The Godfather of Surgery

In Yang Ping's office, there are all kinds of weird pictures on the whiteboard, including the structure of NK cells and the structure of vector adenovirus. Yang Ping stared at these pictures in a daze, completely lost in thought. Even if the sky fell at this time, he probably wouldn't have any reaction.

Now he is used to thinking about problems in the office. The light and air in the office are good, and the sound insulation measures are very good. It will be very quiet when the door is closed, and generally no one will disturb him. People from his department will contact him in advance via WeChat if they want to come to the office, and knock on the door after confirmation, and will not knock on the door rashly. Everyone knows that Professor Yang is thinking about problems in the office, not doing other things. When thinking about problems, it is most taboo to be disturbed by others. Interrupting thinking is a very annoying thing, so everyone is conscious of nonsense and will never disturb Professor Yang rashly, unless there is a fire or something like that, and emergency evacuation is required.

There are so many kinds of human immune cells, T lymphocytes and NK cells are just one of them. Yang Ping is thinking whether to include other immune cells in the research scope one by one, and then see which cells are easy to use and easy to be transformed. In this way, a large amount of basic data on immune cell therapy can be accumulated. Regardless of whether a breakthrough success is achieved, it will lay a solid foundation for the future.

Virus therapy is actually promising, because viruses can invade the interior of human cells, which is incomparable to immune cells. Immune cells are cells anyway, and they are at the same level as tumor cells in the biological structure level.

Viruses are one level lower than cells in the biological structure level. They are at the same level as the organelles in the cell. Its biggest advantage is that it is very small compared to cells, and it can penetrate the cell membrane and enter the cell. In theory, viruses are easier to deal with tumor cells than cells.

Viruses and cells, the biggest advantage of cells is that they are the body's own immune cells, which will not be attacked by themselves, and they have their own navigation equipment and various weapons. The biggest disadvantage is that they are at the same biological structure level as tumor cells. The biggest advantage of viruses is that they are lower than cells in terms of biological structure. The biggest disadvantage is that they are always foreign objects. They need to face the human immune system and have no weapons. They must be embedded with weapons using genetic engineering technology.

Can this vector virus be combined with immune cells, and the fragment structures such as antigen receptors and tumor necrosis factors on immune cells can be transplanted to the virus to form a new virus. In this way, the virus can also recognize tumor cells like immune cells, and then penetrate tumor cells into the cells, and then release tumor necrosis factors and the like.

Thinking about it, Yang Ping suddenly realized it!

Why didn't I think of this? If this combination is done, what is the K factor? Why should the entire research be arranged around the K factor? It is completely unnecessary, and the entire research will become more open.

"At first it was very narrow, but it was only then that people could pass through it. After walking a few dozen steps, it suddenly became clear."

Suddenly became clear!

Thinking of this, Yang Ping felt like he had passed through a narrow passage and entered a state of sudden enlightenment.

K factor, why did K factor appear when Sisi's tumor cells were cultured in the laboratory? This is not accidental, there must be a reason. Before, Yang Ping thought about how to use K factor to treat tumors first, and then slowly study why it appeared in the culture medium when he had time. Now Yang Ping has found the reason, and he has touched the essence of things.

When Sisi's tumor cells were extracted, immune cells must have been mixed in at the same time, because the in vitro culture environment of the laboratory is tailored for tumor cells. These immune cells cannot survive normally in the in vitro culture medium of the laboratory, so they change in a special environment, and the cells die and disintegrate. However, during the disintegration process, some fragments float in the culture medium and are combined and pieced together to form K factor.

Yang Ping thought of some hypotheses about the earliest life on Earth. Some scientists believe that the earliest organic matter on Earth should be related to lightning. It was the trillions of lightning that released phosphorus compounds.

The time should be about 3.5 to 4.5 billion years ago, when some simple compounds necessary for life were released on Earth, which laid the foundation for the birth of life later. In short, all life on Earth is likely to have originated from lightning. Pyroxene formed when lightning strikes volcanic rocks contains phosphorus. Subsequently, a large amount of phosphorus accumulates in volcanic ponds and other waters. Phosphorus can accelerate the formation of biological molecules.

The chemical substances in the early Earth mainly include water, ammonia, methane, etc. According to this hypothesis, it is lightning that stimulates these substances to react. In order to verify this conjecture, in the early 1950s, Stanley Miller and Harold Urey of the University of Chicago conducted an experiment. They filled a closed chamber with water, injected ammonia, hydrogen and methane, and then repeatedly stimulated it with electric sparks. After a week, they detected 20 different amino acids in the contents of the chamber.

There are also scientists who believe that solar particles may be the reason for stimulating the early life substances on Earth, but whether it is lightning or solar particles, they only have different energies for stimulation, and the latter promotes the formation of simple organic matter.

Isn't the formation of K factor similar to the formation of early life on Earth, but the formation of K factor is much easier than the formation of early organic matter on Earth, but they are all a coincidental recombination.

Yes, this is the essence of the K factor. The more Yang Ping thought about it, the more he understood. It was like running along a dark tunnel. He saw a glimmer of light and then ran towards the light. The front became brighter and brighter. Finally, a vast and bright world appeared in front of him.

If this is the case, then K factor must be a combination of gene fragments of human immune cells. If they are split according to function, the same fragments can be found in the genomes of various immune cells in the human body. Yang Ping put forward his own hypothesis.

But is it? This requires splitting the K factor gene fragments according to function, and then rigorously comparing them with the genomes of various immune cells.

This is another big topic! The ideas quickly became clear, perfect, and mature.

Contact Lin Lan immediately, contact the heads of all laboratories, and bring them together. Yang Ping wants to carry out a brand-new research. The K factor is just a gadget. The reason for its formation is the most worthy of study, and that is now The essence of all research.

"Song Zimo, come to my office, immediately, immediately, now!" Yang Ping called Song Zimo immediately.

As soon as Song Zimo heard the call, he didn't dare to delay and immediately came to the director's office. Yang Ping was leaning on the back of his chair and staring at the pictures hanging on the whiteboard in a daze. Song Zimo went over and asked, "Professor!"

Yang Ping didn't say anything. Song Zimo felt a little nervous. The professor called him here in such a hurry and now he didn't say a word. Did he make any mistakes? His mind was spinning rapidly. The recent surgeries went smoothly and there were no complications. There have been no mistakes in any work recently.

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"professor!"

Yang Ping still didn't speak.

The drumbeat in Song Zimo's heart became more and more intense.