The Godfather of Surgery

Chapter 1081 How big a space does an office need?

NK cell reorganization has been completed. Yang Ping provided more than 100 NK cell reorganization schemes. It is impossible to reorganize them all at once. Lin Lan only reorganized the NK cells with the highest priority, and the rest will be completed in batches.

The seed cells of the recombined NK cells were sent to the cell therapy laboratory for cultivation. Compared with viruses, the safety of cells is much higher, not to mention that NK cells are the immune cells of the human body.

Human immune cells include lymphocytes and other phagocytes. Lymphocytes include T lymphocytes, B lymphocytes, K lymphocytes and NK lymphocytes, among which the number of NK lymphocytes is relatively small.

The target cells killed by NK cells are mainly tumor cells, virus-infected cells, and larger pathogens, such as fungi and parasites. They can also kill cells of allogeneic transplanted organs or tissues. The receptors on its surface can recognize the polysaccharide molecules expressed on the surface of virus-infected cells, and then mediate the toxic molecules released after activation, such as perforin, granzyme and tumor necrosis factor, etc.

Yang Ping now splits the K factor and embeds it into NK cells. This cell is named K-NK cell, which means NK cell embedded with K factor. This type of cell prolongs the survival period, and is very accurate in identifying tumor cells. It also has a much stronger killing power against tumor cells, because after the K factor is split, it becomes an antibody with a navigation function and a factor that initiates tumor cell apoptosis.

The entire process of K-NK cell therapy is very expensive, because all the steps are brand new, so it is more expensive than CAR-T cell therapy.

Why is cell therapy expensive? Because the technology is too complicated. For example, CAR-T cell therapy. The CAR-T currently on the market is autologous CAR-T, which transforms the tumor patient's own T cells to specifically kill cancer cells in the patient's body. It is a cell therapy, which is different from both small molecule drugs and traditional macromolecule drugs; it uses genetic engineering to transform cells, so it is also a gene therapy; it uses the patient's own cells to produce, which is a customized drug for individuals and cannot be mass-produced. All these determine that the technical requirements of CAR-T cell therapy are extremely high, and the natural cost is very high.

NK cell therapy is more technically complex. In simple terms, the first step is to separate a large number of NK cells from the patient's body through leukocyte separation technology; the second step is to genetically engineer the separated K cells to express chimeric antigen receptors or receptors decomposed from K factors, so that NK cells can specifically kill specific tumor cells. In this step, the genetic engineering of NK cells will use specific viral vectors to transfer embedded genes. Due to the large amount of engineering work required to manufacture NK cells, the cost of viral vectors is very high. The third step is to expand these NK cells to a certain number, that is, to culture them in the laboratory. Only after completing all these steps can the NK products be returned to the patient for treatment. Each step requires a specific laboratory to complete, and the requirements for technology and equipment are very high. The safety standards of the entire production process are very high, so the cost is also increased. In short, this kind of experiment is very expensive and ordinary people can't afford it.

Currently, three top laboratories are working together to complete this experiment. The scale of the experiment is rare in the world. Yang Ping is like a marshal commanding a large army, and Tang Shun, Lu Xiaolu, and Lin Lan are the generals under him. Yang Ping needs to coordinate the whole process and make sure that no detail is wrong, so that the experimental goal can be achieved at the fastest speed.

Now because the cell therapy laboratory needs to be expanded, the demand for buildings has increased instantly. After Yang Ping reported this to Dean Xia, Dean Xia immediately dealt with it as a top priority.

——

Conference room in the administrative building of Sanbo Hospital.

Dean Xia and several other hospital leaders discussed the expansion of the hospital. Sanbo Hospital still has an eight-story building that is empty, and the animal laboratory is now located there.

Dean Xia is planning to vacate that building for Yang Ping to use as a laboratory. The entire eight floors of the building will be used as laboratories, which should be able to alleviate the current shortage of housing. But after the building is vacated, where should the animal laboratory be moved? The animal laboratory cannot be mixed with the scientific research laboratory. Those pigs make it smelly every day, and the laboratory has very strict requirements for cleanliness and sterility.

"Don't we still have a lot of vacant land? We can build a few more buildings. Before the new buildings are built, we can find a corner to temporarily build a light steel house or board house for animal laboratories. The conditions of animal laboratories are not high. In fact, it is a pig farm with better conditions." Dean Sun expressed his thoughts. Dean Sun is now in charge of logistics.

"If the entire eighth floor is reserved for laboratories, there will be no room for the development of other departments. Sports Medicine Center, Trauma Orthopedics, Trauma Emergency Center, Oncology Department, Plastic Surgery Department, General Surgery Department, etc., there are not enough beds now. Can half of them be used for clinical departments?" Another vice president frowned.

"No, the cell laboratory has very high requirements for cleanliness and sterility. It must not be mixed with clinical departments, and it is not easy to manage." Dean Xia rejected this proposal.

"What should we do? Rebuilding the building will take more than a day or two. We never thought that the hospital would develop so fast. For example, the general surgery and plastic surgery departments are developing very rapidly now. It was completely unexpected. Director Fang and Director Lan talked to me several times, but I kept it to myself and didn't dare to give in because we have to leave the only remaining empty building to Yang Ping." Dean Sun said in embarrassment.

''The eight-story building in Yangping is estimated to be enough for the time being, and it will definitely not be enough in the future. The cell therapy laboratory needs several floors. Stem cell experiments and other cell laboratories must be separated, and there is also a clinical ward for cell therapy. , an international diagnosis and treatment center for cell therapy, a separate administrative area, etc. The laboratory in Tang Shun has at least five or six floors, and Lu Xiaolu has two floors, so there is no seventh floor. The floors here cannot be divided in any way. To other departments. "Director Han is now the deputy dean in charge of business. In fact, Director Han originally did not want to be the dean, but in order to assist Yang Ping, he reluctantly served as the vice dean of business.

"Let those clinical departments bear with it for a while." Another vice president said.

"If it doesn't work out, let's vacate all the administrative buildings. We can find an open space to build a light steel house or a simple board house to serve as an office. As for the administrative building, it only needs to be able to shelter from wind and rain. There are no hard conditions required. We will wait until the new house is built. , let’s move in again.” Dean Xia thought about it for a long time and came up with a good idea.

Dean Sun said: "If this is the case, it can be turned around temporarily."

Dean Xia waved his hand: "Then let's build the prefabricated house as soon as possible, a three-story prefabricated house, and we will have offices. Our administrative building will be all given to the clinical departments, and we will all Just bear with it, as long as you need as much space as you want for your office, a room, a desk, a phone and a computer, it’s not too demanding.”

Tap the screen to use advanced tools Tip: You can use left and right keyboard keys to browse between chapters.

You'll Also Like