Rebirth of the God-level Xueba

Pharmaceutical companies are very self-willed in the Jinyuan world. If Yang Rui is Chinese-American or something, let alone discuss business with Pfizer, he can be recruited by Pfizer thanks to the Lord Long En.

If it doesn't work out, a group of lawyers will pounce on you and make you doubt your life.

Today, Yang Rui is the head of the ion channel laboratory, the owner of Huarui Laboratory, the first of Yang Rui's genetic engineering laboratory, the inventor of PCR, the pioneer of the human gene era, the king of G protein-coupled receptors, A breakthrough in ion channels, a Nobel Prize winner, the real king of genetic engineering, the controller of cow embryos, the maker of Chinese medical standards, the pioneer of the 863 plan, the savior of millions of patients with arrhythmia, Chinese and foreign media The male god, the father of cloned sheep, the terminator of thalassemia, the expander of coenzyme Q10, the lightning rod of the Chinese scientific community, the supreme monarch of sixty-four experimental dogs...

As a pure Chinese and a Chinese scientist, with the backing of the big tree of China, he can doubt life with foreign companies and state-owned companies every minute, and can also formulate policies to make pharmaceutical companies that want to develop in China look up at the stars and lament the injustice of the world .

This is the advantage of being a big boss in China, a closed and huge market economy country. Unlike Japan, South Korea and other countries, if you want to implement a drug closure policy, you have to consider the implementation of security regulations.

If you want to say, how strong is the strength of pharmaceutical companies, especially the strength of Jin Yuan? Needless to say, influencing the policies of one's own country, it is also common to influence the policies of other countries. In order to make money jointly with insurance companies, they can change the medical insurance policy, making people die without a place to go.

However, China has never been a country that plays its cards according to common sense.

Even without Yang Rui's intervention, Pfizer would still encounter many problems in China. For example, the name "Viagra" was preempted by domestic companies. As a result, several years of lawsuits were fruitless. Until the end of the patent period, Pfizer could only use Viagra as the name.

Pfizer's problems didn't stop there. After the patent of Viagra expired, domestic Jin Ge raised the banner of competition. In addition to advertising, their most ruthless move was to enter Viagra into the prescription drug industry.

For quite a long time, Chinese who wanted to buy Viagra needed a prescription to buy it, while Chinese who wanted to buy Jin Ge could go to any small pharmacy and get what they wanted as long as they brought the money.

Is this competition legitimate? At least at the policy level, this is the result of competition.

As for whether a drug can be marketed, whether it should be included in the prescription drug list, whether there are any special requirements, whether it can be produced in the country, whether it must be produced in the country, whether it should be further tested and clinical trials, it is ultimately up to various committees. Guys decide.

Facing a market with 1.2 billion people and an average annual growth rate of more than 10%, Pfizer is not willing to offend the boss easily.

Even, in order to make up for the relationship, Pfizer also spent money to hire a China hand, and went to China to discuss with Yang Rui.

"Frankie? Why did you come here on behalf of Pfizer, not at Zeneca?" When Yang Rui saw the representative of Pfizer, he was in a daze for a few seconds.

He hadn't seen the fat British man for a while.

Frankie smiled like a cracked donut, and said, "I opened a special consulting company to provide pharmaceutical companies with services about China, and my income has doubled several times."

"Being your own boss? Great!" Yang Rui gave his old acquaintance Comrade Franky a thumbs up.

He quite liked this fat Englishman. Compared with the usual arrogant and prejudiced foreigners, Franky was much more sensible and communicative.

Franky was able to eat this bowl of rice because everyone liked him.

Seeing that Yang Rui agreed with his choice, Frankie was very happy, so he poked his tongue out in the Chinese he had just learned, and said, "It's all thanks to my brother's support!"

Yang Rui laughed loudly, nodded to Frankie, and said, "Just because of your hard work in learning Chinese, I want to treat you to dinner. Well, go to my laboratory. I will let Mr. Yu take charge of the cooking."

"Chef Yu's craftsmanship is three-star.

"Frankie got greedy when he said that. He was talking about Michelin three stars, which is the highest state.

"That's right, you've eaten the food made by Chef Yu, that's good, no need to introduce, do you want to order?" Yang Rui showed Chinese-style hospitality. He didn't have such a mood for strangers.

"Let Chef Yu come and choose." Franky paused, and said, "If possible, stewed lion's head, I want two."

"Well, there are two stewed lion heads with the size of a fist. Chef Yu can choose the rest. There is one..." Yang Rui looked at Franky's wider figure and said, "There are seven or eight dishes, which should be about the same , a bigger portion."

After listening to the translator's whisper, Franky nodded again and again: "Large portion, large portion is good."

Neither of the two had any intention of discussing business, but Connell, the manager of Pfizer who came with him, was extremely happy, thinking that the six-figure expenses were finally not in vain.

As Chef Yu gets older, he spends less time cooking and thinking more, and the taste of the dishes he cooks is even better.

However, most of the dishes are still cooked by his apprentices.

He is said to be an apprentice, but now he is also a chef. Putting it outside, he is also a small celebrity in the culinary world. Whether it is frying, steaming or cooking, he has his own characteristics.

For example, Franky’s favorite stewed lion’s head, the traditional method is to use a flat knife to cut the pork ribs into pomegranate seed-sized pieces. The optimal ratio is fat, seven, and thin, three. Health factors have already begun to be considered.

The lion head he made is not as fat as the master's. While using a fat-to-thin ratio of 50-50, he also skims the oil with ice water, which not only maintains the tender and Q-bomb taste, but also increases the proportion of lean meat, making the stewed lion head more delicious. The head is healthier and more suitable for people who do not lack meat.

Of course, there is no way to say such things as eating too much because it is delicious.

As for whether it is authentic or not, Yang Rui has long since stopped caring.

Modern people eat famous dishes, and the mentality of pursuing authenticity is the most unauthentic. Authentic can only be said to be in line with the tastes of a generation, or it may be in line with the tastes of a literati and poet. The worst thing is that it is in line with the preferences of people in a region, and there is still a long way to go from being delicious.

From this point of view, eating authentic food is equivalent to queuing up for a tourist to take a photo with the words at the entrance of the scenic spot, and eating for the circle of friends.

"Professor Yang, why did you think of buying sildenafil?" Frankie leaned back on the chair until he couldn't walk, touched his belly with his hands, and asked about the serious matter with a smile.

"I'm optimistic about the prospects of nitric oxide drugs." Yang Rui didn't hide his approval, took a sip of the wine, and spoke slowly.

Sildenafil is an active drug that has been tested for safety in animals. No matter how cheap it is, it costs tens of millions of dollars. If it is not recognized and optimistic, there is no reason to buy it.

Nitric oxide drugs are also the most popular types of drugs in the past two years. The so-called nitric oxide drugs, the most famous is nitroglycerin, which is an ingredient of Nobel’s explosives, and it also has a miraculous effect on angina pectoris, but for a hundred years, people have not known why.

It wasn't until the end of the 1980s, that is, in the past two or three years, that the biological community gradually figured out that it was organic nitrate enzymes such as nitroglycerin that could increase the concentration of second messengers in human tissues, and their production The mode of action is to metabolize nitric oxide.

This is a brand-new signal transduction mode, and it is a deep understanding of human beings about themselves.

The term nitric oxide has become very popular, and in a few years, it will even win the Nobel Prize.

Pfizer also carried out research on sildenafil for this reason. They screened a large number of molecules and finally selected this small molecule compound named UK-92,480.

It can be seen from its naming label that it takes a lot of time to sieve a molecule out.

Although Yang Rui believes that there must be other molecules that can exert similar or stronger effects, but if he is given tens of millions of dollars, or even hundreds of millions of dollars, it is really not necessarily possible to screen them out.

Pfizer is reluctant to put it on the shelf for this reason.

Nitric oxide drugs have just become popular. Now that they are sold, it is really not easy to screen out a usable one that is as safe as this.

However, China is also a big market that has just become lively, and Pfizer is unwilling to find a big obstacle for itself just after opening the door.

Frankie took Pfizer's money, so he naturally wanted to speak for Pfizer. He also took a sip of white wine, grinned his teeth hotly, and said happily again: "Why do you fall in love with sildenafil? Why do you still want it? Didn’t Pfizer ask for prices?”

On the surface, he was speaking for Yang Rui, but he was actually raising the price.

Pfizer still didn't want to sell it, but Yang Rui forced him to come out for a negotiation, so the first choice was to ask for a sky-high price.

Yang Rui was not surprised. He held the wine glass and said, "I chose sildenafil because it has the best safety among nitric oxide drugs. Huarui's first drug, not to mention its efficacy, is safe. Sex is something to focus on."

"Hey, is this the direction of your business?" Franky was immediately misled by Yang Rui.

Yang Rui nodded and said, "That's right. Alright, let's talk about Pfizer's asking price."

"Aren't you in such a hurry to let others charge a high price? Why bother." Franky used the same method again.

Yang Rui leaned back on the chair, put his hands aside, and said with a bossy expression, "Come out and try."

"This..." Franky was immediately shocked by Yang Rui.

His task is very simple, contact Yang Rui, ease the relationship, and make an offer. If he angers Yang Rui, ruins the Chinese market, and Pfizer is unhappy, he will be caught blind.

"Connell, tell me." Franky quickly found a scapegoat.

Pfizer's manager didn't care. He didn't know Yang Rui and didn't have any relationship with him. After hesitating for a few seconds, he said, "If we only sell sildenafil in the Chinese market..."

"There is no such sale. What you are holding now is a compound, not a compliant drug. Could it be that I have developed a new drug and it is only sold in China? Am I crazy?" Yang Rui immediately interrupted Cornell's words .

Developing a new drug will cost hundreds of millions of dollars if it goes well, and there is no reason to sell it in only one place.

If it can cure alien diseases, pharmaceutical companies dare to invest money to restart the Apollo program.

Cornell asked the price wildly, and said with a smile: "You can entrust us with the market outside China..."

"Agent sales is a matter of the future. Now let's talk about the transaction of compounds." Before the effect of the medicine, it is meaningless to talk about it.

Cornell was just talking casually, but at this time he couldn't help but glance at Franky, and then said: "We have spent hundreds of millions of dollars on the development of sildenafil..."

"If you want to amuse me, there is no need." Yang Rui stood up all of a sudden.

"Professor Yang Rui, how about our joint development? If you are interested in sildenafil, we are willing to use an open plan to cooperate with you. The cooperation plan can be very open." Cornell hinted desperately.

For Pfizer, the allure of Nobel Prize winners is also very large.

Especially Yang Rui, he has a precedent of developing new drugs and is successful, and he is also a cutting-edge biologist who has created a G protein-coupled receptor. On the other hand, it can be said that as long as Yang Rui is willing to cooperate and the terms are not too harsh, Pfizer is very interested.

Even if he doesn't make any achievements, when the time comes, the new drug of sildenafil, which is named after a Nobel Prize winner, might be able to sell hundreds of millions of dollars more.

This is also the biggest reason why Frankie can get a six-figure salary.

He immediately chimed in and said, "Professor Yang, this is a rare opportunity. You can put forward any conditions you want. Sildenafil has only been tested on animals, and it is still far away from being on the market. You may sell it by then." , why not start working together now?"

Drugs like deferiprone belonged to a long-term recovery project. Yang Rui was too lazy to spend time on it, so he sold it in a milestone manner.

Even if Viagra wants to cooperate, it is after discovering its true efficacy.

"Find someone who can make a decision and ask him to set a price." Yang Rui was not affected by Franky's words in the slightest, and continued: "I can offer a high price, otherwise, I will buy other types of nitric oxide compounds. If I develop it first, the value of sildenafil will be greatly reduced."

The greatest value of a new drug is that it treats a disease with a new mechanism.

In other words, patients who have not tolerated certain types of drugs in the past may be more suitable for taking new drugs. New patients represent higher sales.

Naturally, if a drug of the same kind is marketed first, the drugs listed later will inevitably be affected. Especially according to the rules of the US FDA, the efficacy of drugs that are listed later must be compared with those that are listed earlier.

If the drug effect is equal or inferior, the drug developed later may not even be marketed. For a company, the hit to the stock price alone is enough.

It was a billion-dollar business decision that Cornell couldn't make.

He immediately bowed his head and said, "I'll notify the company headquarters immediately."

After finishing speaking, he said carelessly: "Mr. Yang Rui, I hope our negotiation will not interfere with Pfizer's business in China..."

"Of course it will interfere." Yang Rui is not a little white rabbit, and said calmly: "Companies that cannot make correct business judgments will not do business well. You can paraphrase Pfizer's leadership."

"Professor Yang, I would like to offer you a toast." Franky was too convinced.

The more domineering Yang Rui is, the more he likes it. It is impossible for Pfizer to give up the market with one-sixth of the world's population. Yang Rui's test is something they have to pass.

Frankie only thinks that his consulting company has great potential.