Rebirth of the God-level Xueba

If anyone came to lobby Yang Rui, Yang Rui was ready to go back head-on.

At worst, you can also turn on the mode of "I don't listen, I don't listen, I just don't listen".

However, Yang Rui couldn't even listen to Professor Cai's words.

Cao Baoming and Wang Guohua, who will follow him, stay behind, and let the two wander around the laboratory. Yang Rui invites Professor Cai into the office.

Professor Cai did not hide his purpose, sat down, first mentioned Jingxi Pharmaceutical General Factory, and then talked about Jingxi Pharmaceutical General Factory's investment in biological experiments over the years, and then changed the subject, that is, : "Jingxi Pharmaceutical General Factory will not be able to survive. They used to mainly produce tablets and powders. Now factories in the south are opening one after another. The price is lower than their cost. The clients were snatched away. Qin Hanchi’s agent of Sanmu’s medicine was a last-ditch effort. If he failed, the thousands of workers in Jingxi Pharmaceutical General Factory and the raw material factory that served them as suppliers would all be in trouble. .”

"Do you know Qin Hanchi?" Yang Rui asked.

"I have seen it, but this time it was Lao Zhang who asked someone to come to me." Professor Cai continued to explain: "Lao Zhang is from the GMP Preparatory Committee, and he also supported you in the by-election before. In addition, several old friends from the Ministry of Health , and they all called."

Yang Rui had seen Professor Cai's extensive network when he followed Professor Cai in project and achievement appraisal before, but from the other side, extensive network also means that he has to bear the cost of making friends.

Yang Rui nodded silently and continued to listen.

Seeing this, Professor Cai said: "If you have any ideas, just tell me. If you can tell them, I will tell them. If you can't, let's discuss it together."

Then, Professor Cai smiled and said, "Although I'm here to speak for Qin Hanchi, I can also speak for you."

Yang Rui smiled bitterly: "Why does everyone think I have ulterior motives."

"kindness?"

"I asked them to supplement the safety test because I don't trust the drug Luperdin." Yang Rui said helplessly: "The research report published by Luperdin is very insufficient, and it is very risky to rashly produce and promote it in China. Big."

"Is it more risky than Chinese patent medicine?"

Yang Rui was speechless. In this discussion, he and Professor Cai are not of the same order of magnitude.

think for a moment,

Yang Rui said: "Lyperdin is used on a larger scale than traditional Chinese medicines. In addition, it is designed to be taken for a long time. Therefore, if there is a safety problem, its risks will continue to accumulate. I think , to be more rigorous, there is nothing wrong with it.”

Professor Cai stared at Yang Rui for a while, then suddenly said, "This doesn't look like your style."

"What's my style?" Yang Rui was dumbfounded.

"Go forward indomitable." Professor Cai gave his answer.

Yang Rui recalled that when he was working on potassium ion channels, he was indeed indomitable. PCR is relatively simple to do, but the follow-up lawsuit is several million, and he doesn't want a settlement at all, and he fights relentlessly, and the subtext of "go forward", isn't it a huge risk.

Yang Rui was quite ashamed. Thinking about it this way, he did have some "this moment and that moment" problems.

"Everyone is talking about me now, isn't my reputation not very good?" Yang Rui has done a lot of brushing, and he can guess how the public thinks of him.

There's never a good thing to say when "here and now" is tied to power.

Professor Cai nodded, and said: "The scale of Jingxi Pharmaceutical General Factory is also ranked first in the whole country. Qin Hanchi has been the factory director for nearly ten years, so he is not a bad person."

Yang Rui sighed and said, "I don't want to be a bad person either."

"Then let the Jingxi Pharmaceutical General Factory pass through."

"There must be a problem with Lu Bo." Yang Rui stopped talking around and around, and answered directly.

Professor Cai naturally asked a question that Yang Rui didn't want to answer further: "What question?"

Yang Rui couldn't answer.

As an antiarrhythmic drug, liperidine has a solid academic research foundation. Determining premature beats as a disease, then associating premature beats with more serious heart diseases, and then confirming that the inhibition of premature beats is beneficial to reduce the risk of heart disease—this entire academic chain is not a day or two, nor is it a person Two people do it. This is an academic research established over ten years ago with the participation of hundreds of scholars, of which Lupodine is only a star product.

Antiarrhythmic drugs are not even a drug of Liperidine. In the 1980s, almost all large pharmaceutical companies were involved in it.

And in the past ten years, during the development of many drugs, has no one questioned the entire academic chain?

Of course there is.

However, academic discussions are only academic discussions after all, and the most important issue is that there is no fundamental flaw in the antiarrhythmic theory.

Even Yang Rui cannot categorically say that the anti-arrhythmia theory is wrong.

The antiarrhythmia theory may not be wrong. In the simplest way of thinking, it is better if the heart does not beat prematurely than the heart beats prematurely. After all, premature heart beats are an abnormal physiological phenomenon after all, and if it can be treated or suppressed at no cost, it seems that it may be a good thing.

Therefore, the crux of the problem comes back to the law Bodine itself, or the safety of such drugs themselves.

So, how to prove the safety of law Bodin?

Yang Rui knew that the problem with anti-arrhythmic drugs such as Liperidine was their influence on electrical impulses.

But the words are unfounded, the Miki company made a file in a filing cabinet to prove its safety and efficacy tests.

For Yang Rui, the best way to prove it is a clinical trial, because the side effects of ryprodine are hidden, and it takes a long time to appear. Therefore, ordinary clinical trials with a small scale and a short period of time are not enough. There are even thousands of arrhythmia patients doing a double-blind test, half of them taking lyperidine, and half of them taking a placebo, which is equivalent to a large-scale clinical phase I.

Regarding Yang Rui’s experience in making deferiprone, to get a clearer answer, it will cost about 40 million U.S. dollars, and it will take half a year. Of course, the number of patients with possible heart damage must be some, Not to mention a few more people will die.

Can Yang Rui get 40 million US dollars? Of course, he can’t afford it. There haven’t been many milestone payments for deferiprone. Besides, he can’t do this if he can afford it. He has 40 million US dollars and can research a new drug.

And if you don't do clinical trials, but engage in academic debates, Yang Rui's current status is the first, and he can't compete with others.

There are also big names in the research team of Luboding. They have been working on this drug for nearly ten years, and they have memorized more information than Yang Rui has read. Even if Yang Rui can speak eloquently, it is not enough for him to have the strength to pass the FDA. .

To be fair, FDA has always been criticized for being too inefficient and too demanding, but there are few cases where the review is not strict.

There may be some incompleteness in the review of Libodin, but in terms of the concealment and slowness of its side effects, the FDA has actually done a good enough job.

The FDA may have asked all the questions that Yang Rui could ask verbally.

"The key now is not that I want to prove that there is a problem with Liprodin, but that Jingxi Pharmaceutical General Factory has to prove to me that there is no problem with Liprodin." Yang Rui lowered his eyebrows, then raised them quickly, and said: "Professor Cai, I'm sorry, I have to save your face, and I have to be responsible for my signature."

"Even if Jingxi Pharmaceutical General Factory finds more people to put pressure on it, you won't let it go, will you?" Professor Cai asked calmly.

Yang Rui nodded slightly.

"You have to know that Qin Hanchi didn't just find me. In order to pass the law, the whole factory of Jingxi Pharmaceutical General Factory is trying to find a way. And..." Professor Cai lowered his voice and said: "Their reasons are also Very filling."

"I know."

"Are you not afraid?"

"I'm afraid, I'm afraid to death." Yang Rui smiled bitterly. If he wasn't afraid, why would he call Wang Guohua and Cao Baoming over.

Even without violence, Yang Rui is actually not sure how long he can carry it. As the saying goes, it is only when you arrive in Beijing @京城 that you know the official school. The taxi drivers in Beijing @京都 will know a department-level official. Qin Hanchi himself is a department-level official, and what level can he contact cadre?

The first level of officialdom crushes people to death, and Yang Rui doesn't live in a vacuum.

However, Yang Rui asked himself, he might not be able to completely stop Lu Boding, but it would be good if he could delay for another day. Law Bo will enter China one day later, and the number of people affected by it may be tens of thousands less, and some people may survive because of it, and there will definitely be many people, so they will avoid the danger of heart damage , so as to live a few more years, perhaps more than ten years.

Furthermore, the delayed start-up of the Jingxi Pharmaceutical General Factory may also reduce the supply of Lubotin in the global market. The supply of the pharmaceutical factory is reduced, and the pharmaceutical representatives will not be so hard to promote it. The number of Boding patients may be reduced, and fewer deaths may occur. Anyway, Americans are human beings, and it is a bit too sad to die in vain from a carefully developed drug.

Professor Cai looked at Yang Rui's expression, but inexplicably felt Yang Rui's state of mind, just like the Yang Rui he saw in Tang's concentrated laboratory.

"This is still your style." Professor Cai breathed a sigh of relief.

Yang Rui looked at him.

"Your style." Professor Cai pointed at him and said, "You are going forward."

...