Rebirth of the God-level Xueba

"Your idea... will face a very important problem. If the US Congress, or any appropriation agency in the country, cannot see our output, the genome project may be stopped..." Dalbecco obviously also I have thought about whether to do technology first or to do sequencing first, but I have not decided.

Yang Rui said: "The Human Genome Project will be very different from other projects."

"certainly."

"If current technology is used, sequencing will be very, very long. Indeed, if direct sequencing is used, with existing technology and tools, we may be able to get some results in the first year, 50,000 base pairs?" Yang Rui disdained He smiled and said: "Our goal is 3 billion base pairs. With the current level of technology, if we don't make a lot of investment, even if the budget is 15 years, we will not be able to complete the entire project."

"But from a Congressional and public standpoint, we got at least 50,000 base pairs, which is a tangible benefit, right? And in the process, we can still continue to develop the technology, and, the sequencing itself , can also help us develop technology, can’t it?”

Yang Rui said without hesitation: "Impossible. Sequencing itself is a physical task. We need to pay attention to the method of sequencing and the results of sequencing. As for the sequencing itself, it is meaningless."

Dalbecco was a little surprised at Yang Rui's arbitrariness, but he was also a person who had been in the front line for many years. After thinking about it carefully, he had to admit: "What you said has some truth. But I think even the Congress will require us to While developing technology, it was sequenced at the same time."

"If I had to choose, I don't recommend it." Yang Rui shook his head and said, "Even if we go all out for sequencing, the results in the first and second years will be ugly. If so, why should we take Come to fruition. I would say that we should not be sequencing even a single base pair in the first year, the second year, or even the third year, except for testing."

Not only Dalbecco, Professor Cai and Tobias were also dumbfounded.

This is the first time that Yang Rui put forward his own opinion, not agreeing with Dalbecco's opinion, but disagreeing with Dalbecco's opinion.

For the relationship between the two people, as well as their future relationship and position, Yang Rui's performance at this time is decisive.

Of course, his opinions are also very decisive.

Dalbeco couldn't help thinking deeply, and after a while, he asked, "Why? By doing this, our pressure will greatly increase."

"As long as the project is established, such a huge project, even those who are eager for quick success, will not ask us to give results in one or two years, right?

Therefore, in the early stage, completely abandon the sequencing of base pairs and focus on technology. I think that although the pressure will increase, it will not increase too much. In the third year, the pressure may increase a lot. At that time, we will do a certain amount base pair sequencing is also possible. "Yang Rui explained softly.

"Is it necessary?\

,""It is very necessary." Yang Rui said: "We do not sequence any base pairs. We can explain to investors or the public that the technology-first strategy we are adopting now, and our current preparations are for faster completion in the later stage. The sequencing of base pairs is more cost-effective. And once we have sequenced, for example, in the first year, we completed the sequencing of 50,000 base pairs, what is the result? Will investors and the public be happy?"

Dalbecco hesitated and said, "Isn't it?"

"Of course not, because anyone knows this simple calculation. It took us a year to sequence 50,000 base pairs, 10 years to complete 500,000 base pairs, and 100 years to complete 5 million. , There are only 50 million sequences in 1000 years, so all the media will come to a conclusion that the Human Genome Project is over." Yang Rui took out the big move he had prepared for a long time.

Dalbecco was stunned, and for a moment, he said: "We sequenced 50,000 base pairs in the first year, but it doesn't mean that our progress will be the same next year. Our progress may be 1 million base pairs in the second year. Maybe 10 million base pairs can be sequenced in three years."

"In this case, why don't we re-sequence in the second year? Ordinary people can't predict the development speed of science and technology. They will use their salary increase to judge technological innovation, such as 10% progress, or more, doubled progress, but no one would believe a 20-fold increase, and if I were to judge, a 50-fold increase would be possible.”

"You mean, by adopting a technology-first strategy, you can achieve 50 times the previous rate in one year?"

"That's right, and only by using this method can we complete the genome project as quickly as possible and gain a competitive advantage." Yang Rui actually felt a little emotional in his heart. The Human Genome Project has been carried out for more than ten years and spent more than 2 billion US dollars to complete the sequencing of 2.3 billion base pairs of the human body for the first time.

However, by 2015, the cost of sequencing 2.3 billion base pairs in the human body has been reduced to $99, and the time consumed is calculated in hours.

This speed of technological innovation, even Dalbeco, could not necessarily have been foreseen.

It should be said that Yang Rui tried to influence Dalbecco's decision based on past experience.

Dalbecco was also really affected.

If someone else said this, even Professor Cai, or even someone like Professor Richard from the University of California, Berkeley, Dalbecco would not be affected.

But Yang Rui is different. Yang Rui is the inventor of PCR, and Yang Rui is also the pioneer of genomics.

Dalbecco has been paying attention to Yang Rui's research from beginning to end. As far as scholars currently doing genetic research, there is no one who does not pay attention to Yang Rui's work. The name of the so-called shadow man of the tree, Yang Rui's performance in the past two years determines the value of his thoughts.

If Dalbecco had to choose who is most qualified to estimate the development speed of genetic technology, Yang Rui might not be the first choice, but if Dalbecco had to choose between himself and Yang Rui, he would trust Yang Rui more.

The so-called technical industry has a specialization. Dalbecco's research in the field of genetics, especially in the field of genetic technology, is far less in-depth than that of Yang Rui. Moreover, Dalbecco is no longer young.

A scholar's research life can last for a long time, but he has to rely on himself, especially rely on his own intelligence and physical strength to complete the research work, usually under the age of 40, at least under the age of 50.

This is the golden age for scholars. Scholars who are over 50 years old can be a competent academic leader, a competent laboratory manager, and a competent project manager, but they are not suitable for veto The academic output of scholars who are at the peak of their energy, body and intellect.

"Do you think it will take a few years for us to catch up with the results of parallel technology by adopting technology-first methods?" Dalbeco already has a tendency in his heart.

"Three years. If the sequencing starts in the third year, by the end of the third year, it will not be a problem to complete the sequencing of one million base pairs. If the sequencing is not carried out in the third year, it will start in the first half of the fourth year. 10,000-level sequencing." Yang Rui is very confident about this. The Human Genome Project is a very large project, which means that it is a project with a lot of personnel and funds. As long as you choose the right direction, the results will be produced very quickly.

"Your prediction has a basis, right?"

"certainly."

Dalbecco thought for a long time, and admitted: "If you can really achieve a sequencing speed of tens of millions, your plan may really be better."

He raised his head and said, "Would you like to write an article on this?"

"No problem." Yang Rui has been training for so long, and it is easy to write an article. As for the evidence, it is the fact that it is not difficult to prove it.

"Our Peking University fully cooperates." Professor Cai timely turned it into a cooperative project.

Yang Rui said indifferently: "Then use the ion channel laboratory to do it."

Professor Cai nodded and said, "I agree."

Of course Dalbecco didn't care anymore, after confirming the matter, he asked more actively.

In his mind, there was also a thought that was getting tighter and tighter.