Rebirth of the God-level Xueba

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The DNA synthesizer used to produce oligonucleotides was delivered from Tianjin Port within a few days.

Yang Rui also confirmed the arrival of these basic equipment before starting the formal project.

Unlike the happy Murris, Yang Rui is firstly not white, secondly not American, thirdly not a member of a well-known research institution in a developed country, fourthly does not have an educational background from a well-known European and American college, and fifthly does not have a background in a large company or institution , the sixth year is too young.

Under such circumstances, if Yang Rui wants to win the Nobel Prize, he must first have excellent results.

The results are naturally very strong, but for the Nobel Prize, there is no strongest but stronger.

Secondly, Yang Rui has to be careful and step by step.

Careful step-by-step scientific research is not a multi-party verification of the results. Multi-party verification, naturally other scholars will do these things for you. The reason why you can publish papers after repeated experiments is because repeated experiments have certain value.

Careful step by step in scientific research is to publish papers in stages.

Historically, Murris and his company have published about three papers in total. They are large American companies, and publishing one paper at a large stage can prove their work.

For Yang Rui, it was not so easy.

At any rate, he still has a CELL-level thesis, which is rare in China, but internationally, this is the foundation of the stepping stone, and the effect is better than that of a PHD (doctorate) with no background.

On this basis, Yang Rui plans to publish a paper with the goal of double digits.

His reference object is the research group of artificially synthesized bovine insulin in China. Over the years, this research team has published more than 20 papers in several top journals, proving the ownership of the results with a very clear research chain, and at the same time, gradually promoting this topic.

Although the Chinese scientific research groups in the 1960s were at the national level, they faced many problems in order to prove themselves. Yang Rui now has the endorsement of his identity from Peking University, and has CELL-level papers. The degree of difficulty is about the same as that of the research group of artificially synthesized bovine insulin.

However, to form a clear scientific research chain, it is not necessary to write everything, and it is not necessary to publish papers in chronological order.

For example, on heat-resistant polymerase, Yang Rui plans to publish it at the end.

The reason is simple, there are heat-resistant polymerases, which can greatly reduce the experimental time.

It is essentially a DNA multiplication technique.

It can quickly double and double and double the DNA... In theory, it can double as many times as you want.

This is like the story of the famous standard bearer and the king.

Put 2 grains of wheat on the first square of chess, 4 grains on the second square, 8 grains on the third square, and 16 grains on the fourth square. How many grains are there in the 30th square?

—The thirty-th square will contain one billion,073,741,824 grains of wheat.

Also because of this super multiplication technique, it has shown its talents in countless fields.

For example, the DNA residue at a crime scene, before the era, the reagent residue was too small to be detected, but after entering the 1990s, the police station that has owned it can ignore the number of residues. In theory, as long as there is an intact DNA residue, it can be multiplied to a detectable state.

The reason why it was only owned by the police station in the 1990s is because of the heat-resistant polymerase.

The raw material is polymerase, and ordinary polymerase can also be used, but every time it is doubled, the heat-labile polymerase will be inactivated in a water bath of more than 90 degrees. Add polymerase once.

Not to mention that polymerase is not cheap, this process also requires professionals to do it, which is complicated and error-prone.

In the course of the research, it was not easy to add the polymerase 30 times in a row.

Of course, developing thermostable polymerases is not easy either.

Therefore, in history, Murris et al. first devoted themselves to solving the doubling problem, and did not give priority to the problem of heat-resistant polymerase.

After all, it is necessary to simplify the method only when the doubling problem is solved and it is proved that this method is feasible.

Otherwise, just having a heat-resistant polymerase without the technology to use it is useless.

However, Yang Rui is different from Murris et al.

He already knows for sure that it is a good technique.

Therefore, he is the first to do research that can improve efficiency. When it is time to release the papers in stages, even if others are inspired, they will not be able to catch up with his speed.

In fact, Yang Rui still hopes that someone can chase after him.

If a Chinese simply made a smart, simple, and world-affecting achievement, half of the evaluations he received would be "fucking luck."

But if a Chinese, in the scientific research competition where you catch up with me, makes achievements that affect the world in a smart and simple way, his evaluation will be very different.

Of course, doing so is bound to be risky. But after much deliberation, Yang Rui decided to publish papers periodically.

The reason is very simple, a simple thesis will not necessarily send Yang Rui to the altar of the Nobel Prize.

And if there is no Nobel Prize, the value of the project will be greatly reduced. Although it may still be worth 3 billion U.S. dollars, for Yang Rui, the value of the Nobel Prize is more than 3 billion U.S. dollars.

Based on this idea, on the fourth day after the DNA synthesizer was delivered, Yang Rui began to draft his first paper - "Improvement Ideas for DNA Synthesizer".

It is still a pre-order paper, and it can only be said to be the pre-order of the pre-order, but the so-called scientific research chain is linked one by one in this way.

Huang Mao and the others were very happy. They had just signed a thick legal document written by several lawyers from Hong Kong, almost giving all the rights to Sinovel, leaving only one signature right.

The Chinese in the 1980s never made money through patents or similar means. Huang Mao and others didn't care about this. What they cared about was a little more fame.

Fame naturally requires papers to be piled up one after another.

According to the DNA synthesizer commonly used in later generations, Yang Rui randomly copied some and used it on his newly bought DNA synthesizer.

The newly recruited Maverick Zhang Xuetong is from an engineering background. With the cooperation of two teachers from the Department of Mechanical and Electrical Engineering hired by Yang Rui, most of the modifications of the DNA synthesizer were easily realized. The domestic environment is like this. Refitting old instruments and synthesizing broken instruments are the mainstream. There are many scientific researchers who do not understand English, and few have a little hands-on ability.

Local tyrants like Yang Rui can only be seen in domestic academician-level laboratories.

280,000 US dollars, but it can almost catch up with the assets of the laboratory that Tang has been running for many years, that is, the academician-level laboratory is worthy of it.

However, the idea written by Yang Rui in the new paper requires not only hands-on ability, but also considerable materials and parts. Zhang Xuetong has no way to find things that cannot be found in China.

In this regard, Yang Rui has a good idea. While sending the paper to the journal, he also sent another copy to "Biological Research", the manufacturer of the DNA synthesizer.

Zhang Xuetong was a little uneasy about this, and asked, "Will this biological research company plagiarize our technology?"

"Generally no, they don't know what evidence we have left. For example, the photos I just took belong to our evidence. If they plagiarized, we can not only sue them, but also scold them in the circle... "Yang Rui said with a smile, and said: "It's not easy to be a biological company, and we are kind enough to help them improve their technology. They don't need to plagiarize this level of transformation."

"We have become an international Lei Feng." Zhang Xuetong looked a little ugly, but he had a sense of accomplishment after modifying the DNA synthesizer with more complete functions.

Yang Rui nodded slightly, but said: "It's true that we are good people, we may not live up to Lei Feng."

Zhang Xuetong frowned like a plus sign, and said: "We haven't done well enough, and the international standards for living Lei Feng are too strict!"

Huang Mao, who had been to the United States, couldn't help laughing. He and Yang Rui were already familiar, so he said, "I guess what Yang Rui meant was not to give away technology for nothing."

Zhang Xuetong was puzzled: "The technology is improved on other people's machines, so what if we don't give it away, we improve it ourselves and sell it?"

"Where do we have time to sell?" Huang Mao glanced at Yang Rui, seeing that he didn't speak, he knew he had guessed right, and said happily: "Lao Mei's current technology companies are very accustomed to this kind of technological improvement, especially The first-generation instrument, you can see that it is so expensive, it is because of the research and development cost, if the user participates in the research and development, they will get some compensation."

"Have money for it?" Zhang Xuetong instantly simplified Huang Mao's words.

Huang Mao nodded, and said: "If the improvement is important, they will discuss with us about purchasing technology, or technology authorization. This kind of trouble, such an improvement like ours, I guess it will be bookmarked."

"book?"

"The accessories booklet is just like the one we got." Huang Mao said as he took the manual in front of the machine, took out a black and white printed booklet, and said, "Look, there are all accessories here. The so-called matching, if you want to buy it, you will pay for it, and they will make it for you, the price is not cheap, often hundreds of thousands of dollars, our improvement, I guess it will also be included in the accessories booklet."

Zhang Xuetong nodded half-understanding, and said: "But we still have some technologies that have not been realized, can we just give you an idea for improvement?"

"We have a complete idea, then we can." Huang Mao said firmly: "When I was at Columbia University, several professors liked to do this kind of thing. If you make a little modification, the technology company will give you a lot of money. If you buy a Taixin instrument and use it for half a year, not to mention the smoothness of the change, you can save more than half of the money, and maybe you can make money."

"Isn't the technology company losing money?"

Yang Rui couldn't help laughing: "Columbia University is an Ivy League university. A professor at Columbia University can't be hired by ordinary technology companies. They can appreciate his equipment and help him improve it. If he still refuses to pay, The reputation in the industry will be ruined, besides, they don’t rely on the first batch of equipment to make money, and it should be the second or even third type of improved equipment that can really sell in large quantities and make money back.”

"I see. No wonder you are in a hurry to improve the DNA synthesizer." Zhang Xuetong completely missed the direction.

Yang Rui didn't care, and said with a smile: "It's good if you can get some books back, and the second author of this paper will be signed by Zhang Xuetong. You also continue to work hard to stabilize the synthesis of oligonucleotides."

It is difficult for a clever woman to cook without rice, and there is no way to do it without a stable supply of oligonucleotides.

This is also a manifestation of China's lagging behind the world in the 1980s. Today's China is similar to the Middle East countries in the 21st century. The technology industry is seriously biased, and things like oligonucleotides cannot be bought. It is not realistic to ship it from the United States, not to mention the large demand, and the continuous transportation itself is prone to unpredictable changes in raw materials.

Yang Rui now misses the convenience of studying in graduate school. At that time, as long as he had money, he would call and there would be countless biological companies rushing to deliver all kinds of materials. One of them might be opened by the teacher of the school...

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◇【To be continued. "". If you like this work, you are welcome to come to Genesis to subscribe and reward. Your support is the author's greatest motivation. ] Bring your friends (@影成@白云如沟@字书文@玉树琼花满木春)