I Have A Super USB Drive

two months later.

Chen Chen stood quietly in the laboratory, his face pale.

In front of him, a white mouse was constantly swimming in an orris water maze.

This little guinea pig swims extremely flexibly. Although it looks a little confused, it always finds the right path quickly after wrong attempts, and finally finds the platform hidden under water.

No one could tell that these mice had been showing signs of severe neurological damage two weeks earlier.

Watching the No. 5 experimental mouse come to the platform, Chen Chen gently pressed the timer and said with a blank face, "28 seconds, 2 seconds faster than yesterday."

Afterwards, Chen Chen began to fill in the experimental records:

"6-month-old genetically modified model mice were treated with surgically transplanted cloned neural stem cells, and at the same time, they were treated with the myeloid trigger receptor 2 (tre2) agonist interleukin-4 (il-4) and induced microglial activation."

"Immunohistochemistry, Western blotting, and fluorescent quantitative PCR were used to detect tre2 expression from both protein and gene levels."

"The water maze experiment showed that the model mice showed cognitive function recovery in the water maze experiment."

"In this model, after il-4 treatment, the expression of tre2 was increased, and the memory and cognitive impairment of the model mice was greatly improved."

"Results: Tre2 activation may promote decreased autophagy in microglial cells through an inflammatory response."

Afterwards, Chen Chen bent down, caught the mouse that was resting on the platform, wiped it dry, fixed it on the CT machine, and fixed the brain in a state where it couldn't turn.

Then, Chen Chen started the machine, and the CT machine began to scan the brain structure of No. 5.

Comparing the new ct with the previous picture, I saw that on the picture, the brain structure of the mouse is much fuller than last week, and there are huge changes compared to two weeks ago.

If two weeks ago, the brain of the mouse was like a shriveled walnut, now it has become much fuller, like a puffed dough.

Arranging all the data into the corresponding categories, Chen Chen looked at the remaining mice in the experimental cage with the same performance, and covered the experimental cage.

Then, Chen Chen turned around and held the head of the No. 5 guinea pig. At the same time, he held the base of the guinea pig's tail with his right hand and pulled it gently.

Click!

There was a crisp click, and No. 5 in his hand died of a rapid and effective cervical dislocation.

Chen Chen put the mouse on the dissection table and began to dissect its brain.

Ten minutes later, No. 5's brain was completely isolated, but only then did Chen Chen realize that the mouse's brain had not recovered well.

Because of the large number of neuron death caused by Alzheimer's, the areas where these nerve cells died produce many connective tissue blocks, which occupy the original space of the brain and prevent the brain from returning to its previous state.

"Pity.

"

Chen Chen shook his head and soaked the brains in a solution filled with formalin.

In the past three months, Chen Chen has cloned this group of mice by cloning as usual. At the same time, he has used compound therapy in these mouse models with Alzheimer's disease.

1. Use the gene overexpression method of to1 protein to improve the brain's resistance to inflammation and gradually eliminate inflammation.

2. Use the nezuab antibody developed by Eli Lilly to remove aβ protein and amyloid deposits in the brain.

Although the drug failed several clinical trials and proved unable to treat Alzheimer's disease, its ability to clear the aβ protein is still worthy of recognition.

3. By injecting neural stem cells extracted from cloned embryos, and using cytokines to activate the g2 quiescent stem cells that originally existed in the brain, stimulate the brain to heal itself.

There is also the last item, that is, in the early stage of Alzheimer's disease, microglia are first activated to actively phagocytose abnormally deposited proteins.

However, if Alzheimer's disease has entered the middle or late stage, the opposite method is used to inhibit the activation of microglia until the use of nezuab antibody to remove most of the Aβ deposits and then activate the microglia.

This is the method taken by Chen Chen. Through the treatment of inflammation, the transplantation of neural stem cells, and the intervention of the brain's own immune system, this compound method can completely suppress Alzheimer's disease in the early and middle stages, allowing its Can't get worse, or even get better.

In fact, the real medical world is not unable to achieve the effect of Chen Chen. The only limitation is still cloning. Apart from this limitation, cost is also a factor that restricts this kind of treatment.

After all, the cost of this treatment plan alone is sky-high. If it is used commercially, a course of treatment will cost millions of dollars.

As for the steric hindrance effect caused by the death of a large number of neurons, and the fact that connective tissue occupies the brain, Chen Chen was helpless. Perhaps it would be a good way to remove the connective tissue through craniotomy.

As for nzt-48, due to lack of time and no actual progress, Chen Chen stopped the experiment.

Now that the nzt-48 experiment was stopped, Chen Chen started beckoning his assistants and assigned some less important tasks, which was how he got these experimental results so quickly.

Now that the experiment came to fruition, Chen Chen no longer hesitated and asked his assistant to bring in the old chimpanzee he had prepared earlier.

The scientific community has long discovered that chimpanzees can also suffer from Alzheimer's disease like humans, so before the mouse experiment was completed, they asked their assistants to make chimpanzee Alzheimer's disease models and clone these chimpanzees. .

This also saves a lot of time.

Not only that, Chen Chen also asked one person from the team protecting his parents in Zhongzhou District to go to Shangdu to secretly extract Professor Wang Xi's somatic cells and bring them back to clone Professor Wang Xi. After a few months, Professor Wang Xi really The cloned neural stem cells are immediately available upon arrival at the research center.

Such hard work is a kind of reward to Professor Wang Xi.

Thinking of this, Chen Chen was just about to carry out the next experiment when the phone rang.

Chen Chen frowned, picked up his phone and looked at it, only to realize that it was the call from the screenwriter in charge of the new movie.

Leaving the lab to his assistant, Chen Chen walked out of the lab and answered the phone.

"Modified? I know, I'll check it later."

It turned out that the screenwriter had once again revised the script according to Chen Chen's request and brought it to Chen Chen's review.

This is the task that Chen Chen entrusted to the Edwards family.

When I came to my office, I didn't need to ask, Xiao X had already opened the mailbox and projected the script sent by the other party on the wall.

Chen Chen spent a few minutes reading the entire script, and then nodded reluctantly.

The story background of the script was set 3 years after the reality, which was what Chen Chen requested. After all, the USB flash drive only accepts movies that are close to the reality structure. It is safer to set it directly as the reality background.

The main line of the story is that a little-known pharmaceutical company in North America, a researcher named Alexander suddenly discovered a small chemical molecule that can completely inhibit Alzheimer's disease.

This small molecule not only blocks tau tangles and prevents Aβ deposition, but also eliminates inflammation and completely ends all symptoms of Alzheimer's disease.

This drug is at the heart of the story.

The plot is that an unknown underworld force got the news from nowhere. In order to get drug samples, they started to kidnap the colleagues around the protagonist.

This script has been passed by Chen Chen several times before. In desperation, the screenwriter removed some parts of the film that were technically and logically unreasonable, although these parts were very dramatic and had a lot of selling points.

But this time, it almost met Chen Chen's expectations.

It's a pity that Chen Chen didn't expect Hollywood's speed to be so slow. It took two months from script writing to revision, and it was impossible to make the movie out of the movie no matter how fast the remaining month was.

Fortunately, Chen Chen has already found a cure for Alzheimer's disease. As long as it is successful in chimpanzees, Chen Chen can enter clinical trials.

Thinking of this, Chen Chen, the investor, replied "Pass" to the other party.   In this way, the movies on the Hollywood side can officially start.