Shenhao: Gold Medal Investor

There are several people sitting on the sofa in the living room.

Professor Zhuang Tao sat in the middle, with his wife Fan Jing next to him. Graduate students Wu Jun and Xu Rongcai, who were sent by Gao Si for further study, sat neatly at the bottom of the sofa. There was a pocket projector on the coffee table, and the picture was projected.

Go to the curtain opposite the sofa.

Zhuang Zuqin opened the door and everyone stopped talking.

Zhuang Tao stretched out his hand and said, "Gao Si is here, come on, come and sit."

The professor's expression was relatively relaxed, which made Gao Si feel more at ease. He hoped that this time it was just a chat, and he would not throw any national-level bounty tasks to him.

Zhuang Tao got straight to the point and said: "Wu Jun, please introduce the current situation. There are some things that Gao Si and Xiaoqin may not be clear about."

Wu Jun was a little flattered. He glanced at Professor Zhuang and said after receiving the encouraging look: "In the past two months, with the physical and chemical data of the compounds provided by Professor Fan, the accuracy of predictions has improved very quickly. Fan

The professor said that the predicted data now has application value."

Gao Si asked: "Professor Fan, didn't you build a new team in the Department of Materials?"

Fan Jing looked at Wu Jun and Xu Rongcai with a smile, her eyes full of love: "Doing this requires a deep foundation in mathematics. Among my students, I can't find anyone as suitable as the two of them for the time being, so I can only let them

Both of them are co-authors. I said that after they finish their master's degrees and take Ph.D. examinations in the Department of Materials Science... Lao and Zhuang will not agree."

Gao Si was delighted. Unexpectedly, the two nerds, Lao San and Lao Wu, turned out to be good students that two well-known scientists were competing for. Gao Si couldn't help but feel a little proud. Sure enough, as long as they find the right soil, every seed will bloom.

.

Professor Zhuang Tao had a smile on his face. He said: "Mathematics is the foundation of all sciences. This is determined by the nature of modern science. I have never objected to my students focusing on applied fields. But I do not agree with them.

Treat materials science as a major. Wu Jun, please continue."

Wu Jun continued: "Since last month, the seniors in the Materials Department have begun to accumulate materials databases. They are responsible for finding popular applications, and then we make evolutionary predictions based on popular applications."

He was afraid that Gao Si wouldn't understand, so he explained: "Evolutionary prediction is just like the evolution of life, making slight modifications to the description of the material structure, and then re-predicting the properties of the material. The final thing is a bit like

It is an evolutionary tree describing the evolution of life.”

A picture similar to an evolutionary tree is projected on the screen. Click on a node to expand many types of materials evolved from this node.

Gao Si felt that the hairs on his hair were exploding for a moment. His eyes widened and he said, "This is too powerful. For example, let's take a medicine that already exists. Through this kind of deduction, we may be able to achieve an effect."

There’s a new drug that’s better than that!”

There were messy black lines in Fan Jing's smile. She shook her head and said with a smile: "Gao Si, it would be great if you could use your little cleverness in the right place."

Fan Jing cannot deny that the pharmaceutical industry is indeed one of the fastest ways to monetize this project. First find an expensive and easy-to-use drug, and then deduce it from its molecular structure, and deduce all substances with similar molecular structures.

.If there is a similar substance that may have better medicinal effects, you can conduct animal experiments. If it is successful, you can proceed to clinical trials.

This is a low-level innovation in the drug research and development process. The purpose is to bypass the patent protection of existing drugs, and the drug efficacy is equivalent to that of similar breakthrough patented drugs. Because it saves high research and development costs, this kind of

So-called new drugs are often more profitable than first-of-its-kind drugs. These drugs are called me-too drugs in the industry.

Gao Si scratched his head and giggled. Of course he knew what his wife meant. However, as an investor, the matter of finding bargains had penetrated into Gao Si's bones. He had never thought about it before, but after thinking about it, he must have thought about it.

Won't let it go.

Gao Si asked: "Professor Fan, has our project been successful in applying for a national key scientific research project?"

He asked this out of selfishness.

In the past, he had never worried about the source of funds. He was in a state where he could spend it as he pleased. Of course, he didn't care too much about who would own the new materials after research. He would bypass other people's patents and launch his own so-called 'new medicine'.

This was something Gao Si never bothered to do before.

But it's different now. Gao Si can't make money from the stock market or spinach anymore, so getting a few me-too drugs to make money has become a problem that Gao Si should seriously consider.

Gao Si doesn't really want to enter the pharmaceutical industry, but finding a similar chemical structure and selling it on the shelves after clinical trials is a very profitable business.

Fan Jing smiled and replied: "Do you want to hear the good news or the bad news first?"

"You must hear the good news first."

"The good news is that the application for the national key scientific research project has been submitted, and the possibility of being selected is not small. In addition, this project has received 14 million yuan in scientific research funding this year. When the first funding is received, the super debt owed to you can be paid.

That’s part of the cost.”

Fan Jing glanced at Zhuang Zuqin. It seemed that Zhuang Zuqin had been collecting debts at home during this period.

Gao Si smiled and said: "What about the bad news?"

Professor Zhuang Tao answered: "It's not bad news. Wu Jun, please introduce me to Gao Si."

Wu Jundao: "The bad news is that even if we know the molecular structure and properties of many substances, we don't know how to produce them. Even if we create a complete database so that we can easily find suitable materials, we may still face difficulties.

Production problems.”

"The most typical example is graphene. We know that the structure of graphene is very stable, we know that its thermal conductivity is very good, and we also know that graphene has good light transmittance, toughness and biocompatibility. But we just can't make it.

Produce large pieces of single-layer graphene."

Gao Si immediately retorted: "You don't want to predict the production process of chemical substances. However, the reason why we cannot make graphene is that we lack the necessary physical methods. There is no way to predict it. Who can predict the use of transparent materials?

Tape separates graphene."

Wu Jundao: "My example is not good, let me change it. Just last week, we found a substance in the prediction results that can disrupt the formation of peptidoglycan from several different sites."

Gao Si looked confused. He was wondering if you could speak human words well.

Wu Jun quickly explained: "Peptidoglycan is the main component of the bacterial cell wall. This means that it can kill bacteria and can be used to make antibiotics. However, it is useless to know that it can make antibiotics because its molecular structure is too strange.

No one knows how to make it."

This time Gao Si understood. Knowing it but not being able to create it is worse than not knowing. However, theoretically speaking, the manufacturing path of a chemical substance should also be predictable. However, Gao Si does not have it now.

The ability to solve such problems.

Gao Si remained silent.

Zhuang Tao smiled and took out a brown paper bag, and Gao Si could only pick it up with both hands.

Zhuang Tao smiled and said: "Your master's wife's side is closer to the application and has always been richer than the mathematics department. No, they have issued a national reward. I think Wu Jun, Xu Rongcai and you should all take a look. If

If we can find a mathematical model for this problem, then the national key scientific research project will be almost certain."

Seeing Gao Si's expression of embarrassment, Zhuang Tao said again: "Don't be afraid of difficulties. Wasn't it you who took the lead in solving the first national bounty project? Although you didn't take the postgraduate entrance examination and may be unfamiliar with your major, I believe in your ability.

.The more you use your brain, the better it becomes."

Gao Si nodded, but still did not open the brown paper bag.

Zhuang Tao added: "You can't refuse, this is a task assigned to you by the country!"