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Yuan nodded:"It can reduce the graft-versus-host reaction and reduce the incidence of postoperative complications to a certain extent."

The doctors in the hematology and oncology departments looked at each other.

"Blood cell separator." Zhou Yuan said.

Zhou Yuan carefully moved the bone marrow into the blood cell separator and washed the bone marrow cells.

After a while, the bone marrow and blood cells were separated after centrifugation. Zhou Yuan took out the bone marrow and transferred the blood cells back to Liu Huimin's body.

"This is……"

Zhou Yuan took out a new disposable needle, paused, and explained:"The donor's blood type is A, and the patient's blood type is AB. Although A blood can be transferred to AB blood, the bone marrow blood now contains heparin NS, and the donor's plasma has antibodies that agglutinate the patient's red blood cells.……"

"Once the antibody titer is greater than one in two hundred and fifty-six, the patient's immune system has been damaged and there is no way to resist the attack of the antibody, which will cause the patient's red blood cells to be damaged, thereby aggravating the graft-versus-host reaction."

He Jianyi and others were all stunned.

Zhou Yuan didn't say much and said,"Filter the bone marrow blood according to what I did just now."

"Two intravenous channels are established, one for infusion, and the infusion ratio is 2.5 to 3 times the amount of bone marrow blood extracted. The other channel delivers autologous blood to maintain the donor's blood volume and blood pressure. The needles of both intravenous channels must be above 19 gauge."

He Jianyi immediately opened the intravenous channel.

Before the operation, the hematologist had collected Liu Huimin's blood and blood components, preparing to transplant them back into her body after peripheral blood stem cell transplantation to reduce postoperative pain and sequelae.

At this time, it is just right for maintaining blood pressure during bone marrow transplantation.

Seeing that the intravenous channel was opened, Zhou Yuan picked up the needle that had been drawn with heparin NS again, inserted the needle along the hole of the previous bone puncture, and extracted bone marrow again.

Only 7.5 ml of bone marrow blood can be extracted each time, and the final amount is about 800 ml.

However, what the patient actually needs is only the hematopoietic stem cells in the bone marrow blood, so there are actually not many hematopoietic stem cells extracted from these 800 ml of bone marrow blood.

This is why it is necessary to accurately Prepare 200 disposable syringes.

In addition to the cumbersome process, bone marrow extraction also takes a lot of time.

Zhou Yuan extracted very slowly in order to cause as little discomfort to the donor as possible. According to regulations, it takes at least thirty minutes to extract every 500 milliliters of bone marrow blood.

Zhou Yuan extracted bone marrow blood one by one, while the hematologists and oncologists carefully filtered, separated, counted, and stored the blood cells.

The demand for hematopoietic stem cells for allogeneic transplants is 2 to 6x10 (eighth power)/kg, and for autologous bone marrow transplants is 0.5 to 5x10 (eighth power)/kg.

The transplant between Liu Huimin and her daughter was an allogeneic transplant, so a greater number of hematopoietic stem cells were needed.

After about two hours, the bone marrow was completed.

"The operation is complete."Zhou Yuan breathed a sigh of relief.

Liu Huimin's vital signs were stable, and the transplant was much smoother than he had imagined.

After the operation, Liu Huimin's side effects would be reduced a lot.

The doctors in the hematology and oncology departments were silent.

The results of the bone marrow extraction had already explained everything. Zhou Yuan's bone marrow transplantation technology was far superior to the two of them...

Otherwise, this bone marrow extraction would not have been so smooth.

""Doctor Zhou, please send the stem cell suspension over... We will continue processing." said the hematologist.

Zhou Yuan nodded and did not refuse. He took the processed stem cell suspension to the transplant cabin.

A few minutes later, Zhou Yuan and He Jianyi arrived outside the transplant cabin.

Inside the transplant cabin, Haoyue's face was swollen, and his hands and feet were obviously swollen. His complexion was also very ugly, much worse than Liu Huimin's.

Continuous chemotherapy brought a series of adverse reactions, such as nausea, vomiting, etc., which was very torturous, but in order to survive, Haoyue had to endure it.

""Has the hematopoietic stem cell suspension arrived?" The nurse came over in a hurry.

Zhou Yuan nodded and handed the suspension to the nurse.

Bone marrow transfusion is different from other surgeries and does not require surgery.

The process is like an infusion. After the doctor delivers the stem cell suspension, he hands it to the nurse, who then delivers it to the transplant chamber and delivers it into the patient's blood by intravenous drip.

Just as the nurse was about to put the stem cell suspension on the infusion stand, Zhou Yuan stopped the nurse.

"Wait, add a 0.2 mm mesh filter when inputting."

The nurse was stunned:"Why?"

"Prevent fat embolism.

This is also to increase the survival rate of hematopoietic stem cells after they enter Haoyue's body.

The nurse nodded.

"One more thing, the last 10ml of each bag of bone marrow blood should be left in the infusion tube and discarded, and not be injected into the patient's body."

Zhou Yuan didn't need to explain too much to the nurse.

With the current level of technology, many substances in the blood cannot be separated.

Hematopoietic stem cells should theoretically be evenly distributed in the stem cell suspension, but some other substances, due to different masses, will accumulate in the last part of the suspension. The

10ml of bone marrow blood has no effect on Haoyue, but it can remove substances that are not conducive to bone marrow transplantation.

The nurse nodded,"I've made a note of it."

After doing all this, Zhou Yuan breathed a sigh of relief.

However, it does not mean that the bone marrow transplant was successful.

Once the bone marrow transplant is completed, the patient is likely to develop a series of postoperative complications. Early complications include bone marrow failure and pancytopenia, accompanied by various infections, bleeding, etc.

However, the infection step should be avoidable because of Zhou Yuan's precise operation.

Late complications are mainly chronic graft-versus-host reaction, immunodeficiency, pulmonary complications, infertility, etc.

These can only depend on the combination of hematopoietic stem cells in Liu Huimin's body and the patient. Even if Zhou Yuan has a perfect bone marrow transplant, he can't do anything.

The three days after the operation are the peak period. During this period, various early complications may come to the door. Three months after surgery is a dangerous period. If you get through the first three days, there is still a chance of complications during these three months, but the risk is much smaller.

One year after surgery, if there is no recurrence, basically this bone marrow transplant has been successful, and there will be no problems under normal circumstances.

Zhou Yuan sighed helplessly.

This operation should have dragged down the Haoyue family...

Leukemia is difficult to treat. Not only is it difficult to find a bone marrow match, but various complications will take the patient's life. Another point is the high cost.

A bone marrow transplant operation costs at least 300,000 for the initial treatment alone, plus the later care and medication. If there is another complication, it will easily cost millions. _To read the ununderlined version of the novel, please download Fulu Novel AP