The Godfather of Surgery

Director Zhao calmed down this minor disturbance with a basket of eggs. As the director of the Medical Department, he had to face various complaints, disturbances, disputes, etc. almost every day. He had been through many battles and was experienced, and he knew how to deal with any matter.

He was too lazy to explain and persuade people for things that could be solved with a basket of eggs, wasting time, and was too lazy to ask the security guards to solve it forcefully, it was not worth it. The young staff learned experience from Director Zhao, and a disturbance that seemed difficult to deal with was resolved by Director Zhao lightly.

The first PET-CT of the experimental pig has been completed. Because of the Internet connection, the picture quickly appeared on the electronic film reader in the laboratory, and the image of NK cells with special markers was scattered on the image.

Of course, Tang Shun and Lu Xiaolu could not read the film, so they could only listen to Yang Ping's explanation on the side. Hearing that the picture had come out, Yang Ping came to the laboratory.

Sure enough, compared with the K virus that needs to experience a lot of loss of the immune system, NK cells, as their own cells, are unimpeded in the experimental pig, quickly spread in the blood throughout the body, and then slowly gather towards the tumor.

But there is also a problem. The distribution of NK cells is consistent with the distribution of blood vessels in the experimental pigs. Even inside the tumor image, it is consistent with the distribution of small blood vessels and capillaries. It is difficult for them to break through the blood vessel wall and enter the body fluid between tumor cells.

"Look, are these images formed by the gathering of NK cells? It seems that the tumor is covered?" Tang Shun can also see something through intuitive observation.

Lu Xiaolu also came over, and it seemed to be the case. The image of NK cell gathering covered the tumor.

Yang Ping shook his head: "Many NK cells are in the blood vessels, and some of them penetrated the capillary wall and came to the gap between tumor cells, but whether they can play a role is still unknown."

In fact, some cells can pass through the capillary wall, such as white blood cells, because white blood cells can deform and move. When there are bacteria somewhere in the body, white blood cells will pass through the capillary wall to engulf the bacteria, and NK cells are a type of white blood cells, so NK cells can also penetrate the capillary wall and wander in the gap between tumor cells. However, the penetration of NK cells into the capillary wall does not mean that they can approach tumor cells, because tumors have their own barriers, which are obstacles that prevent NK cells from contacting tumor cells. This is also the reason why cell therapy is not good for solid tumors.

However, this is only the first imaging examination, and there will be many imaging examinations in the future. In addition to imaging examinations, there are many other examination items.

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Another topic of cooperation among several major laboratories is to implant certain gene fragments of immune cells into carrier adenoviruses. Although it is not clear whether K factor is really formed by the recombination of gene fragments of immune cells, in order to carry out research as soon as possible, they have taken the hypothesis as true and recombined the genes of the two.

If the research is carried out according to this idea, the space for operation is much larger than the original K factor combined with carrier adenovirus. Not only can certain gene fragments on immune cells be used to arm the virus, but also camouflage it. This camouflage is long-lasting and can help the virus avoid the attack of the immune system. The attack of the immune system is weakened, and the adaptive self-change of the virus to the immune system is naturally weakened. In theory, the new virus recombined in this way can escape the attack of the immune system.

Viruses are both the enemy and the old friend of mankind. It is a special relationship of both enemies and friends. Viruses are non-cellular organisms that must parasitize and reproduce in living cells. They are extremely small, between life and non-life, and have no metabolic structure of their own. The structure of viruses is simple, and they are nucleic acids wrapped in proteins. They can replicate and reproduce rapidly in host cells, that is, viruses must parasitize in host cells to survive.

The word "virus" comes from Latin, which means snake venom or human semen. In other words, it is given the meaning of "destruction" and "creation" at the same time.

People usually think that it is not a good thing and has a certain degree of destructiveness. As long as it breaks through the human immune system and infects the human body, people will get sick and die. Whether it is the flu virus that gives us headaches and runny noses, or various other more serious infectious viruses, once they infect the human body, they will bring disease or death to the human body. This is its destructiveness.

As for its other side - creativity, it actually exists, but we know very little about it. Viruses also contribute to the habitability of the earth. Ocean Synechococcus contributes a quarter of the oxygen on the earth through photosynthesis. The DNA that really works in Synechococcus comes from the genes of viruses. According to scientists' estimates, 10% of photosynthesis on the earth can be attributed to viral genes. They not only contribute oxygen for us to breathe, but also regulate the temperature of the earth.

Viruses are also very close to our human body. 8% of the DNA fragments in the human body come from viruses. Under certain conditions, these viruses may still be reactivated. On the other hand, when our cells make new viruses, they may also insert their own DNA and then transmit genes in other hosts. Looking back at ourselves from the perspective of viruses, organisms are essentially just a bunch of DNA that is constantly mixed and transferred.

According to the ideas given by Yang Ping, three tasks need to be done: split and study the functional gene fragments of immune cells, study the most suitable virus vectors, and study the structure of viruses that have coexisted peacefully with humans. Only after these three issues are clarified can this topic be considered to have touched the door.

The breadth and depth of the research on these topics are unprecedented. In the face of these grand topics, Professor Zhang Zhiwei feels that the topics he studied before are simply children playing house.

If in the past, Professor Zhang Zhiwei would not dare to think about carrying out such a grand research, let alone his imagination and strategic judgment ability could not reach this level. Even if the scientific research plan was placed in front of him, he would definitely not dare to accept such a task.

The funding for this kind of project is huge, and all the research funds gathered are just a drop in the bucket. The time span is also amazing, and it is likely to fail in the end. Even if Professor Zhang does not worry about the title, no researcher under him will follow him to do this kind of project, because it is impossible to obtain output in a short period of time. If there is no output of papers, the title cannot be evaluated. It is difficult to gain a foothold in the academic world without papers and titles for a long time. Besides, if Yang Ping didn't have his own funds, if Professor Zhang Zhiwei applied for the project, it would most likely fail to pass the expert review, because the review experts couldn't understand this kind of project at all, and in the end they would definitely sneer at it and judge it as wild and boastful.

But now it's different. With Yang Ping's strong financial support, Professor Zhang Zhiwei doesn't need to consider too many problems. He just needs to study slowly at the pace and doesn't need to worry about whether he can succeed in the end, because most of the explorations of the unknown end in failure.

Looking back at the history of medicine, many innovations that seemed absurd and incomprehensible at the time were finally proved to be wrong, but mistakes do not mean meaningless, and correctness is generated from the accumulation of these mistakes.

Not only medicine, but the development of any science is like this. Aristotle believed that force was the reason for maintaining the movement of objects. This wrong judgment lasted for two thousand years and was later corrected by Galileo and Descartes. They believed that force was not the reason for maintaining movement, and objects could maintain movement without the action of force. At that time, this was just a rough hypothesis, and they only obtained this conclusion through ideal experiments. Later, Newton proposed Newton's first law based on their research.

Therefore, in science, any new theory is imperfect at the beginning. It is rough, may contain errors, and may even be completely wrong. However, even if it is completely wrong, it has inestimable value. It provides experience for later generations and has a basis for research.

Lin Lan's genetics laboratory began to draw a gene spectrum for the K factor. At the same time, it also began to draw a gene spectrum for various immune cells in the human body. After the gene spectrum of the two was drawn, they were compared to see if they had overlapping fragments. If there were overlapping fragments, what were the overlapping fragments.

No mistakes, one post, one content, one 6, one 9, one book, one bar, take a look!

If it is found that the fragments of the K factor can be found overlapping in immune cells and immune factors, then Professor Yang's hypothesis is true. For a genetics scholar, completing this project is enough to reach the top of the pyramid of the world academic community.

On Lin Lan's side, both the researchers and the equipment are obviously far from enough to be competent for this big project. On the second day after the meeting, before her budget was released, Yang Ping's research fund transferred 500 million yuan to their laboratory account as a prepayment. If the budget was not enough, they would pay more.

With this money, Lin Lan felt relieved. Now, whether it was talent allocation or hardware equipment, she was planning towards the goal of building the world's top genetics laboratory, and she was determined to build the genetics laboratory of Nandu Medical University into a world-class laboratory.