Rebirth of the God-level Xueba

【Your every click, every favorite, every recommendation, every subscription is an important encouragement and support for Zhiniao Village】

***********************************

[Rebirth God-level Scholar] Genesis Page

***********************************

[Rebirth God-level Scholar] Total serial post!

***********************************

[Signing in is the embodiment of honor and strength, I hope you don't forget to click the sign in the upper right corner while watching the update]

***********************************

Oligonucleotide is oligonucleotide, which is composed of two words, one is oligomeric and the other is nucleotide.

This word looks very complicated, but in fact, it is the Chinese scholar Wen Qingbing Fan who named it, and he gave a name that seems troublesome (I wanted to check which hero came up with such words as nucleotide, Names like guanine and cytosine didn’t find any names like guanine and cytosine. After searching for half an hour, I couldn’t find them. After thinking about it, I also did this kind of thing because of the pain of a bird’s egg...)

Nucleotide itself is a basic molecule, which is similar to dihydrogen monoxide in significance to living organisms. And its importance is mainly reflected in its composition. When the nucleotides are connected together, they are ribonucleotides, or RNA; if they are deoxygenated, they are called deoxyribonucleotides, which is DNA.

And oligonucleotides are a group of nucleotides gathered together, not many, the total number is less than 20, so the so-called oligonucleotides have become idle and useless oligonucleotides.

Of course, oligonucleotides are useless by themselves, but they are the raw material for so many biological experiments that people desperately want to produce them because they are used in too many quantities.

Historically, Murris, who won the Nobel Prize, worked as the director of the oligonucleotide laboratory of a private company. His job was to continuously synthesize and produce oligonucleotides, and then provide experimental supplies for other departments of the company. raw materials.

Michael Smith, who won the Nobel Prize in the same year as Murris, also invented the oligonucleotide site-directed mutagenesis technology.

However, Michael Smith is much worse than Murris. He made the oligonucleotide site-directed mutagenesis technology in 1979. At that time, the oligonucleotide production method used by Murris had not yet been invented. .

Therefore, Michael Smith had to spend most of his time producing oligonucleotides.

This is the normal state of researchers, who spend most of their time doing boring and repetitive work.

However, before technological development has been achieved, boring and repetitive labor is necessary, and some valuable results are also found in repetitive labor.

From 1979 to 1983, in just four years, the development speed of biotechnology was fast enough to make the Nobel Prize winners bewildered. In fact, if the textbooks were revised according to the development speed of biotechnology, it would be revised twice a year. Certainly not enough.

Biotechnology has thus entered an era similar to Moore's Law.

For the scholars in it, this is an era of pain and happiness. They study hard, work hard on projects, and personally join the wave of change in the great era. Their achievements may not be accomplished by the predecessors in a hundred years. of.

For college students who are studying, there is only pain left in this era. College students from other disciplines are still complaining,

What we learn in college is useless in society—biology college students look back at the textbooks of the past four years when they are looking for a job, and they will find that the things in them have been revised beyond recognition...

Of course, most of the textbooks are too late to revise, so that they don't even know how far behind they are.

In fact, in terms of proportion, Chinese scholars are far behind, especially in cutting-edge technology. In the era when most Chinese researchers could not understand English, it was too difficult for everyone to follow the rhythm of American dads. Can’t you see Knowing the research results and articles of predecessors, do you have to do it again?

Even if you do it all over again, you won’t be able to catch up.

Since the Americans began to allow commercial private biological companies in the 1970s, the application technology of biological sciences has been advancing rapidly, and professional terms can be redefined once in five years. If those who follow are slow to learn, they will be left behind, let alone themselves. Done.

And when Yang Rui mentioned the DNA synthesizer, not only Li Wenqiang and others from the local university didn't know, but Huang Mao, who just came back from Columbia University in the United States a few years ago, didn't have any idea either.

"Isn't it okay to make nucleotides in the laboratory? We have a lot of manpower now, and it should be no problem to deploy two people." Huang Mao has also heard of DNA synthesizers. He has no idea about the details. .

Yang Rui shook his head and said: "I have already bought the DNA synthesizer. An American company called Biological Research has been trying to produce this kind of instrument two years ago. We are already behind our competitors. After the DNA synthesizer arrives, our first task is to Transform this instrument, improve its production capacity, and then start production. Of course, the original laboratory method will continue to be used as experimental raw materials during this period.”

The current DNA synthesizer is far from the level of the later generations. Let alone the automatic production of nucleotides, it is not easy to work normally. It is necessary to modify it. Just like the early computers, users can program their own programs and add-ons and the like. It's not a big deal, and don't expect the engineers of the other company to have maintenance capabilities. The so-called first generation refers to things that no one else can understand except the developers.

However, even this kind of scientific research equipment is not something you can buy if you want. If China and the United States were not in the honeymoon period, Yang Rui would not be able to buy the equipment even if he gave him money.

Huang Mao has never seen anything before, and his focus is different. First, he asked in surprise: "Who is the opponent? You said just now that we are already behind the opponent. Who is our opponent?"

Yang Rui didn't give a direct answer, but said: "Everyone who engages in scientific research is an opponent except our own. In any case, we should first improve our own supply capacity, and we will have other uses in the future."

Huang Mao still thought it was expensive, so he asked cautiously, "How much does that DNA synthesizer cost?"

Yang Rui gritted his teeth and said, "With shipping, it's $280,000."

"hiss--"

Several people in the laboratory gasped in unison.

"No way, it's the price. When the thing comes, it may cost tens of thousands of dollars in renovation costs. So, everyone should cheer up during this time, and don't let this money go to waste. There is a new DNA synthesizer, and the old one has not been figured out, so it is really a waste."

"That's too expensive, how much faster can it be made than ourselves?"

"At least five times, debug it, modify it yourself, it's no problem to increase it to ten times. This output is also necessary, at least it must be increased to 6 people for a full day." Yang Rui is actually not willing to spend so much money, Huarui The company is a wholly-owned subsidiary of his offshore company's offshore company, and the $280,000 is all his own money. If this money is used in the Friendship Store, one floor can be sold out. If it is used to buy a house in Beijing, it can buy a hundred courtyard houses. After 30 years, at least more than one billion yuan, at least 200 million U.S. dollars, must appreciate 1,000 times.

However, it is a Nobel Prize-level research, not to mention that Yang Rui still has money, even if he spends all his money, Yang Rui will be willing to exchange for a Nobel Prize.

Huang Mao listened to the quantity Yang Rui said, looked around, and said helplessly: "The output of 6 people for a whole day is not enough for all of us to go to battle... Or, let's recruit a few more people to specialize in oligonucleotides. ? The instrument is temporarily out of use."

He still cares about money. Huang Mao is now the deputy director of Huarui Laboratory, seeing Yang Rui spend more than half of the working capital in one go, he is also helpless.

Yang Rui shook his head: "It's not impossible to build a specialized oligonucleotide laboratory, but it's too labor-intensive. 6 people produce all day, and more than 8 people have to be recruited. Adding two or three assistants, you have to prepare ten people. This is for raw materials, and there must be serious experiments. With so many people, there must be full-time management personnel, plus accountants and cashiers. The company's size has doubled at once, and there are too many problems. In addition, the production capacity of the equipment can be expanded, and the purity can be easily controlled, which are all advantages.”

The purity of the instrument is well controlled, which does not mean that the oligonucleotides produced by the instrument are more pure, but more average. For important experiments, average may be a more important concept, because it is easier to predict the progress of the experiment, and the purity of the raw material drug may not be regarded as a variable.

Anyone who has studied equations knows that a linear equation in two variables is easy to solve, a linear equation in three variables is not difficult, but a linear equation in four variables is troublesome, and a linear equation in five variables with five variables, if you cannot find a special relationship, you can It's hard to play.

For a high-demand laboratory, everyone is a different variable, and the lower the researcher's level, the higher the variable index.

The calves recruited by Yang Rui have not shown earth-shattering abilities yet, but since they can develop earth-shattering levels, at least they have good basic skills now, and then recruit researchers with different levels, and then retrain and even train them. Basic research thinking requires too much time. Although Huarui Lab is rich, it lacks a brand like Peking University. It is not easy to recruit more high-level people. A few snails.

Huang Mao asked: "Is this necessary for the project we are doing now?"

He actually wanted to ask if it was worth it?

Yang Ruixin said: This is the Nobel Prize, 280,000 US dollars, that is, the initial investment.

After calculating his own savings, after more than one year of dividends plus the extra income from Zeneca’s overseas factories, Yang Rui still has more than 4 million US dollars in his hand, which made Yang Rui say with some confidence: “Big project Let’s not talk about how it will be made, this DNA synthesizer is here, we can at least write a few papers based on it, it’s not a loss.”

"Three hundred thousand dollars for a few papers is quite expensive." Huang Mao sighed, and said, "Fortunately, foreigners have money, so let's spend it first."

Yang Rui rolled his eyes when he said it, and felt a little cold in his heart. This is still the beginning, it is the prelude to the project, and 8% of the funds have been released, which is indeed a bit dangerous.

Scientific research is a bit like doing business, and it is more difficult than doing business. Both of them care about the capital chain, but half of the business is done, and the capital chain is tight, which can be mortgaged or loaned. It is difficult to get some collateral for scientific research. There are venture capital companies in the United States that specialize in biological companies, but what they want are shares, and the asking price is high. It cannot be said to be a robbery, but in terms of price, it is almost the same as a robbery. On the other hand, the timeliness of scientific research is strong. It is normal to talk about loans and shares in business for a month or two, but it is difficult to say the result when doing scientific research after a delay of one or two months. possible.

If he can wait, Yang Rui still wants to wait, so that he can save one more quarter of dividends, at least one million dollars less. Unfortunately, time waits for no one. Be strong.

...