Start as an Emergency Physician

Previous antidepressant drugs have a similar mechanism of action, which is to control the condition by regulating hormones in the body, but ketamine obviously has nothing to do with hormones in the body.

In addition to being the main ingredient of poisons, ketamine is mostly used as an anesthetic for minor surgery or diagnostic operations in clinical practice, in other words, it can block the excitability of the body.

Zhou Yuan immediately became nervous.

Where does ketamine act on the brain, on which cells, and why does it have a rapid antidepressant effect?!

At present, the treatment of depression in the world is very slow, taking weeks or even months, but only about 20 to 30 percent of patients are effective.

This also means that today's antidepressant drugs may only work indirectly, and the human understanding of the mechanism of depression is not clear and does not touch the core.

At this time, ketamine suddenly appeared in Zhou Yuan's sight, and it took effect in an hour, and it had a therapeutic effect on seventy or eighty percent of patients!

Zhou Yuan realized that this could be the key to further human understanding and treatment of depression...

The stimulant took effect, and Zhou Yuan's brain began to run at full speed.

When it was close to one o'clock in the morning, Zhou Yuan suddenly raised his head, and his eyes lit up.

He immediately dialed Sun Meng's phone, and she was still working in the hospital at this time, "Sun Meng, can the laboratory given to me by the hospital be activated before?"

Sun Meng was a little confused, "Can it be enabled, do you want to carry out the project?"

She was on duty, and she was a little happy to receive Zhou Yuan's call, but she didn't expect Zhou Yuan to ask about the situation in the laboratory.

"Yes, I'm going to start the trial right now, you can help me apply to the hospital. "

Sun Meng was a little surprised.

When she was hospitalized, she was indeed responsible for these bits and pieces.

"Understood, is the plan written, how much money is needed, and how long is it expected to be researched..."

Before Sun Meng finished asking, Zhou Yuan was stunned.

Still want to write a proposal?

Seeing that Zhou Yuan was silent, Sun Meng guessed it and said, "What research are you going to do, I'll tell the hospital directly... You can be treated with special treatment, even if you don't have a plan. "

Zhou Yuan is the person who Dean Fang promised to provide unconditional scientific research funds, and he wants to carry out research, but no one in Yanjing Traditional Chinese Medicine can stop him.

Zhou Yuan: "It is related to nerve discharge, and the main research direction... Lateral reins. "

"Outer reins?"

Sun Meng was stunned for a moment.

The nucleus is very conservative from the lower animals, plays an important role in regulating circadian rhythms, and is also able to dictate the choice of action based on the horrors of the past.

For example, when a predator or a crisis suddenly strikes, to run away or to stand still, this command and choice depends on the deadlock.

If the zombie nucleus is lost, the animal loses the escape behavior that gives the experience of terror, and although it is frightened, it will not run away, and will wait for death.

And the important reason that made Sun Meng stunned was that the outer reins were under the hippocampus!

In other words, the lateral nucleus is related to the depression that Zhou Yuan is studying. It is the brain's counter-reward center, which mediates most of the brain's negative emotions, including fear, nervousness, anxiety, etc., and antagonizes the monoamine nucleus called the reward center in the midbrain.

To put it simply, the lateral reins are based on the external environment to produce negative emotions such as fear and nervousness, while the reward center of the midbrain is to feedback positive emotions such as happiness and relaxation.

It is not a secret that Zhou Yuan studies depression, and people who have more contact with Zhou Yuan in the hospital know that he proposed to study the lateral nucleus at this time, and the purpose is self-evident.

Sun Meng nodded: "Understood, I'll apply immediately, when do you plan to start?"

"Tomorrow!"

After hanging up the phone, Zhou Yuan immediately began the design of the experiment.

Although he had the entire process of the experiment in his head, it took too long to complete the experiment, and Zhou Yuan did not have so much time to spend on it, so he could only participate in the most critical part.

Now that you are part of the national lung transplant program, you need to make good use of it.

In addition to lung transplant talents, there are many scholars on Zhan Ting's side who specialize in experiments, and Zhou Yuan hopes to hand over this experiment to them.

The purpose of the experiment is simple, to explore the principle of ketamine antidepressant.

In a previous five-hour study, Zhou Yuan sensed that ketamine was likely to affect the activity of the lateral nucleus.

Depression is very closely related to the lateral reins, and the negative emotions manifested by depression are related to the feedback from the lateral nucleus.

As we all know, neurons send messages downstream through electrical discharges, and the lateral nucleus must also need to be discharged if they want to transmit messages out of the brain, thereby causing various emotions.

So...... Is there a difference between a depression-inducing discharge and a normal negative emotional discharge?

Zhou Yuan devised two experiments to determine whether mice were depressed, forced to swim and sugar water preference.

When mice fall into a pool, normal mice will show an active struggle to survive, while depressed mice will show behavioral despair, giving up the struggle at the moment of falling into the pool and entering a suspended state.

Another sugar water preference experiment is based on the mouse's preference for sugar water. Depressed mice lose interest in sugar water, which manifests a lack of anhedonia in animals.

Then, the discharge mode of the lateral brucus of the two groups of mice was detected, and the discharge of depressed mice was simulated to normal mice to observe whether the normal mice would become depressed!

Early the next morning, Zhan Ting received news from Zhou Yuan, and after a brief surprise, he immediately contacted the team members who were in Yanjing and rushed to Yanjing Traditional Chinese Medicine to assist Zhou Yuan in his research.

After Zhou Yuan sent the experimental plan to the team members, he squinted for about half an hour, drank three more bottles of energy medicine, and prepared to go to work.

As for why you sleep for half an hour ...

Because after the stimulant lost its effect, Zhou Yuan suddenly felt that he had become an idiot, and he had to rely on sleep to buffer this emotion, otherwise Zhou Yuan would spend the whole day in this shadow.

After taking the stimulant, Zhou Yuan found out that the stimulant actually has side effects.

For example, the mental consumption is too amazing, usually Zhou Yuan only needs one bottle of energy potion to recover his state, but this time he used up three bottles.

Moreover, Zhou Yuan's ears are very hot now, his mental function is unbalanced, and his emotions are a little unstable. These are all manifestations of overuse of the brain.

But these are just minor problems, nothing compared to those stimulant drugs, and you can recover after a while.

Stimulants are also considered to be systematically produced, and they are the only items with mild side effects. _

Feilu reminds you: there are three things to read - collection, recommendation, and points