Siheyuan: Started in 1952, full-level medical skills

"Xueru . . ." Xu Cheng pulled Chen Xueru into the room and said, "I have nothing to do with her!" "

He just wanted to explain again, but Chen Xueru said: "I know, in fact, I have already come over, I saw what happened just now in the crack of the door, and I heard what you said!" "

Chen Xueru was very pleased.

met such a shameless woman as Zhou Qiuyue.

If you shake a little, you may sink.

But the husband didn't.

He withstood the graduate school exam.

Chen Xueru didn't want to continue this embarrassing question, and asked casually: "Brother Xu, what kind of disease is she, why can't she seem to have children?" "

"How do I know!" Xu Cheng said deliberately: "How about I take a closer look at her the next time I see her and take her pulse?" "

Taking the pulse does not find the real cause of the disease.

He gave Zhou Chunhua a pulse, and he could only diagnose weakness and coldness.

"Nope!" Chen Xueru immediately said: "Brother Xu, let's stay away from the sisters of the Zhou family, I don't think they are good people!" "

Xu Cheng nodded solemnly and said, "I know.... "

Chen Xueru suddenly realized that her husband might be teasing her just now.

He would definitely not contact the Zhou family sisters.

Xu Cheng sat down again at the desk and began to write about the gentamicin manufacturing process, process, and related biochemical reactions.

Chen Xueru asked with interest, "What are you doing?" "

"I thought of the next drug that could be prepared by the pharmaceutical factory, and when I figured out all the production process, we started manufacturing equipment to produce drugs!" Xu Cheng said.

"Really?" Chen Xueru said with some excitement: "When will we be able to mass-produce this drug?" "

What Xu Cheng wants to make must be a new drug.

Just like penicillin, there are no manufacturers in the country, and then you can make a lot of money again.

Xu Cheng said: "How can it be so fast? It must be prepared in the laboratory first! "

The production of gentamicin sulfate is based on Micromonosporus crimson No. 2 as the gentamicin production strain, which is continuously cultured and fermented in a steam sterilized medium, and gentamicin with bacteriostatic activity is secreted through the secondary metabolism of the strain.

The active substances secreted by bacteria were extracted from ion exchange resin, and gentamicin sulfate API was produced by refining and salt transfer.

Gentamicin is demanding on the production environment and has a lot of steps.

Xu Cheng needs to simulate in the laboratory first, obtain the original gentamicin drug with higher purity and then produce it, and use equipment to restore the test steps and environment as much as possible.

"This way!" Chen Xueru said excitedly: "Or let's go to the laboratory now, I'll help you!" "

Speaking of developing new drugs.

Chen Xueru is very positive.

"Okay!" Xu Cheng said: "You and I go over, when the laboratory results come out, we will start to produce new drugs!" "

Lock the door.

Xu Cheng rode his bicycle with Chen Xueru and left.

Waited until the laboratory courtyard.

Xu Cheng began to direct Chen Xueru to conduct experiments to prepare penicillin.

Laboratory preparation of gentamicin sulfate consists of the following steps: fermentation, extraction, refining, sterile compressed air, sterile spray drying.

Xu Cheng prepared the medium with the help of Chen Xueru, put it into a 500ml shaker flask, filled 50ml, sterilized with 1kg/cm2 saturated steam at 120 °C for 30 minutes, and cooled for later use

On the ultra-clean bench, under the protection of flame, use a steam-sterilized sterile inoculation shovel to dig 0.5cm2 of beveled spores into a seed bottle, put them on a shaker, and incubate at 35°C±0.5°C for about 40 hours.

After placing the spores in the seed bottle.

Xu Cheng said: "Wait slowly, it will take forty hours!" "

"Forty hours!" Chen Xueru asked, "Let's wait in the laboratory?" "

"Nope!" Xu Cheng said: "Just put the seed bottle in a suitable environment, and I will come back to deal with it the day after tomorrow!" "

"So now..." Chen Xueru asked.

"Go home!" Xu Cheng said: "Even if we wait here, it won't help!" "

Chen Xueru nodded in agreement.

When the two returned to the courtyard, it was already dark.

Backyard.

Xu Fugui fought with Xu again.

The two sons and daughters cried to the heavens.

When Xu Cheng and his wife passed by, they did not find other neighbors coming to persuade.

They also did not pass.

When I got home, I unlocked and went into the house.

Chen Xueru asked, "Brother Xu, do you say that this gentamicin can be more expensive than penicillin?" "

"Gentamicin has a wider antibacterial spectrum than penicillin, the same 200,000 to 250,000 units, it should be a little more expensive than penicillin!" Xu Cheng said: "The cost should also be a little larger than penicillin, but it will not exceed too much!" "

In fact.

If the pharmaceutical company produces gentamicin, it is the only one, and the price is of course up to them.

If the price is compared with foreign sulfonamides, the price is amazing!

"So you won't make less money than penicillin?" Chen Xueru was happy.

Late at night.

She thought that the pharmaceutical company should be able to make another profit.

Smiling.

Lying in Xu Cheng's arms, he pillowed her arm and entered the dream.

After the seed bottle had been cultivated for forty hours, Chen Xueru was clamoring to go to the laboratory with Xu Cheng.

Transfer the medium into the fermenter for fermentation.

Ninety-six hours later, the extraction is carried out and other operations are carried out.

Finally, gentamicin stock solution was obtained, and then gentamicin sulfate was made.

Divided packages.

Although it was prepared in the laboratory, fifty or sixty bottles of 200,000 units of gentamicin sulfate were also obtained.

"Is that all set?" Chen Xueru said.

"After laboratory tests determine that its properties are stable, it can be used in clinical trials, and if the test results are satisfactory, it can be mass-produced and sold!" Xu Cheng said.

When he went to work at the Fifth Hospital, he told the dean about the gentamicin he had prepared in the laboratory.

The dean was thrilled to hear that gentamicin has a wide antibacterial spectrum, especially for gram-negative bacteria.

So to speak.

If gentamicin and penicillin are used together, won't it have an inhibitory effect on almost all bacteria at present?

"Xu Cheng!" The dean said: "Find a suitable opportunity to conduct clinical trials, and once the efficacy is determined, put into production and use as soon as possible!" "

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