I Have A Super USB Drive

After arranging the filming plan, Chen Chen came to the "Alzheimer's Disease Reversal Treatment" project team and asked for all the research results of the current project team, as well as a few mice.

The "Alzheimer's Disease Reversal Treatment" project team does exist. The leader is another neurology professor invited by Chen Chen, Evans, who has participated in several clinical trials of Alzheimer's disease. It's his old job.

However, Chen Chen did not intend to experiment with Evans, because Chen Chen needed to use NZT-48 for experiments.

Chen Chen would not tolerate NZT-48 being known to any outsider until his power completely surpassed the ordinary.

Therefore, Chen Chen could only carry out the experiment alone.

As for the mice asked by the project team, it is a genetically modified mouse carrying a mutant form of human tau. This mouse starts to develop tau tangles in the brain at 6 months of age, and at 9 Shows signs of neurological damage at the age of three months.

This is a human-made transgenic mouse that resembles a model of Alzheimer's symptoms.

Chen Chen reopened a laboratory on the 5th floor. After moving all these materials in, he began to watch Professor Evans' research results one by one.

Foreign academic circles have been adhering to the tradition of who discovered and named after whom. More than 100 years ago, a doctor named Alzheimer's dissected the brain of a patient who died of Alzheimer's disease and found a shocking discovery. Phenomenon.

The brain of the deceased is not only severely atrophied, but even the cerebral cortex, which is in charge of memory, thinking and language functions, is completely scrapped, replaced by necrotic brain cells and abnormal and strange brain deposits...

From this day on, human beings have officially fought against Alzheimer's disease, the disease of the century.

However, because of the hidden nature of Alzheimer's disease, people did not pay attention to this disease at first. It was not until the last 20 to 30 years that human lifespan has become longer and more patients with Alzheimer's disease have been diagnosed. The medical community has taken it seriously.

However, with the in-depth investigation of human beings, it is found that Alzheimer's disease is far more terrifying than human imagination...

According to the statistics of the Earth Federation Pharmaceutical Research and Development Association, from 1998 to 2017, top pharmaceutical groups including Bayer, Eli Lilly, GlaxoSmithKline, Merck, and Pfizer invested more than $600 billion in Alzheimer's disease that failed the test. The drug totaled 146 times.

Counting 2018 and 2019, in the past 20 years, the world's top scientists have failed 154 times in the face of Alzheimer's disease.

One of the most shocking is in January 2018, the world's largest pharmaceutical company Pfizer issued a statement: Due to insufficient technical capabilities, the research and development of Alzheimer's disease and Parkinson's disease drugs will be suspended...

In the face of this century disease, the world's top medical forces are at a loss.

Chen Chen looked calm, and ran his fingers over the stacks of documents. These paper documents were all held in folders. One book was five centimeters thick. At this time, the stack was as high as a hill in front of Chen Chen.

However, as Chen Chen flipped through the books, within a few hours, the materials beside him dwindled by half, and the piles of materials that he had read were accumulating higher and thicker.

If someone were to observe closely at this time, they would find that the more information they read, the brighter Chen Chen's eyes became, and finally seemed to be able to shine in the dark!

After reading the latest experimental data, Chen Chen finally exhaled, turned on the computer again, and compared it with the most cutting-edge results on the Internet.

After reading these, Chen Chen thoughtfully closed the page.

Well, the direction is already there.

There was a smile on the corner of Chen Chen's mouth, then he took out a finger-sized piece of chocolate, peeled off the tin foil, and stuffed the whole into his mouth.

NZT-48 can make the brain work at a high speed, but it also consumes a lot of fat, carbohydrates, and protein, and chocolate can make up for these substances. At the same time, theobromine can also increase the nervous system and help increase the oxygen content of the blood.

Therefore, Chen Chen recently developed the habit of eating a few pieces of chocolate after taking the medicine.

As the chocolate slowly melted in his mouth, Chen Chen also started his own experiment.

He first put on a sterile suit and sterilized his whole body, and then put on disposable rubber gloves in the laboratory, took out a capsule of NZT-48, and slowly dissolved it in glucose.

At the same time, Chen Chen took out the mice with the most obvious signs of nervous system damage, poured them an equal proportion of NZT-48 solution according to the grouping method, and then put them into each observation cage.

This is just one of the experiments.

In addition to testing the efficacy of NZT-48 on Alzheimer's disease, Chen Chen is also conducting another experiment at the same time, but different from the experimental direction on the market today, Chen Chen intends to conduct research on inflammation.

You know, science and technology now generally believe that the cause of Alzheimer's disease is "beta amyloid deposition" and "abnormal phosphorylation of Tau protein", so scientists put forward the hypothesis of the cause of Alzheimer's disease - beta amyloid theory.

Most current clinical trials target amyloid beta in an attempt to break down or prevent the formation of amyloid beta deposits.

But as I said before, all the therapeutic experiments targeting amyloid beta in the world have all failed.

So Chen Chen decided to start with the inflammation hypothesis and brain immune cells.

There are several hypotheses about Alzheimer's disease, including this inflammatory hypothesis, a 2018 study in the journal Neurology found the presence of the herpes virus in the brains of Alzheimer's patients.

Then in 2019, a team published a paper in the sub-journal of Science. They found Porphyromonas gingivalis in the brain of patients, and through mouse experiments, the bacteria invaded the brain of mice, and after the mice died , they found dead neurons and increased levels of beta amyloid in the brains of mice.

At the end of 2019, in the journal PNAS, a team found that in the brains of patients, a protein called TOM1, which is a crucial substance in a type of inflammatory response, was drastically reduced.

After the expression of TOM1 decreased, the β-amyloid protein in the mouse brain increased significantly, and these mice also experienced cognitive decline, and by reversely increasing TOM1, the cognitive ability of the mice was restored. recover.

This is the latest research achievement of the inflammation hypothesis, and even Professor Evans is also working in this direction.

In addition to the direction of the inflammation hypothesis, Chen Chen also added the hypothesis of immune cell deficiency.

Because a hallmark of Alzheimer's disease is the formation of "beta deposits" and "Tau tangles" in the brain, immune cells called microglia protect the brain by clearing these deposits and tangles.

They surround these noxious substances, engulfing deposits and tangles piece by piece.

However, the latest research has found that although microglia limit the accumulation of harmful substances, it may be a double-edged sword.

Because microglia can secrete a substance called ApoE, which in turn enhances the formation of beta deposits, and in later stages of the disease, once tau tangles have formed, microglia attack tangles that may harm nearby tau tangles. neurons, leading to neurodegeneration.

The study found that without microglia, or microglia were not activated, tau tangles and beta deposits would not accumulate and develop to an advanced stage, and the nervous system would not be damaged...

This is Chen Chen's research direction. With these directions, even if Chen Chen is still unable to cure Alzheimer's disease, he can at least limit the deterioration of the disease and lock this century-old disease in the early stage!