My Life Simulator

After preparing this B cell, Lu Li immediately conducted human experiments.

This is again a huge advantage of virtual labs.

If it is a normal experimental procedure, experiments must be carried out on various small animals first, and after a long period of time, it is possible to carry out human experiments.

Even... many scientific research projects have no chance of being approved for human experiments at all.

Lu Li was different.

In the virtual laboratory, everything is virtual, and everything is fake. He can do human experiments at will, and he can do whatever he wants, without any restrictions at all.

Same this time.

Lu Li directly injected the modified B cells into the experimental human body.

And then... nothing happened.

Um? how come?

Lu Li was taken aback for a moment, then quickly picked up the testing equipment and carefully inspected the experimental human body.

Then, Lu Li found the reason!

The B cells that block the ability to receive information are also a "quiet and beautiful man"!

Without receiving any information, it returns to the lymph nodes with the lymph fluid, and stays there motionless, leisurely.

On the contrary, other B cells that exist in the human body, after receiving the information, reproduce frantically, release immune factors frantically, and cause the immune system to go crazy.

So...B-cell "shutdown" is also not acceptable!

How to do this?

Lu Li's head hurts a bit!

Forget it, take a break. For more than a month, I have stayed at home every day to do research, and everyone has rusted!

After closing the virtual lab, Lu Li got up and went out, went around the artificial lake in Binjiang Garden, and started running!

As he was running, Lu Li suddenly saw a girl in front of him doing morning exercises.

This girl is wearing a white tight-fitting sports suit, and her figure...that's really bulging.

Fortunately, Lu Li's will is as strong as steel, even when he sees such a sultry scene, his heart does not fluctuate.

I'm even thinking... The weight of the chest and hips is too large, which affects the coordination of the human body. This kind of body structure does not conform to the laws of nature. In the cruel natural competition, it will definitely be eliminated by natural selection!

The next moment, Lu Li thought again... Humans no longer need to suffer cruel natural selection! This body structure is more suitable for gene transmission.

So, what is going on in the mind of the scientific research dog?

Just when Lu Li was thinking about serious scientific issues, the sultry girl heard the footsteps behind her and turned her head to look over.

Seeing Lu Li's handsome face, slender and straight body, and strong muscles, this girl's eyes flashed with light, and a smile appeared on her face.

"Hi!"

The girl waved at Lu Li and took the initiative to say hello.

Uh... Because of my handsome appearance and my strong body, I am very suitable as a combination of genetic transmission, so under the control of genetic instinct, she took the initiative to greet me.

Sure enough, humans are just tools dominated by genes!

Love is only the instinct of gene transmission, family love is only the instinct to protect the continuation of genes, and human beings are only tools dominated by genes.

A series of scientific explanations popped up in his mind, but Lu Li responded with a smile, "Hi!"

Nothing else, mainly...too big!

It's still a genetic instinct!

"Do you live here too? Why haven't I seen you before?"

The girl slowed down and ran alongside Lu Li.

"Lived for over a year."

Lu Li replied and asked, "Do you live here too? I haven't seen you before!"

"Just came a few days ago!"

The girl smiled, "I used to be in Beijing. My sister lives here. I came to see my sister!"

"Oh! Beijing is a good place!"

Lu Li nodded, "I used to stay in the capital for a while."

That's in the plot. In the plot of the actor and the master of craftsmanship, Lu Li spent a long time in the capital.

"yes?"

The girl was running, sweating slightly on her fair face, and there was a strange beauty of jade plate rolling balls.

"My name is Wen Wan, how about you?"

The girl introduced herself, then turned her head and asked Lu Li.

"My name is Lu Li."

"Land from?"

Before Lu Li could finish speaking, Wen Wan exclaimed, "You are the one Lu Li who developed the new CAR-T technology? My God! I didn't expect to meet you here, what a coincidence!"

"I'm not so well-known yet, right?"

In today's society, people only pay attention to the lace news of celebrities, who cares about scientific research dogs?

"Introduce yourself. Wen Wan, a graduate student of basic medicine at Union Medical College."

Wen Wan smiled at Lu Li, "Boss, don't you know how famous you are? You are our idol!"

"Oh! It turns out to be a colleague!"

Lu Li nodded, "No wonder you know me."

"Boss, add a WeChat!"

Wen Wan took out her mobile phone from her sports wrist bag and raised it towards Lu Li.

"WeChat?"

Lu Li's footsteps stopped, and a light flashed in his mind.

Yes! WeChat!

My previous thinking was wrong!

Why shut down B cells? Why make B cells unable to receive information? I just need to make B cells unable to send "WeChat" and "Circle of Moments"!

B cells receive the information from dendritic cells, immediately activate the stress mechanism, and continue to divide and proliferate.

And then... After these genetic modifications, B cells that "can't send WeChat" and "can't send friends circle" have largely occupied the positions of other normal B cells, and then "dead meal", nothing!

In this way, the chance of immune factor outbreaks will be greatly reduced!

"Ha ha ha ha!"

Lu Li laughed loudly, turned around and ran away without a trace.

Behind her, the gentle girl's face was sluggish!

what does it mean? I asked you for a WeChat, is it so funny?

Also, what do you mean by running away like this?

Are all scientific research dogs such straight men? You deserve it to die!

The gentle girl stomped her feet heavily, her face full of depression!

...

Lu Li was suddenly enlightened and found a breakthrough. How could he care about any girl?

He ran home in a swipe, and regardless of the sweat on his body, Lu Li lay down on the sofa, closed his eyes, and opened the virtual lab again.

"Virtually an experimental human body with advanced cancer!"

When he came to the virtual laboratory, Lu Li gave the order directly, changed into a white coat in a hurry, and walked into the operating room.

Taking specimens from the experimental human body, and picking up several specimens containing cancer cells, T cells and B cells, Lu Li hurriedly sat in front of the test bench and continued the experiment.

First, the CAR-T experiment was performed to prepare the required T cells, and Lu Li took out the B cell samples and began to genetically modify the B cells.

The direction was right, and the experiment went smoothly.

Lu Li modified the genes of B cells with splicing proteins, blocking the ability of B cells to transmit information to the outside world.

Then... Lu Li picked up the B cells and injected them into the experimental body. Then, using CAR-T technology, gene-edited T cells were also injected into it.

The next moment...a miracle is born!

The "hostile sequence" of T cells discovered the cancer cells in the experimental human body, and immediately stimulated the immune mechanism, divided and proliferated frantically, and launched a violent attack on the cancer cells.

At this time, the T-cell army was dispatched, and the "intelligence" dendritic cells were aware of it, and quickly sent information to the B-cells, kept calling for reinforcements, and kept reporting the news of the "breakout of war".

Normal B cells are activated and immediately divide and proliferate. However... the B cells whose genes had been modified by Lu Li were also proliferating violently.

As a result, many B cells of the "corpse meal" occupy the positions of logistics and command. Their inaction makes the immune mechanism work significantly slower.

The "immune factor storm" did not break out on a large scale, nor did it cause the immune system to go crazy.

Although the experimental body still had a fever and the immune response was still intense, the immune system did not attack the vital organs indiscriminately, and it did not lead to heart failure, lung failure, and other internal organ failures.

The experiment was a success!

Lu Li laughed.

This sense of pleasure in overcoming a scientific research problem and the sense of achievement of this technological breakthrough made Lu Xin very happy!

From a certain perspective, CAR-T technology already has clinical value!

It reduces the immune response, avoids the immune factor storm, and prevents the immune system from attacking the human body indiscriminately, but it can accurately kill cancer cells. This is the best way to treat cancer.

But...it's still not a complete cure.

Once T cells kill cancer cells in the body, they self-destruct and do not persist in the body for long.

And then...after a period of time, maybe three years, maybe five years, or ten years, the cancer cells will reappear.

A person who has had cancer has the genes of cancer cells imprinted in his DNA, and recurrence is inevitable!

Of course, after relapse, CAR-T technology can still be used for treatment!

However, this presents a new problem. Cancer cells are likely to have new mutations in the battle against T cells, and are likely to have the ability to resist T cell attacks.

Just as viruses mutate constantly, it is almost inevitable that cancer cells will evolve and mutate.

So... although Lu Li has come up with the best treatment for cancer, he still hasn't conquered cancer fundamentally!

Lu Li was still not satisfied with his research results.

...

After closing the virtual lab, Lu Li took a shower, changed his clothes, sat down at the computer desk again, and started writing his thesis.

"The application of gene editing technology for T cells and B cells in CAR-T technology."

Lu Li put forward a new theory, based on the modification of T cells' "friend or foe identification system" and "call friendly force" capabilities, he further proposed a plan to shield the B cell's command ability.

This is a mature technology that is ready for clinical application.

Papers are open to the world. In this paper, Lu Li only expressed theoretically, and did not express experimental data and specific operation methods.

Immature technologies can be made public. Mature technology, it must be kept secret.

After writing this purely theoretical paper, Lu Li wrote a detailed experimental report, which stated the experimental data and experimental steps.

This experimental report, Lu Li is going to hand over to Fudan Medical College. As for how the above is going to deal with this scientific research result, that is what the leaders consider!

After writing the thesis and the experimental report respectively, Lu Li took the test with a USB flash drive and hurried to Fudan Medical College.

"Little Lu, are you here?"

Seeing Lu Li's arrival, Professor He smiled and said hello, "Are you... submitting your graduation thesis?"

"Um!"

Lu Li nodded, "Teacher, I wrote a paper, which is still a paper on CAR-T technology. Take a look."

After speaking, Lu Li took out the USB flash drive and copied the papers and experimental reports into Professor He's computer.

"I have to take a good look at your graduation thesis!"

Professor He reached out and picked up the mouse, and clicked on Lu Li's paper.

"The application of gene editing technology for T cells and B cells in CAR-T technology?"

Seeing this title, Professor He was shocked, turned his head to look at Lu Li, and asked repeatedly, "App? You mean App? Are you sure?"

Applying this word is not something that can be written casually. Dare to say "application", it is a mature technology!

Is CAR-T technology mature enough to be applied?

Is Lu Li telling me that he has conquered cancer?

Professor He took a deep breath, only to feel that his heart was about to burst.

"I think this technology has matured. Take a look first!"

Lu Li has already done human experiments. Although it is a virtual human experiment, it is no different from a real human experiment.

This technology has been proven!

"Okay! I'll take a look first!"

Professor He took a sip from the teacup, trying to suppress the shock and excitement in his heart, but...the hand holding the teacup was shaking!

After making up his mind, Professor He opened the thesis and read it carefully, word by word, from beginning to end.

After reading it this time, Professor He almost knocked over the teacup!

Modify T cells to target cancer cell genetic characteristics. This step is the technology disclosed by CAR-T, and people all over the world who study this project know this step.

Then in the second step, Lu Li made modifications on the T cells to block the information transmission mechanism of the T cells, so that the T cells would no longer "call friendly forces".

This step has been disclosed by Lu Li in the last paper, and it has also been verified by major scientific research institutions around the world. It is even the best way for countless cancer hospitals to treat patients with advanced cancer.

Now, in this paper, Lu Li gives the third step, which is to perform gene editing and modification on B cells, shield the command ability of B cells, and make it no longer frantically release immune factors.

Theoretically, this is a feasible solution.

After closing the paper, Professor He opened the experimental report next to it.

In the experimental report, Lu Li described all the operation steps in detail and wrote all the experimental data.

This experimental report is very detailed, and it is completely possible to repeat the experiment according to the experimental report.

Of course, Lu Li did not write down the data of the human experiment. After all, it is not that easy to do human experiments in reality.

After reading the paper and the experimental report, Professor He raised his eyes to look at Lu Li, his expression still a little dull.

"So...the cancer has been conquered by you?"

After being sluggish for a while, Professor He suddenly burst out laughing: "Hahahaha! My student has conquered cancer!"

"This is a great scientific research achievement! From today, cancer is no longer a nightmare for mankind!"