The Godfather of Surgery

In the recent short period of time, Professor Yang has launched a series of big projects, which makes everyone feel incredible.

Professor Yang must be an alien. His imagination is off the charts. In just a short period of time, he has proposed several extremely creative research directions. Each one is heavyweight and is a step forward in exploring medical problems. .

In fact, in addition to a solid knowledge base, scientific research also requires rich imagination and strong curiosity about the unknown world. Only in this way can the originally boring research be regarded as interesting work, and unconventional research can be achieved and some breakthroughs can be achieved. Sexual achievements.

These research topics proposed by Yang Ping, even if we don’t talk about whether these researches can be successful, even these ideas are very groundbreaking and can provide rich inspiration and open a door to a new world for those who come after us.

The discussion continues, and everyone's topics are being discussed and adjusted again and again, and now they are constantly becoming more aware and mature.

"Are you saying that some fragments of immune cells after disintegration can be freely combined under certain conditions to form new and larger fragments? For example, this is how K factor comes." Lu Xiaolu asked, he felt that this The idea is a bit wild. No one has ever thought of this happening before in the cell culture medium grown in the laboratory.

Yang Ping nodded and said: "In the ancient times of the earth, lightning or solar particles may have stimulated some chemicals to form organic matter. In the culture medium of the laboratory, those gene fragments may have been randomly recombined. However, it is only a hypothesis at the moment. It needs to be Rigorous experiments to verify.”

In fact, many advances in science start from genius hypotheses, such as the double helix structure of DNA and the mosaic structure of cell membranes. They all start from a genius hypothesis, and finally experiments verify that the hypothesis is correct.

"If this hypothesis is established, we will be able to create a theory and unravel some of the offensive and defensive principles behind the immune system. At that time, our entire research ideas will be broadened, and the treatment of tumors will be brought into a free state." Yang Ping added.

Everyone was inspired by Yang Ping's words to have great confidence, and they all secretly decided to give it a try.

Lu Xiaolu took over and said: "It is necessary when multiple topics are carried out at the same time. The shortcoming of current immune cell therapy is its lack of ability to treat solid tumors. For example, T cell therapy is effective for blood tumors, but not effective for solid tumors because Blood tumor cells are floating in the blood, and immune cells are also floating in the blood. In the liquid, it is like a sea battle, these cells are like warships, and warships use the sea as a platform to fight. The immune cells deal with solid tumors like urban street battles. In urban street battles, warships cannot play a role. "Lu Xiaolu originally said. I am studying tumor immunotherapy, so I am very familiar with these.

"Yes, but the virus-carrying virus does not have this shortcoming. It can penetrate any solid tumor and enter the inside of tumor cells. Therefore, whether it is a hematological tumor or a solid tumor, there is no obstacle to carrying the virus." Professor Zhang Zhiwei expressed his opinion.

"We have carefully studied the internal and external conditions for the formation of K factor at that time. After studying these conditions more clearly, we can decipher the formation process of K factor." Tang Shun said that at that time, K factor was used when culturing tumor cells in the cell laboratory. discovered.

"Yes, if we can study the formation mechanism of K factor clearly, we can recombine similar biological factors in the laboratory in the future." Yang Ping affirmed everyone's opinions, "Regarding viral therapy and cell therapy, let's talk about the current international research progress. How about it?"

Lu Xiaolu studies tumor treatment, and he took the initiative to undertake the task of introducing:

"The most successful cell therapy currently is T cell therapy. I won't introduce its history in detail. In a clinical trial for patients with residual or recurrent brain malignant tumors "glioblastoma", a team in the United States underwent oncolysis. 16 of 19 people treated with viral drugs survived for more than 1 year , 3 of them survived for more than 5 years, and their tumors became smaller and did not relapse. However, under traditional treatment, 80% of patients with recurrent glioblastoma will die within 1 year. Viral therapy has shown great promise, so its promise is proven."

"As for the current progress in virus treatment, the most advanced Japanese research results are the oncolytic treatment products after recombinant herpes simplex virus type 1. Herpes simplex virus type 1 has three important genomes: α34.5 gene - —The human body has a self-protection mechanism. Infected cells will self-destruct, thereby preventing the virus from multiplying. However, the α34.5 gene will try to prevent this and allow the host cell to continue to survive. They used genetic technology to disable α34.5 and prevent the virus from growing inside the cancer cells. Can also proliferate the ICP6 gene— - It produces an enzyme that can synthesize viral DNA. If it is not allowed to function, the virus cannot multiply in normal cells, so it only multiplies in tumor cells. The α47 gene has the ability to make it difficult for the human immune system to detect the virus. Stealth function, if this group of genes is manually deleted , the virus loses its stealth ability. Originally, cancer cells are the patient's own cells, so the immune system does not consider them as enemies. However, when tumor cells are infected by viruses that have lost their stealth function, they will be "marked" and the cancer cells will be easily attacked by the immune system. found, thus becoming the target of attack by the immune system.

"Japan is currently the most advanced viral therapy, but it took 20 years for their products to be researched and put into use, and the results are not ideal. They can only be used as auxiliary products, such as to shrink tumors before surgery, so as to facilitate surgery. , and our route is completely different from theirs. They just use the virus as a marker and then attract the immune system to attack. In essence, it is still immunotherapy. "

"Our viral therapy truly uses the virus to penetrate, mark and hunt, relying on the virus to complete all functions, so we have to reverse certain steps, such as the invisibility cloak function of the α47 gene. We are not eliminating this function. , but strengthen.”

"Cell therapy is currently the most advanced in the United States, and CAR-T cells are the most mature in application and the best in commercialization. Compared with viral therapy, cell therapy has already achieved a curative effect on certain tumors, so everyone is familiar with it. Our laboratory is currently also CAR-T cell therapy is being carried out, so I won’t talk much about cell therapy.”

''We will surpass them in the near future. We are already ahead of them in basic research in this area, and these newly opened topics will definitely occupy the forefront in this area. "Yang Ping said without humility that for Yang Ping, there is no need to be modest in this regard.

"My idea of ​​viral therapy has a flaw. No matter how we improve it, its inherent shortcomings cannot be eliminated. It is a foreign object and will be attacked by the immune system. However, immune cell therapy does not have such a flaw. If we use the idea of ​​oncolysis, , In fact, it has no lethality, and the Japanese have been doing it for 20 years. "Tang Shun still thinks that cell therapy is more promising.

Professor Zhang Zhiwei disagreed: "The poor effect of cell therapy on solid tumors is also a flaw. Cells penetrate the blood vessel wall from the blood vessel, and then penetrate layer after layer of barriers. It is also difficult to enter the tumor. The virus can easily enter the parenchyma. Inside the tumor. As for the virus being attacked by the immune system, it can be evaded. Didn’t Professor Lu just say that the α47 gene carried by herpes simplex virus type 1 is a recessive gene? I think this gene also exists in adenovirus or other viruses. We can use recombinant technology to enhance this function, even if other viruses do not. We can implant genes for this, it’s not difficult.”

Yang Ping’s team’s academic conference discussions have always been straightforward. We don’t need to play around with sophistication, which can improve communication efficiency and avoid ineffective losses.

"It doesn't matter. We don't need to argue about who has more prospects in the future now. It's all left to the future to judge. We have to study all possible routes. In the process of research, we may learn from each other and learn from each other's strengths. We also have to start the third Three routes, implanting some genomes on immune cells into carrier viruses such as adenovirus, can be achieved Of course, this is just an idea of ​​mine, but it doesn’t matter. Don’t put any psychological burden on everyone. Scientific research does not say that it must be successful but must produce results. Everyone should relax and study. If the path doesn’t work, adjust at any time. If you can go Just keep going." Yang Ping said, don't worry, there are enough funds for scientific research and there won't be any bias.

"Everyone's respective topics are independent, but at the same time they are part of a larger topic, so everyone shares data during the research process. This can inspire and learn from each other. Different fields need more communication, and maybe in the process of communication New things can emerge, and no one can tell what the future will be like, so we can only cross the river by feeling the stones.”

Now that there are sufficient funds for scientific research, Yang Ping wants to provide everyone with a relaxed and free scientific research environment without being burdened with utilitarianism.

"Professor Yang, I want to know how much funding you are going to inject into our research project this time? This will give me a better idea, because the team needs to be expanded, equipment needs to be added, and the scale of the entire laboratory needs to be expanded." Lin Lan asked directly about the funding. The problem is that it is impossible to carry out these studies with the existing team size and laboratory hardware conditions, and if you want to expand, it will not be a small amount of money. You have to rely on yourself. The scientific research funds invested in this topic in the past ten years are not enough.

"Yes, I want to know too, so that I can know what to do next." Professor Zhang Zhiwei is also very concerned about this issue.

Lin Lan and Professor Zhang Zhiwei are professors at Nandu Medical University. Although they are familiar with Yang Ping, they are not very clear about the details of his scientific research fund. They only know that he has a scientific research fund, but they still don’t know what his strength is.

Now that Yang Ping has set up such a big business, these two professors are very eager to join his big team, but after careful calculation, they found that the investment is not small.

Tang Shun and Lu Xiaolu are from Sanbo Hospital, and they are very aware of the strength of Yang Ping's scientific research fund. Especially Tang Shun, who was originally the gold medal "salesman" of the scientific research fund and brought in a lot of money for the scientific research fund. For example, the stem cell treatment project has attracted hundreds of millions of dollars in funding, and this amount is still increasing.

Yang Ping looked at everyone and paused. He usually didn't care much about money. If he was asked to name a number, he really couldn't come up with it. He could only say: "Enough!"

No matter what, this answer is rather vague, which is equivalent to no answer.

At this time, Tang Shun took over the conversation: "Professor Yang usually doesn't care about the money in the fund account, so he is not sensitive to money. He certainly can't tell the specific number. After you make the budget, he can guarantee to sign and pay the money. If you must tell me the amount of funds for a plan, I will tell you the bottom line. For this big project, we have no problem investing 1 billion in the first phase."

This book has been updated recently in ##六@@九@@@书@@吧!! Update!

1 billion?

It is indeed rich and powerful. I heard that Professor Yang is not short of money. The legend is true. He is so low-key at ordinary times, but he can actually take out 1 billion research funds at a time.

Lin Lan, Professor Zhang Zhiwei, and several of their assistants were stunned when they heard this number. They had never heard of so much funds being given at one time. 1 billion, several research groups, each of them can get 200 to 300 million, which is already a very huge number.

"I have an idea in my mind. Let's start the work and make a budget as soon as possible." Lin Lan was extremely excited. Finally, he didn't have to be frugal.

Professor Zhang Zhiwei was so excited that his hands were shaking. According to this calculation, his research group could get 200-300 million yuan, and that was for the early stage.

"Only 1 billion yuan? How could so many research groups get so little? Didn't they say they would take out 5 billion yuan?" Yang Ping was a little dissatisfied with this number, and immediately asked Tang Shun why the funds had shrunk. He was usually very generous, so why was he so stingy now? There was no need to hide his wealth in such occasions.

After Yang Ping's questioning, Tang Shun immediately realized that he had said something wrong. He had studied abroad before and was used to speaking US dollars.

"Professor, it's US dollars. I said 1 billion US dollars, not RMB." Tang Shun hurriedly explained.

US dollars? 1 billion?

Lin Lan's eyes were originally big, and now they opened even wider, looking at Yang Ping, waiting for his confirmation. He was not joking.

Professor Zhang Zhiwei's hand holding the teacup shook, and the tea spilled directly on the table. My goodness, what kind of local tyrant is this? He just took off. He had all the equipment he wanted and dug up all the people he wanted.

"Professor Yang? Don't scare me, are you telling the truth?" Professor Zhang Zhiwei quickly took out a pack of napkins and threw them on the tea on the table, saying as he soaked up the water.

"That's right, because a lot of our research funds are received in batches, sometimes there is not much cash on the books, so there is only so much for the first phase, and then we will allocate more funds based on progress and needs." Yang Ping confirmed the number reported by Tang Shun.

Professor Zhang Zhiwei now feels like he has never seen the world.