Into Unscientific

Morten L.Grobe, translated into Chinese can be called Morten. L. Grobe.

He is a Swede, aged 59, and works for the prestigious Cold Spring Harbor.

Although the name Cold Spring Harbor sounds like a port at first glance, it is actually one of the holy lands of life sciences in the world.

If there are still readers who have not sold their biology textbooks as scraps, they can open the chapter on DNA and find the discoverer of the DNA double helix structure, and you will see a handsome guy named Watson.

Yes, he's been working here before, and he hasn't had a fart yet.

Of course.

In 2019, Watson was deprived of his honorary title due to some reasons, and he will not comment on the specific right or wrong. In short, it is similar in nature to Rowling, the author of Harry Potter, and the direction of speech is opposite.

The line of sight returns to the original place.

It goes without saying that Cold Spring Harbor's scientific research capabilities allow a boss of Watson's level to join them.

Regardless of the military research institutes in various countries, Cold Spring Harbor can be firmly ranked among the top five among all life science research institutes.

And Morton can own a laboratory with the same name in such a research institute, so his resume is naturally extraordinary.

Morton L. Groby, graduated from the University of Pennsylvania, is a lifetime honorary academician of the Swedish Academy of Sciences, and a foreign academician of the Eagle Sauce Academy of Sciences.

In 2017, he won the Lasker Award for his research on histological cells, and is currently one of the top leaders who have the best chance of winning the next Nobel Prize.

A few months ago, due to some physical reasons, Morton temporarily returned to his hometown in Sweden, a small town under Vasteras, Sweden.

Although with the development of science and technology, many small towns in Europe are gradually becoming modernized, it is difficult for even the most developed small towns to have top-notch scientific experimental equipment.

Therefore, Morton, who is unable to conduct high-tech scientific experiments, in addition to taking care of his body every day, also occasionally takes on the work of reviewing journal papers.

Not long ago, he received a call from an old friend.

After the long-lost greeting, the other party expressed the hope that he could act as an external review editor for one of his student's papers.

Morton actually refused at the beginning, after all, no matter what he was doing for a Ph.D., he couldn't match up with a journal like NAR.

But after some haggling, the Lasker Award winner was finally bought at the price of five catties of two Vitex twigs plus bacon. Among them, fried bacon with two Vitex twigs is the favorite.

But the bribe is the bribe, he still told his old friend one thing very seriously:

If the quality of the paper is not good enough, he will not agree to pass the review!

The old friend readily agreed to this, and there seemed to be an inexplicable meaning between the lines, as if in the

show off?

And just a few days after they reached an agreement, an email arrived in Morton's mailbox as promised.

"Common Pheromone Binding Proteins"

Morton read the title of the thesis lightly, and made a rough judgment on the content of the thesis:

"The synthesis idea of ​​the fourth-generation imidacloprid? This is a bit interesting."

Morton once did a project in 2014, the content was the synthesis of the pheromone of the small white moth, and the results were also published on Medicine.

Later, with this patent, he won the title of lifelong director of the Eagle Sauce Agricultural Association and a license fee of three million dollars for five years.

In addition, many of his students and acquaintances work in top biomedical companies, so Morton's understanding of imidacloprid is actually quite in-depth.

"Cockroaches belong to the order Blattata and the family Blatella, and are worldwide urban pests."

".In the process of most cockroaches looking for a mate, mature female adults release two types of sex pheromones: the volatile pheromone bladiaquinone (3,6-dioxane-1,4-diene-1 -yl) methyl ester), and the two contact sex pheromones 3,11-dimethyl n-hexacosan-2-one and 3,11-dimethyl n-n-nonacosan-2-one". "

"Based on the transcriptome data of antennae and other tissues measured by Periplaneta americana, this paper uses the tissue expression profiles of 109 OBPs to screen out two candidate PBP genes with high expression in male antennae, Bger OBP26 and Bger OBP40"

"Subsequent use of in vitro protein expression and purification to obtain high-purity recombinant proteins of the two OBPs"

"".The binding ability of two OBPs to three sex pheromones and their analogs was studied by small molecule fluorescent competitive binding experiments"

After reading the abstract of Xu Yun's thesis, Morton faintly doubted his initial judgment:

The content of this paper seems to be more than just the fourth generation of imidacloprid.

After all, if it is only synthesized with pheromone, there is no need to discuss the related issues of 3,11-dimethyl n-hexacosan-2-one, right?

With this mentality, he continued to read the text.

After just a few glances, Morton's eyes lit up:

"Cyclization (cyclization)? Or use a transition metal? Good idea!"

Then he read line by line, but paused for a few seconds at the link of 5-epoxy-1-hexadecyne:

Xu Yun did not describe in detail the changes of 5-epoxy-1-hexadecanyne at a constant temperature, and the attached diagram is also slightly more concise. Rooted in general.

But Morton didn't care too much. After all, it was just an intermediate link in the transition, and the follow-up was the key.

"LTHF"

"Zoint Primer"

Morton just looked at it row by row, becoming more and more fascinated.

When it comes to scientific research papers, many people may have doubts:

Since advanced technologies are kept secret, why are there still so many so-called scientific research papers published?

the reason is simple.

For one thing, most of the publishers apply for patents before the papers are published.

That is to apply for a patent first, and then publish a paper, so that you can legally guarantee your own interests.

The second is that the content of the paper does not blindly disclose all information.

The papers are usually some theoretical things, such as the principle of chemical reactions, the main components of materials (very low but very important components are usually kept secret), the metallographic structure of alloys, and so on.

These are all things that can be made public—or whether they are made public or not, competitors can get relevant information by analyzing the product.

There are some key pieces of information left that papers usually don't touch:

For example, key process parameters, temperature, pressure, composition ratio, catalyst composition and state, etc. are kept confidential.

In addition, papers are usually in the state of the laboratory, not the state of mass production. The state of small batches in the laboratory and the state of industrial production are two completely different things.

Therefore, the paper often expounds an idea, and few people will tell the whole core technology, and the third brother once revealed it foolishly.

Of course.

Mathematics papers are excluded.

Four hours later.

Morton let out a breath of emotion, and a look of excitement suddenly appeared on his face:

"Bayer's D.E laboratory. Morishita Pharmaceutical's Kameno project team Roche's AIRC laboratory.

If I remember correctly, these laboratories are currently developing the fourth-generation imidacloprid or dinotefuran, and the funds invested are not in the decimal place.

Tsk tsk, now there is a good show to watch. "

Then he put his gaze on the author column, and for the first time looked at the name squarely:

"First author."

"Xu Yun."