The Godfather of Surgery

It takes 6-8 hours for a virus to replicate a generation through division, which is an amazing speed.

About one billion viruses piled together are about the size of a grain of rice. With one virus as the origin seed for exponential division, it takes 30 replications to reach about 1 billion. 30 divisions take about 150 hours, which is about 6 days.

The speed of virus division is so fast, so it determines that its risk is also very high.

If all the split viruses do not mutate, or the changes after mutation are not big, and do not deviate from our expectations, there is generally no problem. Because the consequences caused by these viruses are already within the experimenter's expectations and control, and the viruses used by the experimenter are also strictly selected, and will not cause obvious harm to the human body. For example, the measles virus and vesicular stomatitis virus have little negative impact on the human body, and they are transient.

The most terrifying thing is that the virus has unexpected and uncontrolled mutations during the iteration process. Once the virus has such mutations, its harm will exceed our expectations and control. These mutated viruses can still divide exponentially, and the number is increasing.

If these new viruses have some kind of pathogenicity, once they enter the human body, there is no effective drug to eliminate them, or the human immune system cannot eliminate them, which is tantamount to infecting patients with a new viral disease. Of course, the probability of such a risk event is extremely low.

Virus cultivation experiments must be carried out in a biosafety level 3 laboratory, so Lu Xiaolu needs to conduct virus experiments in the high-level biosafety laboratory of Nandu Medical University. At present, the stem cell laboratory and tumor laboratory of the Institute of Surgery do not have such conditions. These two laboratories are not prepared for virus experiments.

When Lu Xiaolu was studying in Germany, he had a lot of contact with these multidisciplinary cross-fields, so he was familiar with immunological treatment, biological treatment, targeted treatment, and oncolytic virus therapy for tumors. This experiment is most suitable for him to do.

The professors of the virus laboratory at Nandu Medical University are very happy to cooperate with Sanbo Hospital, so they quickly reached a cooperation intention, and a Nobel Prize-winning virologist introduced by Professor Brian will soon start cooperation and exchanges with Lu Xiaolu.

Yang Ping and Lu Xiaolu went to Nandu Medical University to inspect the virus laboratory and talked with Professor Zhang Zhiwei, the director of the virus laboratory, for a long time. After the conversation, Yang Ping and Lu Xiaolu decided to walk around the campus of Nandu Medical University. It was rare for him to come here, but whenever he could spare time, Yang Ping would walk around.

On a tree-lined avenue, Yang Ping saw President Rao from a distance. He came to the school to handle the procedures for early retirement.

President Rao resigned because of the incident between Guan Ruyan and President Ding. Professor Su Qingyun, the dean of Nandu First Affiliated Hospital, succeeded President Rao as the new president of Nandu Medical University and concurrently served as the dean of Nandu First Affiliated Hospital.

In fact, President Rao is indeed a good president. He is honest and upright, daring to act, and has a righteous scholarly demeanor. During his tenure, he made great contributions to the development of Nandu Medical University and implemented many very meaningful reforms. He also provided a lot of help to Yang Ping at that time.

When President Rao resigned, Dean Xia, Professor Su, Yang Ping and others invited President Rao to dinner and held a farewell ceremony for him.

From a distance, Yang Ping saw Professor Su and several vice presidents talking to President Rao. A large group of students surrounded them. In fact, these students were reluctant to leave President Rao. When they heard that President Rao was back to handle the formalities, they spontaneously gathered around to shake hands with President Rao.

Principal Rao also saw Yang Ping. The two of them stretched out their hands from a distance, and then walked over to shake hands.

"Professor Yang, how are you doing recently? I heard that you are doing a virus treatment experiment on tumors recently. Professor Zhang Zhiwei in our school's virus laboratory is very good. He has worked in several top virus laboratories in the United States, Britain and Germany before, and his academic achievements are remarkable." President Rao was in good spirits and obviously did not have the retirement syndrome of leading cadres.

"Yes, we came here to talk to Professor Zhang about the cooperation of the project. How are you now?" Yang Ping was also very concerned about the recent situation of President Rao.

"As for me, I am retiring and returning to my hometown. Not long ago, I went back to my hometown to worship my ancestors. The local government heard that I had retired and hoped to invite me back to be a government advisor to do education. For this matter, the county magistrate of our hometown came here three times. I couldn't refuse, so I agreed to go back to help with education and make use of my remaining energy. It can be regarded as something to do after retirement." Principal Rao said with emotion.

It seems that Principal Rao is also a person who can't sit still.

"Professor Yang, have you met Professor Zhang Zhiwei?" Professor Su usually calls Yang Ping Xiao Yang at home, and now outside, he also calls him Professor Yang in a formal manner.

"We met and talked for a long time. We just visited the laboratory. I told Professor Lu that it was a rare trip, so I was going to walk around the campus." Yang Ping explained immediately.

More and more students gathered around, including many teachers. The whole road was crowded at both ends, and the atmosphere was even more lively than when a star appeared. Yang Ping looked around and saw that there were thousands of people, and the number of people was still increasing. They had spontaneously stood on both sides of the road, leaving the middle.

"Principal Rao, we miss you so much!"

I don't know who took the lead and shouted.

"Principal Rao, we miss you so much!" The shouts of the entire crowd sounded like waves, one after another, and finally turned into a uniform shout.

Since resigning, President Rao has been on vacation. Today, he officially came to handle the procedures for early retirement. Unexpectedly, he appeared on the campus of Nandu Medical University for less than two hours and attracted so many people.

President Rao was a little overwhelmed at first, and then his eyes turned red. He immediately took out a tissue and gently pressed it against his eyes, then waved to everyone.

"I miss you too!" President Rao kept waving.

There was no room for people on this road, and the woods on both sides were also full of people. They all gathered temporarily after hearing the news. There was no organization, no banners, no flowers, only sincere shouts.

President Rao shook hands with the students and teachers who stretched out their hands, but he couldn't shake them at all.

A black car drove in, and Professor Su said, "The car is here."

"Professor Su, look, it's so troublesome for you to arrange a car. I can just take a taxi myself." President Rao said while waving to the crowd.

Professor Su opened the car door: "It's no trouble, let the car of Nandu Medical University take you again."

"Goodbye, President Rao, you must come back often."

Principal Rao looked back and saw the waving crowd, and reluctantly got into the car.

——

Sisi's transient dizziness became more and more frequent, and the symptoms became more and more obvious. Sometimes when the dizziness was severe, there would be a short-term loss of consciousness, but this short-term loss of consciousness generally did not last very long, only a few seconds.

Yang Ping knew that her dizziness was caused by an intracranial tumor. At this time, the intracranial tumor had affected the heartbeat center, causing a short-term inhibition of the heartbeat. After the heartbeat was inhibited, the blood output would be reduced or stopped, which would lead to insufficient blood supply to the brain. Dizziness is a reaction to insufficient blood supply to the brain. If this heartbeat inhibition continues to worsen, one day the brain will die due to long-term lack of blood supply.

Even if Yang Ping did not tell Sisi about her condition, the smart girl knew that it was the last moment, because Yang Ping had not told her about her condition and the next treatment plan, which meant that there was no plan now. She was also mentally prepared and faced it all calmly.

These days, every time Yang Ping made rounds, he would talk to her about the cactus pot and discuss with her the experience of cultivating desert succulents. Yang Ping never talked about the condition, and Sisi didn't ask. They had a very pleasant chat about the cactus.

The doctors, nurses and students who followed the rounds in the morning didn't understand why Professor Yang didn't talk about the condition during the rounds, but only talked about the cactus.

Every time he went to the rounds, Sisi read a book under the window. The ward was well lit. At that time, the morning sun shone into the ward and shone on Sisi's body. She looked so peaceful, so calm and composed.

Yang Ping really wanted to know what the inner world of this little girl was like, why she could be so calm in the face of death, most adults couldn't do this.

In the afternoon, Yang Ping came to Sisi's ward alone for rounds. Sisi sat under the window and read a book again. The golden sunset had not yet faded, and it sprinkled on her body. Sisi looked like a beautiful flower.

Yang Ping walked over slowly, and Sisi closed the book.

Yang Ping glanced at Rabindranath Tagore's poetry collection. The page she just read was "Living Like Summer Flowers".

"Are you scared? Sisi."

Now there were only Yang Ping and Sisi in the ward. He decided to talk to her. Yang Ping stood next to the pot of cactus.

Sisi smiled, and her face was flushed with the unique blush of teenagers: "I was scared before, but I am not afraid now. I have read a lot of books since I got sick. The math teacher once told us that we would learn the laws called axioms in middle school. Axioms do not need to be proved. They are correct. I found that there are also two self-evident axioms in medicine, or axioms that do not need to be proved. I don't know if it is right, and I don't know if there are such axioms in other books."

She actually summarized axioms, and they were axioms in medicine. Yang Ping was very curious about what this weird little girl was thinking about.

"Tell me about it, let me see whether this axiom is your original or a coincidence with the results of predecessors." Yang Ping smiled.

Sisi thought for a moment and said, "You can't laugh at me when I say this, and you can't say it's a child's talk."

Yang Ping quickly said, "I promise, I won't laugh, and I won't treat it as a child's talk."

Sisi lowered her head and thought for a while, then raised her head and said, "Everyone will get sick, and everyone will die of illness."

Yang Ping repeated this sentence in his heart, and was surprised. What a smart little girl, she really gave a very profound philosophical interpretation of the disease from a certain perspective.

Everyone will get sick, and everyone will die of illness, that's absolutely true.

Borrowing a common concept in oncology: 5-year survival rate, in a sense, the difference between normal people and patients, or even between normal people and cancer patients, is just the difference in the five-year survival rate, and both are less than 100%.

In layman's terms, birth, aging, illness and death are inevitable for everyone, and everyone will eventually die, but the age at which this end point is different is different.

At this time, Yang Ping didn't know what to say. He could only use the efforts he was making to give the little girl a glimmer of hope, even if she didn't need it now, but Yang Ping felt that he was a doctor and had the responsibility and obligation to give patients with terminal illnesses a glimmer of hope, even if it was comfort, even if it was care.

"I am trying a new treatment method, using viruses to carry factors that can kill tumor cells to treat you. These viruses are injected into your body, and they are carried to all parts of the body by the blood. They can penetrate the blood-brain barrier, infect those tumor cells, and then use the lethal factors they carry to kill tumor cells. Our viruses have been successfully modified, and these viruses have been cultivated in the laboratory and will soon be injected into your body."

Sisi always keeps a bright smile on her face, like an angel: "I said that the eyes are the windows of the soul. I can see from your eyes that you are comforting me. This treatment plan takes more than ten years from design to clinical application in medicine, and the success rate is pitifully low, often less than one percent, but I am willing to be your experimental subject. I once said that I am willing to be your wrong question book."

'Have you read books or papers on this subject? "Yang Ping was very surprised.

Sisi nodded: "Didn't you apply for a library card for the hospital for me? I often go there to read books and magazines, so I know a little bit. "

"You will definitely be a good doctor when you study medicine in the future. "Yang Ping encouraged her, although it was just a lie to her.

Sisi pursed her lips: "I have a favor to ask you, have you asked for me? I don't know if the bodies of cancer patients can be donated to medical schools. If so, I want to donate my body to Nandu Medical University as a specimen for medical students. I said before that I would study medicine with you, but now it seems that I can't do it. If I can donate my body to Nandu Medical University as a cadaver teacher, wouldn't it be another way to enter the medical field and realize my dream. "

Can't empathize!

Yang Ping told himself in his heart, but he couldn't help it, his eyes were wet.

"Can you agree? This is the last request."

"Yes!"

Yang Ping turned his head and looked at the pot of cactus in the corner. He didn't want Sisi to see him crying. He has always been a confident and omnipotent big brother in front of Sisi.

''Are you a professor at Nandu Medical University?"

"Yes."

Yang Ping deliberately lowered his head and fiddled with the cactus.

"Then you will definitely go to class." Sisi looked very happy.

Yang Ping's voice was a little hoarse: "I have a class every week."

"Is it anatomy class?"

'No, it's "Surgery", taught to senior medical students. '

'Is that so...'

Sisi's tone was a little disappointed.

"What's wrong?"

"If you go to anatomy class, then I can listen to your lectures every week..."

Yang Ping took a deep breath, tears streaming down his face, his throat was blocked by something, and he could no longer speak.