My Life Simulator

High-precision laser processing technology has been successful.

Putting aside those great strategic significance, purely in robotics, the bottleneck of the reducer no longer exists.

Next, Lu Li plans to overcome another difficulty - the servo motor.

However... things are unpredictable.

Just when Lu Li was about to invest in the research of servo motors, he unexpectedly learned a piece of news that forced Lu Li to change his research direction.

That evening, Lu Li returned to Fudan's dormitory and finished dinner with Liu Qin.

"Lu Li, do you still remember Wang Yan?"

Liu Qin took a chopstick for Lu Li and looked up at Lu Li.

"Wang Yan?"

Lu Li pondered for a moment, and with his strong memory, he immediately let Lu Li rummage through the depths of his memory to find his past memories.

Wang Yan, Lu Li's high school classmate.

When Yucheng No. 1 Middle School, Wang Yan was still Liu Qin's roommate.

"Wang Yan, old classmate!"

Lu Li smiled and said to Liu Qin, "Back then, when you were in Yucheng No. 1 Middle School, Wang Yan was still at the same table with you! Why, did you suddenly mention Wang Yan today?"

"Wang Yan..."

Liu Qin sighed, "She's ill, terminally ill! She called me this morning and cried so hard. I felt very uncomfortable listening to it."

"Sick? What's wrong?"

Lu Li put down his chopsticks and asked Liu Qin.

"AIDS!"

Liu Qin sighed and shook his head, "She found a boyfriend, but..."

"So it is."

Lu Li also sighed and said to Liu Qin, "Wang Yan called you to ask me for help, right?"

It's not hard to guess.

Lu Li is the top genetic scientist in the world today, and has also made major scientific research achievements in the field of medicine to conquer cancer.

If anyone could possibly conquer AIDS, perhaps only Lu Li could do it.

Wang Yan found Liu Qin and wanted to ask Lu Li for help, which was normal.

"Wang Yan must have wanted to ask for your help."

Liu Qin nodded and said to Lu Li, "Lu Li, Wang Yan... It's very pitiful. If you can help, you can help her! Besides, conquering AIDS is also a major scientific research achievement!"

"You have so much confidence in me?"

Lu Li laughed, "AIDS is one of the five major terminal diseases in the world. Do you think I can find a cure for AIDS in a short period of time?"

"I must have confidence in you!"

A smile appeared on Liu Qin's face, "You are the top genetic scientist in the world. If you can't do it, no one can do it."

"Haha! I love hearing this!"

Lu Li laughed, "Okay! I'll put the project in my hand first, and turn it over to study the treatment plan for AIDS!"

"Thank you! I thank you for Wang Yan!"

Liu Qin's face was full of joy, and he quickly took out his phone and dialed Wang Yan. After the call was connected, Liu Qin said to Wang Yan, "Wang Yan, I told Lu Li. He will find a way to help you."

"Thank you!" On the phone, Wang Yan burst into tears.

...

The next day, Lu Li came to the laboratory of Fudan Medical College again.

In the laboratory, Sister Wen Wan and other graduate students are still working on the human genetic testing project, and the results are not far away.

Lu Li didn't bother them either, and turned to another laboratory to study HIV.

HIV, which is a retrovirus, mainly invades T cells in the body's immune system, thereby destroying the body's immune system.

This is a typical virus intrusion mode.

HIV invades T cells, and then transcribes and replicates in T cells to generate countless HIV, which spreads in a large area, kills T cells in a large area, and completely destroys the human immune system.

At present, according to the WHO report, there are nearly 40 million AIDS patients in the world, 2.7 million new infections every year, 2 million people die of AIDS every year, and an average of tens of thousands of people are infected with AIDS every day.

In my country, there are nearly one million AIDS patients, covering all provinces, municipalities and autonomous regions in the country.

AIDS is very dangerous. To date, there is still no real cure.

This time, because of Wang Yan's incident, Lu Li devoted himself to the research on the treatment of AIDS.

In fact, this is not only for Wang Yan, but also a major scientific research benefiting the whole world.

in the laboratory.

Sitting in front of the test bench, Lu Li carefully observed the process of HIV invading T cells through an electron microscope.

On the display, HIV invades the nucleus and breaks down into RNA gene transcription information.

Immediately, this HIV gene transcription information is quickly combined with the DNA molecular chain in the T cell. The gene transcription mechanism is deceived, so that the DNA transcription mechanism generates HIV DNA molecules according to the transcription information.

Non-stop transcription, non-stop production of HIV DNA molecules. Until the entire T cell is filled with HIV.

By this time, the T cells are dead and all nutrients are used to generate HIV.

Next, thousands of HIV, seeping out from the dead T cells, spread continuously, invading other T cells like crazy.

This is the mechanism of HIV infection.

In fact, the infection mechanism of all viruses is exactly the same as this one. They combine the genetic information of the virus with the DNA of the cell, continuously replicate, continuously generate new viruses, and continuously invade other cells.

For T cells, Lu Li has done a lot of research.

When he was researching cancer treatment plans, the CAR-T anti-cancer technology developed by Lu Li used the immune function of T cells to kill cancer cells.

Now, on AIDS, the weapon that Lu Li used at the beginning has become the target of virus attack.

To treat AIDS, Lu Li still starts from genetics.

In today's world, all HIV treatment programs are unsuccessful, at least not completely curable.

From a genetic point of view, Lu Li has already thought of a solution to HIV, and it is a method that already exists in nature.

In nature, a war that has lasted for hundreds of millions of years is breaking out all the time, and it is breaking out around us.

This is the war between bacteria and viruses.

When a virus invades bacteria, it is no different from invading human cells. It also transcribes the gene information of the virus and combines it with the DNA molecule of the bacteria.

In the war between viruses and bacteria for billions of years, bacteria have evolved a defense mechanism to fight viruses.

This gene sequence, called "CRISPR", is a repetitive sequence in the prokaryotic genome. It is an immune weapon produced by bacteria and viruses in the history of evolution of life.

In short, bacteria evolved the CRISPR-Cas9 system in order to remove the foreign invasion genes of viruses. Using this system, bacteria can silently excise viral genes from their own genomes, a bacterial-specific immune system.

In fact, the gene editing technology in the world today is based on the gene cutting technology developed by this CRISPR-Cas9 system.

Now, Lu Li's idea is to use the CRISPR-Cas9 system to arm T cells.

Once HIV invades T cells, the CRISPR-Cas9 system will cut off the genetic information of HIV, thereby preventing HIV infection.

If the technology is successful, a vaccine against HIV infection could be created.

Of course, the technology is still therapeutic enough for patients who are already HIV-infected.

T cells in the human immune system can continue to replicate and proliferate. If the newly born T cells all have the ability to fight against HIV, then... even if HIV kills all the original T cells, it cannot invade the newly born T cells.

This way, HIV cannot destroy the body's immune system. The remaining HIV will also continuously infiltrate new T cells because of the virus, and will be cut off by the CRISPR-Cas9 system constantly, and eventually all die.

In theory, this idea is achievable.

Now it depends on whether the experiment can be successfully completed and whether this CRISPR-Cas9 system can be equipped into T cells.

"Open the virtual lab!"

With a thought, Lu Li directly opened the virtual laboratory, preparing to do research in the virtual laboratory.

"Virtual AIDS patient."

Lu Li was going to do human genetic experiments directly. This kind of experiment is not easy to do in reality, but it is very convenient to do it in a virtual laboratory.

After imagining an AIDS patient, Lu Li picked up the syringe and took out a hematopoietic stem cell specimen from the patient's spinal cord.

T cells in the human immune system are transformed from hematopoietic stem cells under the induction of thymic hormones.

The research that Lu Li is doing now is to equip the CRISPR-Cas9 system when hematopoietic stem cells are transformed into T cells, so that the newly generated T cells have cell-level immune functions.

It is not difficult to equip cells with the CRISPR-Cas9 system.

When doing gene editing, it is necessary to inject the CRISPR-Cas9 splicing protein into the cells that need to be cut and edited.

The real difficulty lies in how to make the hematopoietic stem cells produced in the spinal cord automatically generate immune T cells according to a new template during the process of converting them into T cells.

This again involves RNA gene transcription information.

Lu Li must also express the armed T cell genes in the form of RNA gene transcription information, so that hematopoietic stem cells can replicate according to this new template.

Fortunately, with Lu Li's current genetic knowledge, it is not difficult to do this.

Next, Lu Li extracted the gene information target of AIDS, added it to the gene target of the CRISPR-Cas9 cleavage protein, and then injected it into T cells, combined with the DNA molecular chain of T cells, and then injected transcriptase to generate new gene transcription information.

The newly generated gene transcription information is extracted, injected into hematopoietic stem cells, and combined with the DNA molecular chain of hematopoietic stem cells.

So... in hematopoietic stem cells, according to the new gene transcription information, new DNA molecular chains begin to be generated to generate new immune T cells.

At this point, the experimental process has been completed 90%, and the next step is to see the real treatment effect.

Lu Li cultivated hundreds of millions of hematopoietic stem cells, reinjected them into the patient's body, and transformed them into new armed T cells through the thymus.

After waiting for several hours, Lu Li extracted lymph fluid from the patient's body for testing.

It turned out that ... the newly generated T cells with the CRISPR-Cas9 system had emerged in large numbers.

In these T cells equipped with the CRISPR-Cas9 system, the viral gene information of HIV invasion is all targeted by the target information of the CRISPR-Cas9 system, which directly shortens the genetic information of HIV, and successfully kills one HIV.

The immune system is still generating new T cells. These new T cells are all new T cells equipped with the CRISPR-Cas9 system, all of which can kill the invading HIV.

After a round of replacement of T cells in the patient's body, once HIV invades the new T cells, it will be destroyed one by one, and eventually disappear completely.

This process... lasts about one to three months, and within six months at the longest, HIV will be completely killed.

Of course, HIV in these patients is still highly contagious until they are completely cured.

It took two weeks in reality and more than four months in the virtual lab. This virtual AIDS patient was completely cured.

Lu Li carried out a detailed test on this virtual patient, and the presence of HIV was no longer found in the patient's body.

The experiment was successful!

Next, Lu Li repeated the genetic experiment in reality. Human experiments have yet to be done in reality.

After repeating the genetic experiment in reality, the following time is the time to write a paper and pretend to be forceful.

"A CRISPR-Cas9-based AIDS treatment regimen."

In this paper, Lu Li wrote all the theoretical expressions of CRISPR-Cas9 technology, and theoretically demonstrated the feasibility of using CRISPR-Cas9 technology to edit and modify T cells for the treatment of AIDS.

Of course, in this paper for public publication, there is naturally no detailed experimental data or detailed operation steps. It is just a theoretical demonstration.

Another technical document with detailed data and experimental steps was sent directly by Lu Li to the Institute of Medicine, Chinese Academy of Sciences.

The published papers are submitted to the international authoritative medical journal "The Lancet", and the papers are also posted on the academic network.

So...Professor Lu once again became famous all over the world.

"Omg! Professor Lu has developed a treatment plan for AIDS!"

"Has Professor Lu finally remembered that he is a medical scientist?"

"The great medical scientist who conquered cancer has conquered AIDS."

"This is a great achievement! Tens of millions of people living with AIDS around the world have ushered in their redemption."

"Is AIDS not bothering humanity anymore? That's really good news."

"The Nobel Prize in Medicine belongs to Professor Lu. No one is eligible to receive the Nobel Prize in Medicine except him."

"There is one less terminal disease that plagues mankind. Even the most demanding person must admit that Professor Lu is the greatest scientist in the world."

The scientific and medical circles expressed warm appreciation for Lu Li's achievements in overcoming AIDS.

Even... foreign media are fully advocating.

Professor Lu has such a high talent in medicine, of course, he should focus his energy on medical research to benefit all mankind. Don't be distracted by other science and technology.