Military Technology

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"In addition, these special cell preservation solutions can keep the cells to be printed at a low temperature, keeping the entire cells in a state of dormancy and extremely low activity. This will help extend the storage period of these cells and provide a better environment for future generations. 3D printing buys time.

Of course, there are pros and cons to using liquids to preserve and transport cells. The biggest drawback is that the liquid adheres to these tiny cells. How to remove excess water from these cells before printing without damaging the cells is an extremely difficult problem. technical problems to be solved.

Furthermore, there are millions and millions of these cells to be printed. Among such a large base, there will inevitably be some outliers, such as necrotic cells, mutated cells, cells of the opposite sex, etc. How to eliminate these cells and prevent these bad cells from being printed into organ tissues is also an urgent technical problem that needs to be solved.

In the past, it was basically impossible to solve this problem. Now with the help of artificial intelligence systems, we can monitor the status of these cells at all times during the delivery process. And in time, tiny probes are used to accurately aspirate the bad cells mixed in these huge cell groups to ensure that the cells used for printing are all healthy cells. "

Having said this, Wu Hao took a breath and said with a smile, "After solving such a series of problems, the next step is the printing process. How to adhere these different cell combinations together is also a problem we need to solve.

Use hot melt stacking or light curing? "

Wu Hao smiled and shook his head, "Cells are alive. How to stack these cells together in an orderly manner, whether it is hot melt stacking or light curing, is obviously not suitable. This requires a new printing technology.

As we all know, our human wound healing generally requires several basic processes. The first is the acute inflammatory phase. The early changes in the wound include varying degrees of tissue necrosis and blood vessel rupture and bleeding, and an inflammatory reaction occurs within a few hours. As a result, congestion, serous exudation, and leukocyte migration occur, resulting in local redness and swelling. Subsequently, the fibrinogen in the blood and fluid oozing out of the wound quickly solidifies to form a clot, forming a scab on the surface, which serves to stop bleeding, isolate and protect the wound, and prevent infection.

Next, comes the cell growth period. After two or three days of wound contraction, the entire layer of skin and subcutaneous tissue at the edge of the wound moves toward the center, so the wound shrinks rapidly until it stops in about two weeks.

The proliferation of granulation tissue and scar formation begin approximately on the third day after the injury. Granulation tissue grows from the bottom and edges of the wound to fill it up. Fibroblasts start to produce collagen fibers from five to six days, and the formation of collagen fibers is very active in the next week, and then gradually slows down. As the number of collagen fibers increases, the scar formation process occurs, and the scar is completely formed about one month after the injury. Possibly due to local tension, the collagen fibers in the scar eventually become parallel to the skin surface.

Therefore, during the process of organ tissue printing, we also need to simulate the process of wound healing by applying and injecting a biogel based on collagen, which can evenly adhere these cells together and then be evenly absorbed by the cells. , there will be no residue.

In this way, through continuous printing, we obtain a complete biological 3D printed organ tissue that we want. "

"Simple, it seems very simple, but in fact there are still many problems that need to be solved. For example, we seem to have overlooked one problem, that is, where do the cells used for organ tissue printing come from?"

Hearing this question, all the people watching the live broadcast started to talk curiously, indeed. Where do these somatic cells for printing come from? There are many speculations. Some say that it is extracted directly from the patient, dissolved and isolated, some say that it is obtained from a donor, and some say that it is made by oneself.

Wu Hao smiled, and then replied, "There have always been differences within our scientific research team regarding the acquisition of cell sources. Some people believe that we should screen out a universal somatic cell group, and then through continuous cloning, cultivation and division, finally Form the specialized biological cells we need for printing.

But there will be a problem, that is, the printed organs and tissues are not the patient's own, and implantation into the patient's body will cause rejection. This requires patients to constantly take medication, and the lifespan of such organs is generally short, and the post-healing effect is average, making it impossible for patients to truly recover from health.

So other people think, why don’t we directly extract cell tissues from patients and then clone them. The organs and tissues printed using these cells will not cause rejection when implanted into the patient's body, and the recovery will be good, allowing the patient to basically return to normal life.

Finally, after constant discussion and research, we chose the second method. Although it is more difficult and technically demanding, it can cure patients better and bring health to them.

In this way, we have to solve the cloning technology of somatic cells. Again, the technology seems simple. After all, in everyone's perception, cloning technology seems to have been around decades ago, so there should be no problems.

However, the cloning technology that everyone knows is very different from the cloning technology we need. We cannot use the mother body for cultivation, which will bring about a series of social moral, ethical and legal problems. Therefore, we can only carry out in vitro cloning culture, which requires us to develop an 'artificial z-uterus' or 'artificial placenta'.

And this equipment must have sufficient performance, find Shuyuan www.zhaoshuyuaｎ. com can clone and culture enough cells in the shortest time.

As we all know, the condition of patients undergoing organ transplantation is generally critical, so there is not much time to wait. This requires us to control both cell cloning and biological 3D printing within a very short period of time.

However, cell division and reproduction, including cloning, take time. Special hormone drugs can speed up the cell division and growth time. However, doing so will also cause harm. The printed organs and tissues will also have problems, and implanting them into the patient's body will bring danger to the patient.

Therefore, a new cell cloning cultivation technology is needed, which can allow cells to divide and grow rapidly and healthily, so as to obtain enough cloned cells in the shortest time.

In order to develop this technology, we invested a lot of financial resources, manpower and material resources, and cooperated with famous domestic and international scientific research institutions, and the laboratory began a long road of scientific research and exploration.

We also invited relevant scientific research experts and hospital experts to conduct discussions and research, and finally obtained a set of feasible research plans. "