Rebirth of the God-level Xueba

"Huh, crystal structure diagram?" Marjorie is a professor of biology at the Karolinska School of Medicine, and he is not very sensitive to words such as g-protein coupled receptors.

What the professors at the Karolinska Institutet do the most is to read the literature, especially the literature of scholars who are eligible to win the Nobel Prize.

For them, the Nobel Prize is both an advantage and a burden.

The advantage is that the Karolinska Institute of Medicine has received a lot of funding and the attention of high-end scholars from abroad, but the burden is the constant reading of literature.

Professors at the Karolinska Institutet read literature differently from ordinary scholars. Normal people read literature for what they need. For example, if Yang Rui wants to read literature, he basically focuses on G-protein coupled receptors, PCR, and genes. , Genetics and other fields, all in all, you need to read what you need, other fields are usually limited to understanding, at most read a few articles, just know it.

Professors at the Karolinska Institute can’t read the literature like this. They have to read the S-level papers to the end, regardless of whether they are in their own field or not, they must read them all, especially scholars who may win the Nobel Prize. There are also fields that are likely to win Nobel Prizes, all of which have to be counted.

A person's time is limited, and a scholar's time is even more so.

Nowadays, in some hot fields, there are three or five laboratories working on them. The professors of the Karolinska School of Medicine spend most of their time reading literature that has nothing to do with their own research. The investment in scientific research itself is One can imagine.

For Marjoli, he has gradually become tired of being a professor at the Karolinska Institutet, but the foundation laid over the years is still there.

He was the first to wake up when he heard the words "g protein-coupled receptor" and "crystal structure diagram", and hurried to the laboratory.

To be honest, if Yang Rui hadn't said it, he wouldn't have believed it.

As professors of biology at the Karolinska Institutet, the most basic ability of Marjoli and the others is to judge an academic direction, how long it takes to see the light of day, and how long it takes to see the results.

Of course, such a judgment is definitely inaccurate, but there is also a certain range.

Yang Rui's ion channel laboratory has just completed the clear structure of g-protein coupled receptors - a few months is just now for Wang's scientific research results - Marjoli believes that the basic time for obtaining the crystal structure diagram is also It should be more than three years, but less than two years.

This kind of judgment is not a joke. Whether a laboratory should spend tens of millions of dollars to join such competition is often made according to this judgment:

It is expected that the crystal structure of g protein-coupled receptors will be revealed in the next two to five years. According to the capabilities of our laboratory, we may complete the project in the next two to four years. There is a certain chance of winning if we join the relevant competition. Consider joining the competition.

The Ion Channel Laboratory of Peking University completed the crystal structure of the g protein-coupled receptor within a few months, which means that other laboratories all over the world participating in this project have suffered a huge loss.

At the same time, it also means that the resources of the whole society have been saved a lot.

However, Marjoli is not concerned about the saving part. He can't help but feel nervous when he thinks of the laboratory that is working on related projects.

The reactions of the others were a bit slower, but they all opened their eyes wide one after another, and hurriedly asked: "You made a clear crystal structure diagram? So fast?"

"We actually completed the relevant research a few months ago, but it took a relatively long time to repeat the experiment." Yang Rui let everyone into the laboratory while talking.

Doing repeated experiments in a few months is actually not much at all. Some verification experiments are laborious to do, and some take several years.

However, Yang Rui's words fell on the ears of those who cared, but they were as terrifying as thunder.

I started doing repeated experiments a few months ago, when did I get the results?

Do you dare to say that in recent months, many laboratories around the world have been doing nothing?

Marjorie felt cruel just thinking about it.

However,

The world of scientific research is so cruel. Those who feel cruel will die in the boundless competition, and those who survive can only grit their teeth and persevere.

"Let me take a look at the results of your work." Marjorie offered to ask.

Yang Rui smiled and said: "What you see now is the result of repeated experiments. In addition, our paper has also been written."

Papers are sorted and sublimated experimental records, so they are naturally most suitable for reading.

Marjorie didn't say much, took it and started to read it quickly.

Lancerot, who was behind him, also came from Katherine Medical College, took a thick paper slowly, and read it quietly.

Such papers are time-consuming to read. Generally speaking, Marjoli is used to skipping.

But this time, he was a little reluctant.

This is a king-level scientific research project.

Papers of king-level scientific research projects, what a waste if you don't read them carefully.

Yang Rui was not in a hurry, he asked someone to make tea for them, and then sat on the side.

After drinking a few cups of tea, Marjorie finally raised his head and said, "Director Yang, can we have a chat with the researcher who did the actual operation?"

"Of course." Yang Rui responded to every request.

Today is to show off skills, but he hesitated a moment when he stood up, and shouted: "Gu Qiang, how is your memory going?"

"It's over." Gu Qiang replied in a low voice.

"Then come here, Su Xiankai, Fan Zhenlong...you all come here too." Yang Rui called several people's names one after another.

"I see the name of Researcher Gu Qiang in the paper." Majoli got used to it naturally, and immediately began to trace the person who completed the experiment, and asked, "Researcher Gu Qiang, is it convenient to introduce the experiment process?"

Gu Qiang said obediently: "I formed the complex in the presence of detergent? We named this complex the args complex. After testing, I found that it can effectively form the complex in the phospholipid bilayer. The coupling of..."

"Wait, it is necessary to use a detergent. Why do you need to form a complex in the presence of a detergent?" Marjoli had doubts in the first sentence.

Gu Qiang looked at Yang Rui, did not get an answer, shrugged, and said: "Because to ensure the purity of g protein, we must remove the detergent. We want a pure complex, and naturally it can only be obtained under the condition of the presence of detergent. conduct."

"Even if the coupling efficiency is greatly reduced?"

"Of course." Gu Qiang had also studied this issue before.

However, Marjoli had read much more literature than Gu Qiang, and immediately raised a question: "Have you not considered changing the method? For example, instead of detergent, use physical or other methods to ensure g As for the purity of the protein, I have seen that many laboratories are making attempts in this area. How do you make a judgment?"

Gu Qiang opened his mouth, but didn't know how to answer.

He actually never thought about it.

The experimental plan Yang Rui gave him was to synthesize it in the presence of detergents. Gu Qiang's theoretical system was weak, and he never considered bypassing this point.

Of course, it was also his experiment that was done too quickly, and he quickly broke through this difficulty.

However, Marjoli's question is also very typical, Gu Qiang thought for a moment, and said honestly: "That was my task at the time."

"You mean, Mr. Yang Rui arranged your plan?"

"Yes."

Ma Joli turned to Yang Rui naturally, and asked, "Mr. Yang Rui, what did you think about at that time?"

"I didn't think about it."

"kindness?"

"I arranged for other people to try other solutions." Yang Rui said calmly: "Our investment in g protein-coupled receptors is still relatively large."

Marjorie immediately understood, and said, "Do you have multiple groups doing experiments?"

"Of course. Su Xiankai and Fan Zhenlong were in different groups at the time." Yang Rui answered in the most concise way.

That's how it is.

As the person in charge of the laboratory, Yang Rui proposed a plan and arranged for different researchers to do verification. This is the most basic laboratory operation plan.

This is like Yang Rui leading a march. When encountering a fork in the road, he can of course decide where to go based on experience and theory, but he can also send people to explore directly.

Gu Qiang was lucky enough to find the right direction, that's all.

With a few simple words, Marjorie had a clear idea.

He asked Gu Qiang a few more questions, and slowly changed the topic to Yang Rui.

Academic achievements are attributed to IQ and distributed according to IQ. Hard work itself is worthless.

Yang Rui asked and answered, and quickly established a corresponding image in the hearts of everyone.

With the deepening of the problem, some scholars began to lose track of the dialogue between Marjoli and Yang Rui, and most of them began to focus their thoughts on the project itself.

"The Ion Channel Laboratory of Peking University analyzed the crystal structure of g protein-coupled receptors."

"Yang Rui's research is advancing so fast."

"incredible."

The whispered discussion of a few people gradually turned into a discussion among a group of people.

It was so shocking that everyone had a lot of questions.

Marjorie didn't care what other people thought, and asked questions on his own. From his point of view, understanding Yang Rui now has become a necessary homework.

The g-protein coupled receptor represented by Wang Qi was broken through two difficulties by Yang Rui in a row. As long as Marjorie thought of the sensation that this news would cause, he had to be more careful.

However, while talking, the scene in the backyard suddenly appeared in Marjorie's mind.

"Mr. Yang Rui, as I remember, we seem to have talked about the three-dimensional structure before? Is it the three-dimensional structure of the G protein-coupled receptor? Have you gotten involved?" As soon as Marjorie spoke, the surroundings became quiet.

The scholars present seemed to have been reminded, and they looked at Yang Rui with wrong expressions.

Think about it, if the repeated experiments on the crystal structure started a few months ago, it means that the main project ended a few months ago. For such a long time, it is impossible for the Ion Channel Laboratory of Peking University to just do repeated experiments, no Do new research.

Well, new research...

Is the new study the three-dimensional structure of G protein-coupled receptors?

A group of biologists looked up at the tall Yang Rui, feeling inexplicably looking up.