Rebirth of the God-level Xueba

"Show me your experimental records."

"How are you doing so far?"

When Yang Rui came to the laboratory, he asked all the way. He seldom did this, in fact, very few heads of large laboratories would do this, partly because of lack of time and partly because of lack of ability.

It is obvious that there is no time. The person in charge of any large laboratory is a busy guy. They either spend their time in the laboratory or use their time to raise funds. If anyone wants a If the head of a high-level laboratory hangs around him all day, he'd better be The Flash or something.

Insufficient ability is another kind of helplessness. The work of the laboratory is no longer a known work. No matter how easy the work of the scientific research dogs is, they are still on the edge of the unknown world. If the head of the laboratory can explain all the problems, he will also There is no need for scientific research dogs to do experiments desperately. Therefore, the unknown problems encountered by scientific research dogs are also unknown problems for the laboratory director. Maybe the latter has more experience to solve these problems, but it also needs It takes a lot of energy and time.

Therefore, the more high-end the laboratory, the less the person in charge of the laboratory will provide hands-on guidance.

Give systematic training, point out the direction of development, provide cutting-edge information, and have high-level senior brothers, basically the person in charge of a high-end laboratory can provide the most valuable things. Of course, if you think more secularly, high-end laboratories have richer experimental resources and social resources, which is also a big plus.

However, Yang Rui is not an ordinary laboratory leader.

Facing the unknown world of science, the heads of other laboratories, perhaps like scientific research dogs, are waiting for the results of exploration with their eyes darkened. In the best case, they are just holding up candles to search.

But for Yang Rui, the scientific world in the 1980s was brighter and clearer than the playground under the sun at noon.

Therefore, he is indeed capable of doing hands-on guidance.

However, in the past, Yang Rui would not do this. It was mainly because he was not confident enough. In addition, he did not understand the details, especially the details. It was only after several years of high-intensity laboratory life that Yang Rui had a high level of detailed domain control.

The most important point is that there was no need to guide the scientific research dogs by hand.

If a dog with 0 offense and 0 defense can already conquer the world, why use a lot of resources to upgrade it? Just like the enemy's tanks only have 40mm armor for defense, our side already has anti-tank weapons with 60mm penetration,

It is obviously not a top priority to produce anti-tank weapons with 100 mm penetration.

until now...

If we study PCR, the scientific research defense system encountered is 40 mm of armor, and the defense system of G protein-coupled receptors is about 400 mm of armor.

The defense level of PCR is the defense level of small Japanese tanks, and the defense level of G protein-coupled receptors is a proper sea battleship.

And the three-dimensional structure that Yang Rui is trying to make is almost equivalent to the core part of the battleship G-protein coupled receptor. You can't be fooled by buying 400 mm of reinforced armor, and you can't buy it to suffer...

Facing such a powerful enemy, it would be impossible not to upgrade the scientific research dogs.

Especially when encountering a scientific research dog like Wu Qi, Yang Rui decided to start with the most powerful one since he wanted to develop talents and provide resources.

Yang Rui is an experiment record, and after reading an experiment record, he pointed out mistakes and gave directions casually.

"Control your reaction temperature."

"You need to think more about the use of solvents. Why is the concentration set at the current value? Do you have to use these types? What is the basis for your choice?"

"Big mistake, start over!"

It took Yang Rui a whole morning to kill a pair in the laboratory.

The students in the laboratory were fine, but the professors who joined the laboratory not long ago were shocked by Yang Rui.

Since His Excellency Liebig, the teaching mode of high-end laboratories has not changed much in the past 100 years. In those days, the Giessen laboratory always compressed the theoretical teaching to a minimum, guiding students to do experiments most of the time, and using Train them in three steps. The practice of delegating the teaching of beginners to skilled students is exactly the same as that of postgraduate education in later generations.

Now, Yang Rui did the opposite.

When he got to Wu Qi's side, Yang Rui stood still and refused to leave.

"There is no problem with the operation, what do you think of the results of this experiment." He watched Wu Qi complete a set of experiments, and then asked.

Wu Qigang straightened up, breathed a sigh of relief, and felt overwhelmed, so he quickly turned his head and said, "From the analysis of this substrate experiment..."

"Don't analyze it from one experiment. You have done experiments for so many days, what do you think?" Yang Rui interrupted Wu Qi instantly.

Wu Qi was stunned for a moment, and couldn't help hesitating. Needless to say, it is difficult to analyze one experiment or a bunch of experiments. Moreover, he was not prepared to say it all at once.

Yang Rui waited quietly for a few minutes. He had higher expectations for Wu Qi, so he also made super high demands.

However, Wu Qi didn't seem to have entered the state yet, looking like a statue with his head down.

Yang Rui didn't feel disappointed, but felt a little surprised.

"in this way……"

"I think……"

When Yang Rui spoke, Wu Qi happened to raise his head to speak.

"You go ahead."

"You go ahead."

The two spoke in unison again.

Yang Rui couldn't help smiling, shook his head, raised his chin, and motioned: "Did you figure out the result?"

"Some ideas..." Wu Qi didn't dare to speak too much.

"you say."

"Yes." Wu Qi thought for a while before saying, "I recently did an experiment and paid more attention to hydrogen bonds."

Hydrogen bond is a common intermolecular force. In junior high school, the value is basically equal to a "-", but in advanced research, hydrogen bond is very changeable.

Yang Rui didn't expect Wu Qi to speak from this angle, "Oh", said: "Tell me about it."

"Yes." Wu Qi paused again, and said: "I read some literature, and believe that the directionality and saturation of hydrogen bonds are the driving force that causes the association of the acceptor and the substrate, and then forms a complex, and causes important reason for molecular recognition."

Yang Rui nodded slowly: "The G protein-coupled receptors we are making now focus on molecular recognition."

"Yes. So I have paid more attention to hydrogen bonds recently. I think that if the classification of substrates is considered together with the factors of hydrogen bonds, some substrates should be able to be screened out. These substrates should have a higher probability. Used in the analysis of conformation." Wu Qi spoke very slowly, and even a paragraph was broken into several sentences by him.

However, what Wu Qi said was indeed worth thinking about, including Yang Rui, who also listened very seriously.

Moving toward the right goal, it may be "one road from Huashan Mountain since ancient times", or "all roads lead to Rome". In the case of limited funds, resources and scientific basis, the former is more likely to appear than the latter, but , after canceling various restrictive conditions, the possibility of the latter will increase.

What Wu Qi proposed is exactly a road that Yang Rui has never seen anyone go through—in fact, it can’t be regarded as not going through. Scholars need to make the conformation of G protein-coupled receptors. They have chosen some methods, which do not include hydrogen Bonding way, later, the conformation of G protein-coupled receptors is completed, whether there are other methods or ways to reach the goal of conformation, it loses its practical significance.

As for now, Yang Rui felt that he could take a step forward.

Anyway, with so many scientific research dogs under his command, it would be nice to send a smarter one to explore the way.

Thinking of this, Yang Rui nodded slowly, and said: "You write a report to me and explain your thoughts. Will you write this kind of report?"

"I will." Wu Qi nodded excitedly, submitting a report directly to the laboratory director is a step up to the sky for a scientific research dog.

Yang Rui nodded and said, "I'll give you a separate fund, about 10,000 yuan. After the report is written and approved, you can try the hydrogen bond method alone. If it can be done, you will be allowed to sign and publish the paper alone. Of course, if you can't do it, then go back to the normal route."

"I will make it." Wu Qi suppressed his mood, full of the heroism of a scholar who is a confidant.

...