The Science Fiction World of Xueba

Chapter 399 Endogenous retroviruses

After a moment of silence, Ashford said again: "Professor Pang, I have another unfeeling request."

"Please say."

Ashford said: "Professor Pang, I hope that you can help me save Angela before breaking up with Spencer. I know that you and that Ms. Alice are not ordinary people. With your abilities, there is There is a way to get Angela back from Spencer."

Pang Xuelin smiled faintly, nodded and said, "Don't worry, Dr. Ashford, since I can save Angela once, I can save her a second time."

Ashford said gratefully: "Professor Pang, thank you."

Then, Pang Xuelin chatted with Ashford about other issues. It was not until nine o'clock in the evening that Ashford pushed the wheelchair and slowly returned to the villa.

Pang Xuelin smiled, waited until Ashford's back completely disappeared at the door, and said, "Come out, everyone is gone, there is no point in hiding any longer."

The night wind blows the branches and leaves of the green belt rustling, and from time to time, withered yellow leaves fall down.

After a while, a black figure stood out from behind a sycamore tree.

"How did you find me?"

Alice was a little curious.

"I hear your breathing."

Pang Xuelin smiled faintly.

A look of astonishment flashed in Alice's eyes. After being transformed by the T virus, her control over her body can be said to have taken a qualitative leap.

On weekdays, breathing is extremely soothing, but tonight is another windy day. Under such circumstances, Pang Xuelin can still distinguish his own breathing from the noisy environment around him, which is enough to show the strength of the man in front of him.

Alice no longer struggled with this topic, her beautiful eyebrows were slightly frowned, and she asked in doubt: "Do you think the method Ashford said can really help us find a way to deal with the T virus?"

Pang Xuelin shook his head and said, "I don't know, but what Ashford said about starting with non-coding RNA is indeed feasible."

Alice said: "I don't understand academic things. I can only kill people. If you want to kill someone or save someone, I can help you."

Pang Xuelin smiled slightly and said, "Thank you, but there is no need to kill people. I have another important task for you."

"What task?" Alice asked curiously.

Pang Xuelin said: "Although the Umbrella Company still hopes to get the new virus manufacturing method from me, the Kempten base cannot always rely on the material support of the Umbrella Company. Next, I hope you and Jill can lead a team to sweep around Towns, collect useful materials and transport them over. Including food, oil, various machinery and equipment, vehicles, etc. In the next year, our main task is to store various materials besides building bases."

Alice was taken aback for a moment, nodded and said, "No problem."

Pang Xuelin hesitated for a moment, and said, "There is one more thing that needs your help."

"What's up?"

"I chatted with Jill and the others before. The weapons and equipment in our hands are mainly light weapons, and the reserves are limited. I need someone who can lead a team to sweep the Hill Air Force Base in Utah..."

"Hill Air Force Base?"

Alice seemed a little puzzled.

Pang Xuelin said: "The Hill base is located about 30 kilometers away from Salt Lake City, Utah. It houses the 419th Fighter Wing, the 388th Fighter Wing, and the 34th Frontline Combat Squadron, the first US military equipped with F35A. In addition, it is the US Air Force logistics center for Deploy F22 fighters, F16 fighters, A10 attack aircraft and C130 transport aircraft around the world to provide an important base for engineering and maintenance services.

It also provides support and maintenance for active B-2, B1B bombers and Minuteman III intercontinental missiles and other weapon systems. Therefore, here is one of the three major logistics centers for US Air Force equipment and one of the five major maintenance bases. There may even be nuclear bombs in this base..."

Alice's eyes narrowed all of a sudden: "Are you planning to use nuclear bombs against Umbrella Corporation?"

Pang Xuelin shook his head with a smile, and said, "Just in case, even if the nuclear bomb is found, I will not bring it to the Kempten base."

Alice nodded thoughtfully, and said, "As for the sweeping of the Hill Air Force Base, you can let Jill organize candidates. There should not be too many people. I will lead the team then."

"Okay, thank you for your hard work."

"You're welcome. I hope you can remember your previous promise."

After finishing speaking, Alice ignored Pang Xuelin, turned around and quietly disappeared into the darkness.

Pang Xuelin smiled lightly and didn't say any more.

Early the next morning, Pang Xuelin began to find Jill and Claire to assign tasks.

At present, the Kempten base relies on the umbrella company for food, fuel, and other material consumption.

Moreover, there is no airport at the Kempten base, so the umbrella company can only dispatch a tilt-rotor aircraft similar to the Osprey to provide material support for the Kempten base.

Therefore, in order to completely control the base in his own hands, Pang Xuelin must mobilize the army in the base as soon as possible to collect supplies from the outside world on a large scale.

After arranging the tasks for Jill and Claire, Pang Xuelin called Spruce, Berkeley, Huang Yu and others, and introduced Ashford to them.

To Pang Xuelin's surprise, these people all knew Ashford.

From their mouths, Pang Xuelin learned that Ashford is also a well-known figure in the field of life sciences, and has made several quasi-Nobel Prize-level achievements.

Just because of working for the umbrella company. Ashford is not considered active in academia.

But since everyone knows each other, it would be great for Pang Xuelin.

The underground laboratory in the base was quickly activated and put into research on the T virus.

As a doctoral candidate in medicine, Xiaodongbei was also drawn into the research group by Pang Xuelin.

...

Half a year passed in a flash. In the past six months, Pang Xuelin devoted most of his time and energy to the laboratory and the study of biology.

When Pang Xuelin was in the world of "The Ninth District", he had studied the theoretical knowledge of biology.

But at that time, he hadn't been modified by the genetic optimizer. Therefore, although he had devoted himself to studying in the world of "The Ninth District" for three years, Pang Xuelin's level was not that high. Scholars from around the world come from a wider range, but in terms of research depth, they are far less deep than Spruce and the others.

But now, after genetic modification, Pang Xuelin's memory, learning ability, and thinking reaction speed are much higher than ordinary people.

And biology learning is not like mathematics, many things in biology are more biased towards memorization and experimentation.

Therefore, it is easier for Pang Xuelin to learn.

The only trouble is that biological theories are scattered and not very closely related to each other.

For example, the interaction between different protein molecules, non-transcribed RNA molecules, physiological functions, etc., are all independent systems.

Moreover, there are tens of thousands of protein molecules and RNA molecules. Even in the human body, there are still many life phenomena that have not been discovered or cannot be explained by existing theories.

For example, why can a DNA molecule only replicate once in a cycle?

How does the conformation of the DNA molecule affect the expression of genes?

What is the intrinsic relationship between the dynamics of proteins and their functions?

How do gene regulatory networks cope with noise?

How the nuclear genome is coordinated with the extranuclear genome and so on.

...

The lack of these theories can actually only further explain that human beings have a rather limited understanding of life.

And because the study time is relatively short and the coverage of biology is too wide, Pang Xuelin focused on the fields of virology, genetics, biochemistry, biophysics, molecular biology, computational biology and bioinformatics.

In less than half a year, Pang Xuelin's understanding of the T virus has far surpassed that of Spruce, Berkeley and others, not even Dr. Ashford, who has been immersed in the field of the T virus for decades. under.

In the past six months, under the leadership of Dr. Ashford and Pang Xuelin, [UUReading Book 00kxs], the Kempten base has conducted very in-depth research on the T virus.

Thanks to Alice's cooperation, Pang Xuelin and Ashford made an in-depth comparison of the evolution process of the T virus in the zombie body with that in Alice's body, and they found that the T virus in Alice's body turned into a endogenous retroviruses.

The so-called endogenous retrovirus starts with the pathogenicity of the virus.

Viruses are the smallest living organisms discovered by humans so far. They have no cell structure and must rely on the host cells they infect to provide the materials and energy they need to complete life activities.

So far, diseases such as AIDS, rabies, bird flu, influenza A, SARS, new coronavirus, smallpox, Ebola, etc. are all caused by viruses.

Therefore, in the minds of many people, viruses are always associated with disease and death.

But in reality, not all viruses cause disease.

Among the viruses that infect the human body, some viruses do not cause obvious damage to the infected cells or organs after entering the host cell.

Some viruses can coexist with host cells for a long time without incident, without affecting the daily life activities of the host, and some viruses can even benefit the host by giving it the ability to cope with environmental stress.

Take adeno-associated virus (AAV), which infects the vast majority of people without causing any disease.

Adeno-associated virus replicates and reproduces in the human body, but it does not affect the daily life activities of the host cells.

It is precisely by virtue of such characteristics that scientists have removed the coding part of AAV to construct a recombinant AAV virus vector. The recombinant vector can insert some therapeutic genes and introduce them into the human body through AAV, so that they can be stably expressed in the human body for a long time , and then treat some genetic diseases or cancer.

As for the other, it is the so-called endogenous retrovirus (ERV).

This virus has formed a very close relationship with human cells during the evolution process. It can be said that the normal operation of the human body cannot do without the help of ERV.

After analyzing the whole human genome sequence, scientists found that at least eight percent of the sequence in the human genome is derived from ERV.

Studies have shown that there are 1,743 genes in the human body that start or stop transcription from the ERV promoter sequence, and some ERV promoter sequences can even determine that their downstream genes can only be expressed in certain tissues or organs. time period to express.

Because of this, to some extent, ERV sequences can affect gene expression in the human body to a large extent, and thus have a very significant impact on the regulation and evolution of the human genome.

...

This evening, the underground laboratory.

"Professor Pang, the genetic test report on you is out."

Xiao Dongbei came out of the laboratory excitedly, waving a report in his hand.

"Take it here and have a look."

Before Pang Xuelin could speak, Ashford, Spruce and the others were impatient.

Previously, they had completed genetic testing on Alice, and found that part of the T virus in Alice's body had been transformed into an ERV sequence.

This is also the reason why Alice didn't become a zombie after being infected with the T virus.

The T virus transformed into the ERV sequence strengthened the life activities of Alice's cells, and at the same time, it did not make the cells out of control like zombies, but greatly improved Alice's body functions.

This is why Alice is like Superman.

After completing the detection of Alice, Ashford and the others began to turn their attention to Pang Xuelin.

They couldn't wait to see what happened to the T virus in Pang Xuelin's body.

The test report fell into Ashford's hands immediately, but after carefully reading it from beginning to end, Ashford couldn't help frowning deeply.

Afterwards, he handed the test report to Spruce who was at the side. After reading it, Spruce handed it to Berkeley, and then transferred it from Berkeley to Huang Yu. Finally, the report appeared in the Pang Xuelin's hands.

Pang Xuelin skimmed through the report, and at the same time he was a little disappointed, he was relieved, and he said lightly: "What do you think of this report?"

The report showed that Pang Xuelin was not infected with T virus, and even the ERV sequence homologous to T virus was not detected.

In this case, even on the side of the umbrella company, it would be difficult to find the specific formula of the gene optimizer through Pang Xuelin's genetic analysis.

Ashford asked curiously, "Professor Pang, isn't the virus you injected yourself in the hive laboratory a T virus?"

Pang Xuelin shook his head and said: "To be honest, the situation was urgent at that time, and I just thought of injecting that mutated T virus into my body temporarily. As for the sequence of that virus, I didn't have time to test it at all."

Ashford frowned slightly, and said: "You and Alice should be infected with two completely different viruses. The T virus was transformed into an ERV sequence in Alice's body, but what did it become in your body? It is difficult for us to figure out the gene sequence of the virus, unless a large-scale sequencing analysis of your gene is carried out, but the workload in it..."

Ashford smiled wryly.

Even the umbrella company has limited research on human genes, so what if all the gene sequences in Pang Xuelin's body were tested?

I don't know which part of the gene is working, but it's still versatile.

As for transcribing these genes one by one, conduct cell experiments to find out the functional gene fragments.

This is basically impossible.

The workload here is too huge, even if the umbrella company is given a hundred years, it may not be able to complete this kind of work.

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