin is a person who understands research, so she speaks very professionally.

Traditional randomized controlled trials, or RCTs, are different from retrospective controlled studies RCS! It is to adopt a double-blind method to minimize unnecessary errors.

The establishment of subgroup analysis in the experimental group and the control group is more scientific, the workload is larger, and the data analysis requires a more rigorous attitude.

The professors of the respiratory department were also very patient.

Of course, Lu Cheng knew that the Department of Respiratory Medicine of the Second Xiangya Hospital was really capable of hard power. It was definitely in the top seven in the country. The exact ranking was not clear, but he hadn't fallen out of this level for a long time.

Not only are they clinical, but they are also very in-depth in scientific research. Whether it is basic research or clinical research, they have carried out extensive and in-depth research.

"The teachers are so powerful, I believe the final result will be very good." Lu Cheng replied.

Sure enough, the family members are better at talking, and they are willing to help you.

In the previous training plan, Lu Cheng just talked to Nie Yayun, and Nie Yayun really did it, and also promoted it. Today's standard treatment regimen is still the same.

There is a saying that goes well, looking at the entire department, the people in each department are united.

Looking at the entire Shashi, Xiangya Hospital and Second Xiangya Hospital are one each, fighting each other in the arena.

As long as they are out of the province, then the three hospitals in the Xiangya system are the three brothers who broke the bones and connected the tendons.

"Well, I hope so too."

"Also. I have already made the plan for the breakpoint regression design. You said it would be better for me to find someone to write the code. Or should you find someone to write the code?" Fang Nixin knew that Dong Zhen could write code .

But Dong Zhen's current task is heavier, so she can't stop the project Dong Zhen is currently working on.

"Find someone to write about. I just checked the progress of Dong Zhen's experiment. She is running WB! There is also fluorescent labeling of specific RNA to be done. In the past two days, there may be no time to spare." Lu Cheng said.

The more in-depth the research, the more in-depth to the micro-level, the more complicated it becomes.

Let's put it this way, if Lu Cheng's workload from discovering VI to breaking its genetic sequence is 1, then he needs to microscopically find one of the pathways and complete all the experiments on this pathway. Then the workload is at least 10 or more!

This is a new sequence. To find a specific marker, it will take a while, and a specific binding antibody must be set.

If there is no similar tool or kit in advance, you have to design it temporarily, which is much more difficult than simply identifying the genotype during sequencing.

The steps are extremely complicated, and at this critical moment, some genetic testing companies may be required to help.

Not easy!

The more this was the case, Lu Cheng knew what Huang Jing and others were worried about.

Cell experiments are not easy to do, so I will use drugs directly, and if prompted, I will do animal experiments.

Isn't this simply killing small animals?

Before the basic experiment started, UU www.uukanshu.com began to conduct animal experiments. Even if animal experiments have certain significance, the basic experiments are completely different. What is the significance?

There are many such examples.

Some drugs that were effective in animal experiments and had minimal side effects were permanently suspended during the first phase of clinical trials.

All the previous research was in vain.

…

"Okay, then I'll go find someone, and I'll send him the corresponding plan."

"You can rest assured that the person I am looking for will not reveal the secrets of our research group." Fang Nixin said.

Lu Cheng doesn't really care: "Let's leak it, as long as we can get a good result in the end."

"As for whether our research group went out, I really don't care."

Fang Nixin immediately replied: "You are generous, you are now full of fame and fortune, your students, and those members of your research group are still just a blank sheet of paper?"

"If it's something our research group can do and it won't waste time, why should we let it go?"

"The results of wisdom and the direction of research are all very precious. But not everyone is willing to throw them out like you."

Lu Cheng sighed back: "The main reason is that there are too many paths to complete. This is the path I have already selected. If none of these paths are effective, then I have to find another suitable path."

Although Lu Cheng felt that the best paths were in these paths, he was not quite sure.

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