Rebirth of the God-level Xueba

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"We now know that the structure of g protein-coupled receptors is a transmembrane structure composed of seven a-helices. Not only that, but some of its receptors also contain extracellular n-terminal or intracellular c-terminal structures . This makes the structure of G protein-coupled receptors extremely complex."

Yang Rui held the microphone and spoke his point of view slowly.

Below the podium, there are nearly 300 scholars sitting densely, as well as the corresponding academic media.

This was originally just a project application meeting for the 863 program. Somehow, the scale increased from 9 judges to nearly 300 people.

In fact, Yang Rui knows what's going on. This is a project application for g protein-coupled receptors. If scholars in related fields are not curious, then the Chinese academic community will be considered to have collapsed.

If you want to give a metaphor that conforms to the habits of the public, in China in 1986, applying for the "g-protein coupled receptor" project is like holding a project review meeting at the space agency, and the project reviewed is "Sirius Landing and Colonization Plan" ".

Of course everyone knows that the landing and colonization of Sirius cannot be accomplished overnight, or even impossible at all. However, since the applicant is the famous "Yang Rui", then, even if it is to know what the prospect will be in 300 years , everyone is still willing to come and listen.

In fact, the difficulty of thoroughly studying what is going on with g protein-coupled receptors is different from the colonization outside the solar system. It is really difficult to say who is difficult and who is easy.

Even if Yang Rui just took a small step, it was enough to make everyone listen.

However, Yang Rui didn't just want to take a small step.

Holding the microphone, he looked at the crowd below. These people, who may represent the highest level in China's protein field, said in a clear voice: "Some structural biology studies have obtained lower-resolution structures, allowing us to see the g The general orientation of protein-coupled receptors, however, these structures are too rough and there are too many problems that cannot be explained."

"I want to explain some of the problems." Yang Rui was neither arrogant nor humble, and said, "The problems I want to explain are as follows. First, why is it the same seven transmembrane structures that g-protein coupling is subject to? Why can hundreds of different molecules in the body family specifically recognize substrate molecules ranging from photons to proteins, and these substrate molecules have huge differences in shape, properties and volume."

"Second, I want to know about the signal transmission of the receptor."

If,

When Yang Rui said the first point, the scholars present could still watch him perform with a smile, but when they heard the second point, everyone started talking about it.

Because Yang Rui basically raised two different questions, with different directions.

Research structure, or research signal, these are two links and two levels of difficulty.

Those who do structure will not go to do signal, and those who do signal will not go to do structure. Although they are all in the field of protein, they basically belong to two branches. Moreover, it is difficult to compare the two. Why? Want to do it at the same time?

Including 9 high-level scholars who are judges, they are all frowning and looking at Yang Rui.

Yang Rui just pretended not to see him.

Of course he knows that the two problems of structure and signal transmission are very difficult.

In fact, making any of them could lead to a Nobel Prize.

The combination of the two is a complete Nobel Prize - according to the "Nobel Prize Foundation Statutes", the Nobel Prize can be awarded to 3 people at the same time. In the fourth section of the "Charter", it is stipulated as follows: "Awards may be awarded for two works, each of which is deserving of the award, and if two or three persons have done a deserving work together, the award should go to them both. But in either case, No award can be awarded to more than three persons at the same time."

Before the 1980s, or earlier, before the 1960s, the Nobel Prize was often awarded to one or two people. However, with the development of science and technology, the importance of the Nobel Prize is also increasing. It is the norm for three people to award awards.

For example, what Yang Rui is doing now, the structure and signal of g-protein coupled receptors, should have been shared by American scientists Lefkowitz and Kebilka.

But that was 2012.

Since Yang Rui chose the mode of research in advance, he naturally doesn't want to play any sharing mode anymore.

Furthermore, the structure and signal are made together, so that people can roughly understand the g-protein coupled receptor, and both are indispensable.

If Yang Rui only does one of them, it is still uncertain when he will win the Nobel Prize.

G protein-coupled receptors are different from other fields, because this field is too difficult, so accumulation is of course needed, but sometimes it depends on luck and inspiration.

Therefore, the Nobel Prize in 2012 and the Nobel Prize in 2002, and even the Nobel Prize in 1992, are not too far away, at least for Yang Rui, it is not an insurmountable distance.

Of course, the chances of this thing winning the prize are also very high.

For the normal Nobel Prize, it is normal to wait ten, eight, or twenty years to win the award. The unlucky ones who have not waited until the death light goes out have not yet received the award, and the faster ones are PCR. Wait a few years for a chance.

However, G protein-coupled receptors are amazing. As far as the 12-year version is concerned, the results were achieved in 11 years, and the awards will be awarded in 12 years.

No way, this thing is too domineering.

Of course, this does not mean that the creation of a G protein-coupled receptor will definitely win the award the next year, it can only be said that it adds another weight.

Swiping for the Nobel Prize is the same as playing the magic costume.

You know that the boss will have a magical appearance, the ultimate boss has a high probability, the big boss has a low probability, and the small boss has a probability, so the correct way to brush is not to brush an ultimate boss and then look at the face, but to pile up bosses to pile up a mountain of corpses. That divine attire will eventually fall into your hands.

Yang Rui is not very confident in luck, but he is quite confident in his ability to defeat bosses.

After speaking a few more points, Yang Rui returned the microphone to today's host and recommender of the project, Academician Zhu.

"Thank you, Comrade Yang Rui. Next, if you have any questions, please ask the judges." Academician Zhu's voice was lazy, and his eyes were curiously rolling on the faces of a group of people.

He wondered how many people really understood.

The judges all sat up straight, and several of them made their voices at about the same time.

"You go first."

"You ask first."

"After you."

Several people gave way again and again.

Afterwards, Professor Qian, who was sitting in the middle of the judges, said, "Yang Rui, your plan looks good, isn't it a little too ambitious?"

"It is indeed a grand plan, but I am confident that I can complete this plan through the Ion Channel Laboratory of Peking University and prove that the Ion Channel Laboratory is a world-class laboratory."

Wow.

The scholars in the stands began to discuss again.

Yang Rui just nodded slightly, looked at Academician Zhu, then turned around and said, "Peking University's ion channel laboratory has raised 6 million US dollars and 2 million yuan in funding. This time, we are applying for 3 million yuan from the 863 Program." The total funding is also to enhance our strength..."

Yang Rui showed his sharpness, and he didn't have any intention of being modest.

Stand on the kingly road and rush forward, everyone will see you, no matter how timidly you hide, you will not be able to hide.

And the sharpness of using 6 million US dollars as a corner is really irresistible to many people.

Professor Qian couldn't help but quietly sat down.

If he asks a question now, he will only humiliate himself.

"Next, does anyone have any questions?" Academician Zhu asked softly.

The nine judges shook their heads in unison.

"Then let's vote now, those who agree to approve the project and the requested amount, please raise your hand.

The nine paws were raised together.

"Okay, I announce that the first project of the national high-tech research and development plan, the structure and signaling of g protein-coupled receptors, has been officially approved, and the person in charge is Yang Rui from Peking University..." Before academician Zhu could finish his sentence, there was soft applause rang.

Louder and louder, louder and louder.