My Life Simulator

The so-called "major breakthrough", Lu Li was somewhat disapproving.

Even if the information transmission mechanism of T cells is blocked and the ability of T cells to call friendly forces is limited, the immune response is still very violent.

Treatments with stronger side effects than treatment effects are undoubtedly unsuccessful.

But... all the anti-cancer methods so far have side effects that are more severe than the treatment effects.

Commonly used radiation therapy, while radiation kills cancer cells, it kills more normal cells, and radiation is also carcinogenic, which is almost like drinking poison to quench thirst.

Chemotherapy is tougher! Completely kill one thousand enemies and lose three thousand.

As for the most cutting-edge CAR-T technology, the lethal effect is far greater than the therapeutic effect.

However... even if the side effects are so huge, there are still countless people who are rushing to get treatment.

Being terminally ill, watching life go by day by day, this kind of fear makes people not care about the side effects at all, even if there is only one in ten thousand, or even one in 100,000 hope, they should try.

Therefore, Lu Li actually underestimated his scientific research achievements.

...

Milliken.

In a ward of a private hospital, an old gentleman was lying on a hospital bed next to a doctor in a white coat.

"Doctor Henry, are you here today to tell me that there is no hope?"

On the old face, a pair of cloudy eyes revealed a deep unwillingness.

"No! Quite the contrary, sir!"

A smile appeared on Dr. Henry's face, "I brought you hope!"

"hope?"

There was a glint in the old gentleman's eyes, "This is the best news I have heard recently! So... where is my hope?"

"CAR-T Technology!"

Dr. Henry replied: "Sir, a few days ago, a Chinese scientist named Lu Li improved the CAR-T technology, which can greatly reduce the factor storm caused by the immune response. So... your hope has appeared!"

"Thank God!"

The old man reached out and made a cross on his chest.

"You should thank this Chinese scientist Lu Li!"

Dr. Henry thought to himself: God didn't save you, but... Lu Li's research results might be able to save you!

"Yes! Thank you Lu Li!"

There was a gleam of hope in the old man's eyes.

...

The same scene is happening in many parts of the world.

Lu Li's improved CAR-T technology, a gene editing technology that shields the information transmission mechanism of T cells, has brought a glimmer of hope to countless people in despair.

This new technology, which is still very immature and not even successful, will not save everyone's life.

Only those with weak immune responses or strong physical fitness who can withstand the immune response will gain vitality.

However...for people in despair, this little hope is what keeps them going.

In the next month, hundreds of cancer patients who survived because of Lu Li's new technology will appear around the world.

For a while, Lu Li and his T cell gene editing technology have received widespread attention from the medical community and have also had a huge impact on society.

"my country's young scientist Lu Li has opened a new chapter in the fight against cancer for mankind!"

"Lu Li invented a new technology for cancer treatment. It doesn't require radiotherapy, chemotherapy, or even surgery."

"Genes are the future. From Lu Li's T-cell gene editing technology, talk about the impact of genetic engineering on humans."

"How far are we from conquering cancer? Lu Li tells you that this day is just around the corner!"

News reports about Lu Li appeared everywhere in newspapers and on TV.

On the campus website of Fudan University, a floating news was posted: "Warm congratulations to Lu Li, a student from our school, who has achieved a major breakthrough in CAR-T technology!"

This upsurge of new anti-cancer technology has also spread to Xichuan and Yucheng.

When Xichuan TV and Yucheng TV learned that Lu Li was their own, the publicity became more lively.

"News from this station: Lu Li, a young Chinese scientist, has made major scientific research achievements in CAR-T anti-cancer technology, creating a new technology for cancer treatment."

"Lu Li, from Xichuan Yucheng..."

Mother Lu, who was selling vegetables in the vegetable market, raised her head in surprise and looked at the TV screen hanging on the wall.

Land from? my son?

My son turns out to be a scientist?

Lu's mother rubbed her eyes, looked at it for a while, and found that the photo that appeared on the TV was Lu Li, her son.

Some time ago, my son sent some money to his family, saying that he was going to Fudan for graduate school.

Now... turned into a scientist?

After standing blankly for a while, Mama Lu burst out laughing again, and then began to show off: "My son! This is my son! My son is a scientist!"

"Sister-in-law of the Lu family, your son is actually a scientist? That's amazing!"

"Yeah! Yeah! Scientists! It's amazing!"

The people around were full of admiration and admiration.

Afterwards, Mother Lu's food was given away again. Dad Lu called Peng Huoyou again to set a drink for the guests.

Uh...why do you say "again"?

...

"Little Lu, congratulations!"

Professor He put down the newspaper in his hand, and the front page of the newspaper was Lu Li's photo.

"thanks!"

Lu Li smiled and said, "CAR-T technology is still immature, and the praise from the outside world is a bit exaggerated."

"Don't underestimate yourself!"

Professor He smiled and said: "Your improved CAR-T technology is one of the most effective means of fighting cancer at present."

Speaking of which, Professor He glanced at Lu Li and continued: "You have achieved major scientific research results. I had a conversation with Dean Jiang, and we all felt that your knowledge level and scientific research ability have exceeded the level of a graduate student. . So, you can graduate."

"what?"

After only one year of graduate school, can you graduate early?

"Graduate students and doctoral students actually do not have strict time requirements for study. As long as your knowledge level and scientific research ability meet the standards, you can graduate."

Professor He explained with a smile, and then asked Lu Li, "After you get your master's degree, do you plan to study for a doctorate in that direction?"

"Of course I will continue to learn from you!"

Lu Li felt that the cooperation with Professor He was very pleasant, and he was too lazy to find another tutor. It would be more convenient to continue to study under Professor He.

"this……"

Professor He hesitated for a while and said, "Of course I'm very happy that you continue to study with me. But... your research direction is mainly genetics. I'm afraid I can't give you much help in this regard."

"Don't say that, I still have a lot to learn from you."

Lu Li has copied the knowledge of countless professors, and his knowledge accumulation is already very rich.

For Lu Li, what he needs is not the guidance of knowledge, but the convenience of scientific research.

Therefore, Professor He, who gets along very well, is the most suitable tutor.

"OK then!"

Seeing that Lu Li had a high willingness to continue his Ph.D. study with him, Professor He did not object, "You prepare. At the end of the semester, you will take the exam with the graduates of this class and prepare a graduation thesis."

"OK!"

Lu Li nodded in agreement.

After leaving Professor He's office, Lu Li returned to the Riverside Garden.

Sitting down in the study and turning on the computer, Lu Li was about to prepare his graduation thesis when he suddenly saw hundreds of emails appearing on his e-mail.

"Why are there so many emails?"

Lu Li hurriedly clicked on the email.

Some of these emails are exchange and discussion emails sent by scholars from various domestic research institutions and doctors from various tumor hospitals.

There are also some emails, which turned out to be cooperation invitation letters from various companies, and even invitation letters from biopharmaceutical companies.

The treatment is very high, but unfortunately Lu Lizhi is not here, and he doesn't need to hug the thigh of the "gold master's father", so he doesn't bother to care about it.

To Lu Li's surprise, there were also invitation letters from some research institutions around the world in the email, inviting Lu Li to exchange and discuss.

Among these invitations, there are exchange invitations from the American Society of Oncology.

"An invitation to exchange from the American Society of Oncology?"

A smile appeared on Lu Li's face, "Is this sent to the door for me to copy knowledge?"

In terms of cancer research, the American Society of Oncology does have a deep accumulation. These accumulations are also very valuable to Lu Li's technology to conquer cancer, and it is worth replicating.

It's just... Lu Li has no idea of ​​going to the United States to exchange ideas for the time being. Let's get a master's degree first!

After replying to some of the more important emails in the mailbox, and leaving other emails alone, Lu Li closed the email.

He got up and walked out of the study, lying on the sofa, Lu Li closed his eyes and opened the virtual laboratory again.

Graduation season is two months away.

Lu Li was not worried about the graduation exam at all. It's just that...the graduation thesis will take a lot of thought.

If you just deal with it, the graduation thesis is not difficult. However, Lu Li was known as a young scientist before, so naturally he couldn't fool a graduation thesis.

Let's continue to study from CAR-T technology!

Last time, by modifying the genes of T cells, Lu Li reduced the intensity of the immune response and reduced the chance of the human immune system going crazy.

This genetic modification is very safe. Because after T cells complete the task of killing the enemy, they will rapidly self-destruct and will not exist for a long time.

Now, what Lu Li wants to modify is another type of immune cell, dendritic cells.

Dendritic cells are intelligence agents in the immune system. They quickly transmit the information that the human body is attacked by viruses to the immune system, triggering a violent immune response in the human body.

Under normal circumstances, dendritic cells, an intelligence agent, are extremely beneficial to the human body. They are the key to the human body's defense against virus invasion.

However... In CAR-T technology, in order to prevent the immune system from going crazy, weakening or even shielding the intelligence capabilities of dendritic cells is more valuable for treatment.

However, dendritic cells exist for a long time and do not self-destruct. Once the intelligence ability of dendritic cells is modified, the immunity of the human body will be reduced.

This made Lu Li a little confused.

By modifying the genes of dendritic cells and weakening their intelligence, it may be possible to reduce the chances of the immune system going crazy and allow T cells to kill cancer cells smoothly.

However... in case the cancer is stabilized and will not deteriorate, but the patient died because of a cold, how can this make sense?

Experiment first!

Human experiments that cannot be done in reality can be done at will in the virtual laboratory without taking any risks at all, which is very convenient.

Next, Lu Li began to gene-edit the dendritic cells.

It is also used to cut the DNA chain of dendritic cells, shielding the "intelligence ability" of dendritic cells!

Experimentation is trial and error!

The advantages of the virtual laboratory are very obvious.

No consumption at all, no need to burn money at all, no matter how expensive the experiment is, it can be done openly.

One day, two days, one week, two weeks.

Lu Li did countless experiments and finally identified the "gene fragments" of dendritic cells that represent intelligence capabilities.

Once the target is found, it is easy to operate.

Transcriptase-labeled gene fragments were injected into dendritic cells together with the spliced ​​protein, and a dendritic cell that shielded the intelligence ability was successfully prepared.

And then... Lu Li started doing human experiments.

After injecting this dendritic cell, which shielded its intelligence ability, into the experimental body, Lu Li began to observe the reaction of the experimental body.

And then... no response.

After inspection, Lu Li found that the dendritic cells injected into the experimental human body did not divide or proliferate, and they were "quiet and beautiful men".

A dendritic cell without intelligence ability has no effect on the human body at all.

Is it necessary to modify all the dendritic cells in the human body?

There are 60 trillion cells in the human body, even if there are not many dendritic cells, it is calculated in billions. This workload... wait until the patient hangs up, and the dendritic cell modification task has not been completed.

This road is completely impassable!

Lu Li let out a long sigh, and sure enough, it wasn't that easy to handle.

wrong! I was thinking wrong!

Don't want to answer the phone, why would you want to toss and close down China Unicom? Can't you just turn it off?

So Lu Li set his sights on another type of immune cell.

B cells!

If T cells are frontline troops, B cells are logistics and command.

Since the intelligence ability of dendritic cells cannot be shielded, the B cells should be shut down and cannot receive the "phone" of dendritic cells.

B cells, the logistics and command center, cannot receive information from dendritic cells, so naturally they will not produce immune responses, and will not release immune factors, which will greatly reduce the madness of the human immune system.

More importantly, B cells, like T cells, will self-destruct after the battle, leaving only a very small number, which is stored in the lymph nodes. Most of the B cells will not exist in the human body for a long time.

So...modifying B cells is the right direction.

Thinking of this, Lu Li immediately started to act.

It took another month for Lu Li to identify the gene segments that B cells receive messages from.

This is where the hardest part of genetic modification comes in. Humans still know very little about genes. Three billion base pairs, it takes a long time to interpret all of them.

After finding out the gene segment of B cells that receive messages, Lu modified the genes of B cells with splicing proteins, blocking the ability to receive messages.

Finally, a genetically modified B cell was prepared!