Ultimate Scholar
Chapter 225 The surprise effect of RSCA, the important flaw of PEFF
With Li Mu's thought, another real blood vessel model appeared in front of him, and then, with his thought again, a very serious thrombus appeared in the deep vein of the lower extremity of this real blood vessel.
And the deep vein thrombosis of the lower extremities, once it falls off, will travel in the body veins, and eventually it will easily lead to severe pulmonary embolism, in addition to causing various diseases.
Therefore, this can be regarded as a very high-risk thrombosis situation.
Then, in the simulated world, Li Mu's people appeared, and a syringe appeared in his hand.
The drug in the syringe is RSCA liquid.
In the simulation of the real cosmic environment, although as long as the subject of the experiment is determined, no other experiments can be carried out. \b
For example, now that he has determined that the subject is the fluid mechanics analysis of blood vessels, he can no longer study how to synthesize new drugs.
Still, he was able to test the effects of various thrombolytic drugs in this experiment.
As long as he knows the chemical composition of these thrombolytic drugs.
It's a small loophole that can be exploited.
As his thoughts moved again, the body of the simulated human in front of him reappeared from the transparent state, and then he found the buttock injection area for subcutaneous injection.
After the injection was completed, Li Mu began to speed up the time in the simulated world, while paying close attention to the blood clots of the simulated human.
Just a few seconds passed, but after ten minutes actually passed, Li Mu observed that the thrombus in the deep veins of the lower extremities gradually began to disappear.
Plasminogen is activated, allowing the fibrin in the thrombus to be dissolved quickly. Even if it has not been dissolved for the time being, after the attachment of the RSCA component, the fibrin becomes smoother and is no longer easy to communicate with the platelets. Formation of blood clots.
The blood vessels are unblocked again.
Li Mu showed admiring eyes.
Such a thrombolytic effect is indeed very good.
At least it was much better than the 123-generation thrombolytic drug he had used before.
Prior to this, he had tested the effect of previous generations of thrombolytic drugs.
As far as the current effect is concerned, these generations of thrombolytic drugs are not as good as their RSCA.
Of course, the most important thing is that RSCA can be applied to many different thrombosis symptoms.
Unlike several other thrombolytic drugs that specifically target thrombosis symptoms, for example, alteplase is mainly used to treat acute myocardial infarction and pulmonary embolism.
After observing for a while, Li Mu discovered something quite pleasantly.
RSCA has a very unique specificity of thrombolysis, so it basically does not cause additional bleeding symptoms.
Other thrombolytic drugs will increase the activity level of plasmin in the body, which will cause plasmin to dissolve the fibrin outside the thrombus, such as the fibrin of the blood vessel wall cells, resulting in blood vessel rupture and bleeding symptoms.
This is a common complication in the process of thrombolysis. Once it is serious, such as cerebral hemorrhage, it may lead to the death of the patient.
Now, according to Li Mu's simulation, the specific recognition of RSCA can almost allow it to only recognize the plasminogen in the thrombus, so that it can be excited into plasmin without dissolving the cell wall.
This means that even those patients who are prone to bleeding will be able to use RSCA!
Ordinary patients don’t have to worry about the possible bleeding complications after using RSCA!
He opened his eyes and looked at Kingsley Weir next to him.
"well-done!"
Hearing the boss's encouragement, Kingsley Weir, who was still a little confused about why Li Mu suddenly closed his eyes, showed a smile on his face.
"Of course! I said it at the beginning, you will not regret it, and this is also my promise."
Li Mu smiled, then lowered his head, and flipped through the report in his hand again. In the report, it didn't say that RSCA also has the effect of preventing bleeding complications.
He said: "It seems that you still don't know that RSCA has a very important function."
Kingsley Weir was taken aback, "What effect?"
Li Mu explained this role.
Kingsley Weldon was stunned for a moment. How did Li Mu find this out after reading the report?
He asked suspiciously, "How do you know this?"
Li Mu smiled. Of course, he couldn't tell the actual reason, but after observing the "result" in the computer in his mind, at this time, he can analyze such a result through data analysis.
The method is very simple, only need to analyze the blood fibrinolysis level in the data.
So he took paper and pen from the side, and after some simple calculations, he got an obvious result.
"...So, RSCA has a more unique specificity, which can avoid mislysis of fibrin."
Seeing the results of Li Mu's analysis, Kingsley Weir's eyes widened in an instant, with excitement written all over his face: "You mean...you mean...we also solved all the problems along the way. Complications of suppository drugs?!"
"Yes." Li Mu nodded.
"Great gift crab special!"
Kingsley Weldon jumped up and down in the room excitedly.
He knows all too well what that means.
This also means that patients with thrombosis who had to undergo surgery to remove the thrombus due to bleeding symptoms in the body or prone to bleeding can now use their RSCA!
In this way, the possible patient customer base is expanded for them invisibly.
Thinking of this, Kingsley Weir couldn't help being happy.
Hey, so what if that guy Skarner Slavi is ahead?
After all, it is just an ordinary fourth-generation thrombolytic drug, so how can it compare to their RSCA?
Suddenly, after thinking of Skana Slavi's fourth-generation thrombolytic drugs, Kingsley Weir suddenly became quiet again. After thinking for a while, he said to Li Mu: "Boss, can you Through data analysis, we can analyze that fellow Slavi, does their thrombolytic drug have any side effects?"
"Do you have their experimental data?"
Li Mu glanced at Kingsley Weir.
"Uh... not specific about this, but they posted the paper on "Cell", can you see if you can analyze some problems?"
As he spoke, Kingsley Weir took a magazine from the side, which was the latest issue of "Cell".
Soon he turned to the paper published by Skana Slavi's team.
It is about their introduction of the 4th generation thrombolytic drug PEFF. \b
The active ingredients of any drug are public, as long as a patent is applied for. As for clinical practice, it generally does not conflict with patents, so any new drug will first apply for a patent and then go into clinical practice.
Only the specific preparation process and proportion of excipients will not be disclosed.
Afterwards, Li Mu took it over and began to read it.
Soon he knew the specific composition of this PEFF from the paper.
He raised his eyebrows. For him, as long as he knew the specific ingredients, he could simulate them in the calculator in his mind.
Then, the mental calculator can deduce the actual effect.
So, he closed his eyes again.
Kingsley Weir, who was next to him, saw that Li Mu closed his eyes, and immediately thought that he must have started mental calculations again.
For a moment, he shouted in his heart: "Boss, quickly use your invincible analysis ability to analyze the shortcomings of this PEFF!"
At the same time, Li Mu has already entered the simulation and started to simulate the effect of PEFF.
With the injection of PEFF, time accelerated, and after about 20 minutes actually passed, the thrombus in the simulated patient's body began to show signs of dissolution. Of course, in terms of speed, it was not as fast as RSCA.
"However, compared to the third-generation thrombolytic drugs, it is still quite good."
Li Mu narrowed his eyes, thinking for a while.
PEFF can be valued as much by Pfizer, and naturally it is not a simple drug.
But as time passed, he suddenly noticed something different.
"Huh? There seems to be something wrong with the platelets..."
"The activity of platelets is abnormally increased to a certain extent. Although it is not too high, it just increases the risk of thrombosis recurrence..."
Li Mu's eyes narrowed immediately.
He recalled the data listed in that paper again in his mind.
It seems true that there is a certain increase in the viscosity coefficient of the blood, but it is not obvious.
Of course, even if it is not obvious, it should not be underestimated, because thrombus is formed little by little.
I just don't know whether this happened on purpose or accidentally by that Skarner Slavi.
If it was intentional, it would be terrible.
The blood clots kept recurring, and their drug was able to be sold over and over again.
This is of course scary, but it's also scary that they can actually control the properties of the drug.
If you're not careful...
Li Mu opened his eyes.
Kingsley Weir looked at him expectantly: "Boss, how is it?"
Li Mu said: "It's hard to say."
Kingsley Weir was taken aback: "Why is it hard to say?"
Li Mu told Kingsley Weir about the increase in blood viscosity: "I suspect that this may be caused by the increased activation of platelets."
"That is to say, after using their drugs, it is very likely to cause repeated recurrence of blood clots."
Kingsley Weldon was taken aback for a moment.
"What?! Is there such a thing?"
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