Siheyuan: Started in 1952, full-level medical skills

Chapter 20

Jia Zhang's old goods wandered around the penicillin factory and the small courtyard of the silk shop all day.

In order to get to know a few young and beautiful girls, choose the best one to be their daughter-in-law.

Take advantage of the end of the day.

Jia Zhangshi, a kung fu who was out shopping, stopped a girl who looked like Zhou Zheng to ask about the penicillin factory.

Girls are also simple.

Pouring beans generally tells the whole story.

Jia Zhang's heart was unbalanced.

Not yet a regular worker.

A monthly salary of about 200,000?

His son Jia Dongxu is exhausted in the machinery factory, how much salary is only in January!

Especially.

When she heard that Qin Huairu, who was abandoned by the Jia family, was actually one of the few formal workers in the penicillin factory, and she was still in charge of so many female workers.

I almost didn't get angry.

I have no intention of talking to girls anymore.

Returning to Jia's house in a huff, he scolded Qin Huairu for not being a thing.

Bacheng got into Xu Cheng's bed.

Otherwise.

Just by her?

Can you be the leader?

Jia Dongxu said in a low voice: "Now Xu Cheng is one of the shareholders of our machinery factory, can you stop talking nonsense, in case it reaches his ears, and then fire me, if that's the case, our family will be caught blind!" "

"I . . ." Jia Zhangshi was angry and speechless, and scolded: "Useless things, this is in our own home, let me tell me what's wrong, what are you afraid of?" "

Lao Jia sighed and shook his head.

Push your wheelchair and walk outside.

One of his legs was sawn and he could only be used as a wheelchair.

After working hard for most of his life, Lao Jia felt that he could not lose himself, so he specially bought a wheelchair imported from the Soviet Union.

Rubber wheels, about the same price as a bicycle.

Jia Zhang hurriedly helped her husband cross the threshold and asked, "Old Jia, you are..." "

"I'm out for a spin!" Lao Jia opened his mouth and said, "Looking at you two talking about each other, I'm very annoyed!" "

Lao Jia went out on the street alone.

He pushed the wheel while observing the movements of the people around him, trying to find out which person was a spy.

If you find a little clue, you can not only avenge the revenge of being implicated by the secret agents, but also make great achievements.

After turning around for half a day, I didn't find anything.

He went to the Pok Oi Clinic to check his health.

There is a walk on the line of life and death.

Lao Jia no longer dared not pay attention to his health, and often went to the Boai Clinic to ask Yan'e to help check his body to prevent that damn sepsis from continuing to attack.

Comes and goes.

I actually mixed with Yan'e.

Yan'e secretly spat and thought in her heart: "You are an old and unorthodox person, let me a woman examine the root of your thighs, okay, don't face!" "

Yan'e is in her early thirties, although she is not as shy as the little girl, she is still quite taboo about this kind of thing, and casually glanced at it and said: "The wound is fine, there is no sign of inflammation!" "

Lao Jia scolded: "What a special dog spy, even tired of labor and management, one day I want you to look good, I found a report one!" "

Yan'e was annoyed.

She's a spy.

Lao Jia, didn't he scold the bald donkey in front of the monk?

I thought to myself, "If I hadn't been afraid of exposure, I would have brought you crippled a long time ago!" "

Penicillin G production can be divided into two steps: strain fermentation and extraction and refining.

Strain fermentation: Penicillium flavinogenum is inoculated on solid medium and incubated at 25 °C for 7~10 days to obtain Penicillium spore culture.

Inoculate the spores into a sterilized medium inside the seed jar by making a suspension with sterile water.

Sterile air was introduced, stirred, and incubated at 27 °C for 24~28h.

The seed culture medium is then inoculated into a sterilized medium containing phenylacetic acid precursors in the fermenter, passed into sterile air, stirred, and incubated at 27 °C for 7 days.

During the fermentation process, phenylacetic acid precursors and an appropriate amount of medium need to be added.

Extraction and refining: the penicillin fermentation broth is cooled and filtered.

Under the condition of pH2~2.5, the filtrate was extracted with butyl acetate in the extractor for multi-stage countercurrent extraction to obtain butyl ester extract.

It is transferred to a buffer of pH 7.0~7.2, and then transferred to butyl ester, and the butyl ester extract is decolorized by activated carbon, added into a salt agent, and penicillin G potassium salt can be obtained by azeotropic distillation.

When the first batch of penicillin was produced, all the chemical reagents were completed by Xu Cheng alone.

In order to get pure penicillin G potassium salt.

Xu Cheng put a lot of effort into the extraction stage, not only staring at it personally, but also repeatedly extracting it many times.

I got the powder of medicine, bought a glass bottle, and then it was time to divide it.

Dispensing penicillin is not easy.

A bottle of 200,000 units of penicillin is only 0.12 grams.

Even if it is impure, it will not exceed 0.13 grams.

Same batch.

After trial and error, Xu Cheng determined the weight of 200,000 units of penicillin, and spent a lot of effort to find an analytical balance.

Xu Cheng asked the female workers to try to divide penicillin.

Outcome.

Several female workers tried and failed.

Only Qin Huairu learned the use of analytical balances.

Xu Cheng tirelessly taught for a long time.

The grinning Chen Xueru also learned.

Xu Cheng said: "This is not your job, you must teach the use of analytical balances to other female workers as soon as possible!" "

The two of them worked hard to teach.

Finally.

A girl named Xu Huizhen learned first, and she taught the method to her cousin Xu Huizhi.

When the fifth person learned to analyze the scale, Xu Cheng stopped them.

Five people are enough for packing.

And there are no more analytical balances.

Through trial and error.

Xu Cheng believes that the purity of penicillin is up to standard.

This era.

Even the penicillin produced in the United States and the Soviet Union is not pure, and it is not much stronger than the products of the penicillin factory.

Impure penicillin can cause allergic reactions.

When the drug was in clinical trials in the fifth hospital, Xu Cheng insisted that doctors do skin tests.

The dean did not consider it necessary.

Even in the case of allergies, the rate of shock and mortality is low.

Especially the mortality rate.

There is only one death case per 100,000 to 100,000 allergy sufferers.

Is it necessary to do a skin test?

So troublesome.

Even.

The dean was still a little unimpressed in his heart.

What if I do a skin test?

Have surgery, especially major surgery, been done without penicillin?