The Godfather of Surgery

After the new plan was determined, everyone started to get busy again. Two routes are now open for tumor treatment, and a third route or even more routes may be opened in the future.

When manpower and funds can afford it, fill up the possible technology tree, and then make choices based on the situation. This is the most reliable way.

The path of combining scientific research and clinical practice is getting wider and wider. Yang Ping is very satisfied with his decision at the time. If there is no strong scientific research strength, Sisi's treatment can only circle in the old method, like entering a dead end, and there is no hope at all. With strong scientific research as support, Yang Ping can study new methods to solve problems and then promote the innovation of some medical technologies.

Yang Ping thinks that Tang Shun is right. Cell therapy has a bright future in the future. It will develop a huge system. Stem cells are just a branch of cell therapy, so Yang Ping decided to expand the stem cell experiment and upgrade it to a cell therapy room. For the time being, it is just a change of sign. In the future, the talent team and laboratory space will be expanded.

In the future, Sanbo Laboratory will need a whole building, or even several buildings, instead of shrinking in these few floors. Yang Ping calculated the space that can be used in the Institute of Surgery. If it continues to develop like this, the space here will soon be used up.

The cell therapy laboratory will soon establish a ward to apply the research results to clinical practice, such as conducting CAR-T cell therapy with a cost of 1.2 million per injection, and will also conduct CAR-NK cell therapy in the future, as well as the K-NK cell therapy that is currently being tested.

Once the clinical ward for cell therapy is established, the stem cell therapy ward will also need at least one floor, because the patients who can afford stem cells are either rich or noble, and the ward conditions cannot be too shabby, at least single rooms should be provided. Other cell therapies will also require one floor. So the cell therapy side will require three floors, and three floors are still relatively tight. One floor for the tumor laboratory, one floor for the surgical ward, one floor for the independent ICU that will be opened soon, one floor for the operating room, and one floor for the outpatient department. With this calculation, the eight floors have been fully used, and it seems very tight. Because one floor is definitely not enough for the surgical ward, and it is already very tight. In the future, with the increase of interns, doctoral students, and master's students, a separate floor will be needed for teaching, otherwise everyone will be crowded in the ward, and the space will be very tight.

This is just the initial development, and this building is definitely not enough. Yang Ping immediately reported his needs to Dean Xia, hoping to find a piece of land in the hospital to open up a new area for laboratories. Separate the surgical research institute and the laboratory, so that there will be much more space.

These things are already in Dean Xia's plan. There is still a lot of land that can be developed in Sanbo Hospital. Dean Xia has planned an area specifically for laboratories. Even if the hospital has no land now, he only needs to report it to the higher-ups, and soon a piece of land will be approved for him.

As for the money, with the current status of Sanbo Hospital, no matter how much money is, it is not a problem. After being the dean for so many years, this is the first time that Dean Xia is not worried about money. In the past, he always ran out every few days for money, and he only made a little money by drinking until he had gastric bleeding. Now, as long as he reports it, the money will be credited immediately.

Dean Xia has done a lot of things as the dean over the years, but he has never sought personal gain. He is strong without desire, so he is not afraid of anything and dares to do anything. Because he has no handle, he will not shrink back from doing things. For some unreasonable things, he dares to speak up and argue with reason to his subordinates and superiors.

Dean Xia has also been thinking about the expansion of the hospital recently. Once cell therapy develops, the scale of the oncology department will definitely expand, and then the tumor surgery department will also expand. The surgical research institute can not be expanded now because of manpower problems. If it is expanded, it is estimated that it has expanded several times to the current size.

Now Sanbo Hospital is expanding its scale slowly and in a controlled manner, and the quality must be guaranteed while expanding. The scale of a hospital is not the bigger the better. When a hospital develops to a certain extent, it needs to focus on some cutting-edge technologies instead of grabbing the jobs of grassroots hospitals. In that case, no matter how big the scale is, it is meaningless. It is nothing more than squeezing out grassroots hospitals and grabbing the source of diseases from grassroots hospitals to yourself. Such a large scale is meaningless. It was originally a dense forest, but now a tree absorbs all the nutrients in order to grow taller and bigger. The whole forest finally dies. What is the meaning of this lonely tree?

Therefore, Sanbo Hospital is very cautious about expanding its scale. It will not expand blindly and meaninglessly. It will be strong first and then big. It is not big without strength, but to be strong.

——

After adding the plan, the researchers in the laboratory should be frustrated, indicating that the original experiment has encountered difficulties. Now they need to change their thinking and increase the workload, and the future of the new plan is still unclear.

But now the researchers in several laboratories are not only not frustrated, but they are all very excited like chicken blood. Because the K virus treatment research has achieved a success from 0 to 1 so far, this success is groundbreaking. Not to mention that there was such a high tumor elimination rate before, even if it is lower, as long as it is not zero, it is a success.

The virus laboratory of Nandu Medical University used to be a purely auxiliary marginal role, but now it has transformed into a leader, because Yang Ping has delegated this project to them, it would be strange if they are not excited.

Lu Xiaolu's tumor laboratory was originally only responsible for the K virus treatment project. Now, they are the leaders in both K virus treatment and NK cell treatment. One team is simultaneously spanning two of the world's top projects. How can they not be excited?

The stem cell experiment has not only received the topic of NK cell therapy, but has also been upgraded to a cell therapy laboratory. The research scope has been expanded several times. Immediately afterwards, the personnel, funds and experimental sites will also be expanded several times. Tang Shun’s team estimates that it will be several times in a few days. I wake up laughing every night from my dreams.

Researchers in several laboratories follow big bosses like Yang Ping. They need projects, funds, and equipment, and they are all in large quantities. Which one of them is not happy and which one is not excited? They have applied before. You have to pull your hair out to solve a project. In the end, funds are tight, and the results may not come out in the end. Nowadays, the world's top topics are readily available, success will be achieved when you tell the results, and you can publish articles and have your own journals. This kind of scientific research conditions cannot be found anywhere else in the world.

The road to this subject is now getting wider and wider. Yang Ping's thoughts on the entire subject are now very clear. He is building a subject system with K factor as the core. This K factor is very special as a cytokine, which was not found in the human body in the past. was not discovered. This time it was also discovered while culturing Sisi's tumor cells. This discovery process is actually worth thinking about. Maybe we can use the process to develop a method of creating or discovering new cytokines.

The human body has endless mysteries. Current biomedical science has only really understood a small part of it, and the unknown areas are still vast. This aroused Yang Ping's great curiosity.

K factor was originally discovered by Yang Ping accidentally. It was an unintentional result. At that time, he analyzed the components of the culture medium in which Sisi tumor cells were cultured in vitro and found some protein molecules that were not found in the mother liquid. This large protein molecule was K factor. Later, it turned out that Many tumor cells die automatically. After analysis, it was found that it is this K factor that initiates the apoptosis program of tumor cells. This discovery is in line with the traditional wisdom that "there must be an antidote within five steps."

Yang Ping decided to study the discovery process of K factor as a topic. Why does this K factor appear when tumor cells are cultured in vitro? If the mystery can be cracked, it will open a door to a new world in the future. .

——

Embedding K factor into NK cells is a genetic engineering task, so Yang Ping handed it over to the genetics laboratory of Nandu Medical University. They have high-level gene recombination technology. These topics of Yang Ping will bring the entire The laboratories of Nandu Medical University have been mobilized and brought directly to the world's top academic level.

The structure of factor K is very special. From the analysis of its gene sequence, it is a combination that contains an antigen receptor structure, a cytokine structure, and a protein molecular structure suitable for cell armor. Antigen receptors are responsible for identifying tumor cells, and special cytokines are responsible for initiating the apoptosis program of tumor cells. It contains molecules similar to perforin and granzyme, but its effect is many times that of perforin and granzyme, so it is both It can act both outside the cell and inside the cell.

Yang Ping wondered whether immune cells and various immune factors were mixed into the specimen when tumor cells were cultured, and some combination occurred in the special culture environment to form the current k-factor.

If so, Yang Ping formed a new idea. Can the K factor be split? The antigen receptor part acts as an antigen embedded on the surface of NK cells and is responsible for identifying tumor cells. Factors that can kill tumor cells are embedded in granzyme and perforin, allowing them to be released and enter tumor cells. They are protein molecules that have the effect of cell armor factors. Also embedded on the cell surface. "

Yang Ping feels that only in this way can it work. Otherwise, the whole thing embedded on the cell surface will not work at all. Factors that can kill tumor cells cannot be released. Then the NK cells will only obtain cell armor and antigen receptors, and their combat effectiveness will be greatly weakened.

Such NK cells are perfect in theory. Under the guidance of antigen receptors, factors that can kill tumor cells penetrate tumor cells, enter the interior of tumor cells, and complete the task of hunting tumor cells.

Yang Ping discovered a very interesting phenomenon. The combination of K factor and NK cells is so perfect. It can easily break through many problems faced by current NK cell therapy. K factor is simply a tailor-made partner for NK cells.

Yang Ping spent more than 100 paintings and imagined more than 100 possible combinations, and then used his optimization method to divide these more than 100 combinations into levels.

In the afternoon, Yang Ping took these pictures to the genetics experiment to communicate with Lin Lan. Lin Lan is Su Nanchen’s wife and Yang Ping’s sister-in-law. She is an excellent genetics scholar who once studied in the United States and is a graduate of Nandu Medical University. She was recruited with an annual salary of two million, and she became a doctoral supervisor at the age of 28, and was a very good genetics scientist.

Yang Ping told Lin Lan his idea, and then handed the experiment plan to Lin Lan. Lin Lan was very surprised after reading it. This experiment is a big project, from genetic recombination, cell culture, structural retesting, etc., the entire scientific research process The cost is staggering, and it is estimated that it can use up the scientific research funding of Nandu Medical University for a year.

Lin Lan said in embarrassment: "The goal of the experiment is achievable, but it involves the reorganization of more than a hundred different plans, and this reorganization is very complicated. It is not a simple reorganization. The scientific research funding is too high and it is simply unaffordable. We as a whole The school's annual funding is only so much. If I were to complete all of your projects, I would almost have to build a new laboratory. The various expenses would not be worth a few hundred million. "

"Funding is not a problem. All funds are covered by our fund. You give me a detailed budget and I will give it to Sanbo Research Fund. They will be responsible for the funds of the entire experiment." Yang Ping said lightly.

Lin Lan forgot that Yang Ping had a research fund. This fund is open and transparent. I heard that there are billions of funds in the account, and the fund pool has been increasing.

"You are responsible for everything. Do you mean that we don't have to pay a penny to participate in this project?" Lin Lan was quite surprised.

As a family, Yang Ping nodded: "You provide people and technology, and we pay for it. This project will use gene recombination technology in many places, and we will set up a cell therapy laboratory soon. At that time, the demand for gene recombination technology will be even greater."

Lin Lan knew very well that cell therapy has a great demand for gene recombination. Its first step is to perform various recombination on immune cells to obtain immune cells that meet the requirements.

Please...collect_6_9_book_bar (六//九//书//吧)

It turned out that Lin Lan's K virus treatment task was relatively simple. Recombining K factor with adenovirus was also considered marginal auxiliary work. Now she has joined the new topic of NK cell therapy and has obtained hundreds of millions of scientific research funds at once. And this has just begun. This brother-in-law is really generous.

"In this case, what are we worried about? As long as it is genetic recombination work, you can leave it all to me. If there is not enough manpower, I will immediately recruit people. This year is not to set up cell therapy laboratories, and all genetic research will be handed over to us. How about it?"

What else can we do? We are all family.

"Of course." Yang Ping agreed on the spot.

Lin Lan was a little confused. When she was in the United States, she had never seen such a straightforward scientific research fund. A few hundred million was a matter of a word, and it was estimated that more than ten billion would be available in the future. In this way, her genetics laboratory took advantage of this favorable wind and became the world's top.

Lin Lan continued to read Yang Ping's research plan, and the more she read, the more surprised she was. This topic is not simple, and it simply crushes other NK cell therapy research in the world.

"We guarantee that you will be satisfied with the work on gene recombination. According to your opinion, we will split the K factor. Don't worry, after the split, we will make the recombined perforin and lysosome more powerful, allowing it to easily enter the cell and then release the lysosome with enhanced combat effectiveness." Lin Lan said happily.

Yang Ping said: "We want this effect."

"Nan Chen is coming, let's have dinner together." Lin Lan put away the research plan.

Yang Ping didn't expect them to be so polite: "Don't be polite, you are busy too, I have to go back too."

"That won't work, it's time for dinner now, you can't leave, we must have dinner together, it's a rare trip." Lin Lan said with a smile.

Don't you come here often? Why do you say it's rare?

"Really don't be polite, I'm in a hurry." Yang Ping thought it was better to go back.

Lin Lan smiled and said, "Nanchen is coming soon. I tell you, last time you came to Nandu Affiliated Hospital No. 1 and went back on an empty stomach, your father was criticized by Su Xiaomei. You should listen to us and stay here for dinner. If you go back on an empty stomach like this, your elder brother and I will be criticized by Su Xiaomei again."

"Yes, the princess of the Su family is someone who cannot afford to offend anyone. How could she let her husband go back on an empty stomach?" Su Nanchen has arrived.

PS: James P. Allison, the winner of the 2018 Nobel Prize in Physiology or Medicine, has mentioned many times in interviews and articles that stem cell therapy and immunotherapy have the potential to become the core means of future medicine. In an interview with Nature, he said, "We are at the beginning of a new treatment model that will allow us to more deeply manipulate the immune system and achieve real control of cancer and other diseases." The way to conquer cancer in the future may be cell therapy. In fact, CAR-T cell therapy has conquered some blood tumors. And CAR-NK cell therapy is a newer generation of immune cell therapy.