Ultimate Scholar

When Kingsley Weir heard Li Mu's words, he was immediately stunned.

After thinking for a moment, he exclaimed again.

"They actually have the ability to research the effect of this medicine?"

Obviously, in Kingsley Weil's view, the side effect of PEFF was intentionally caused by Pfizer.

There are many medicines in the world that can treat the symptoms but not the root cause, but there are very few medicines that can treat the symptoms while exacerbating the severity of the root cause.

This kind of medicine is simply the favorite of all pharmaceutical companies.

So, the scary thing about this is that Skarner Slavi was able to produce this drug, and his research and development capabilities are really a little too abnormal, right?

Actually developed a drug with a directional effect?

Li Mu also guessed why Kingsley Weir was so surprised. He waved his hands and said, "It's not necessarily that they did it on purpose. Maybe they didn't even think that PEFF has such an effect at all."

No matter how you think about it, with the current research methods of human beings, it is still very difficult to develop drugs with targeted effects, so it should be that Skarner Slavi accidentally made it.

He thought for a moment, then re-entered the simulation, and created a bunch of patients with pulmonary embolism and acute myocardial infarction.

Then, he injected PEFF into these simulated patients respectively, and then began to speed up time to observe their physical changes.

After the injection of PEFF, the vascular blockage of these patients was more or less relieved, and as the blood flow became smooth again, the pulmonary embolism and acute myocardial infarction were resolved to a certain extent.

However, with the acceleration of time, Li Mu discovered that the blood of some patients showed signs of atherosclerosis, especially some of the simulated elderly patients, which was the effect of the increased activation of platelets.

And as the accelerated time passed, Li Mu suddenly noticed that one of the elderly patients had a serious cerebral infarction, and within less than forty minutes, he died directly because he did not receive treatment.

Li Mu frowned immediately.

interesting.

He only simulated 20 patients here, and only one case had such a serious situation.

What's more, the conditions of the patients he simulated are quite ideal, and the physical problems are relatively simple, while the real diseases of the patients are more complicated. \b

Maybe both cerebral infarction and myocardial infarction can occur together.

However, thrombolytic drugs are specially used to deal with such diseases.

After all, compared with interventional therapy, interventional therapy has relatively high requirements for doctors’ skills, and the cost of surgery is also very high. However, thrombolytic drugs only need to be injected into the body, and thrombolysis can be achieved by relying on the circulation mechanism in the body. , and are more easily accepted by patients.

Therefore, once Pfizer encounters such a problem during the clinical trial, and even directly leads to the death of volunteers in the clinical trial, whether their new drug can pass the review of FDA and EMA is a huge problem.

FDA and EMA are the drug regulatory agencies in the United States and Europe. Any drug that wants to enter the market in these two regions needs to pass the audit of these two organizations, and these two regions are the most developed regions in the world. The regions with the most developed markets, as long as they pass, will bring huge profits.

However, it is very difficult to pass the audits of these two management organizations, especially the FDA is the most stringent and authoritative drug regulatory agency in the world.

Including Huaguo domestically also recognizes the FDA certification to a certain extent. Generally speaking, as long as the drug has passed the FDA's approval, it is relatively easy to pass Huaguo's QS certification.

And although Pfizer is well-known all over the world, the power behind it is also great, and there are also people from them in the FDA committee, but if PEFF is found to have such a big hidden danger, whether it can pass the review is a problem, after all , FDA also has people from other pharmaceutical companies.

Thinking of this, Li Mu opened his eyes again, and looked at Kingsley Weir next to him.

Although he had simulated a lot of things just now, the actual time that passed was less than a minute.

He already knew the result of PEFF, so now he doesn't care anymore.

"Okay, we don't have to pay too much attention to PEFF."

"Trust our RSCA."

Kingsley Weir came back to his senses, then sighed and said, "Of course I believe in RSCA, mine is Pfizer after all."

The world's largest pharmaceutical company, an absolute giant, in reality, everyone should be in awe of it.

Li Mu said with a smile: "You don't have to pay too much attention to this point. There is a poem in Huaguo, which is called: He is strong enough to let others be strong, and the breeze blows the hills. He is strong enough to let others be strong, and the bright moon shines on the river."

"We just have to do our own thing."

Hearing Li Mu's words, Kingsley Weir let out a long breath, then nodded heavily: "You're right, don't worry about it."

"Well, that's right."

Li Mu nodded.

...

In the next period of time, Li Mu continued to stay in Germany, using the simulation function of the computer in his mind to help Kingsley Weir and their next research.

Just like any drug requires active ingredients and auxiliary ingredients to work together, the real universe environment simulation, although it is impossible to study the preparation process because the subject has been determined, but he can directly test, the active ingredients What kind of ratio with auxiliary ingredients, the comprehensive effect is the best.

For a while, their research speed also became very fast. Kingsley Weir and the others were all amazed at how Li Mu did it, and Li Mu often only used one reason to explain it, and that was data analysis.

And he often gives the process of data analysis - after all, he already knows the answer, and it is not too simple for him to follow the answer to give the process of data analysis.

So, just like that, Kingsley Weir and the others regarded Li Mu more and more as a god-man, and his data analysis methods were also increasingly believed by them to be the guidance brought by the god of biomedicine.

Of course, while helping them analyze, Li Mu did not forget to continue the fluid mechanics analysis of blood vessels.

As such a long time passed, he also sorted out a lot of results.

For now, the most prominent achievement is that after measuring blood pressure and blood viscosity, it is possible to directly determine whether there is any blockage in the blood vessels in the human body, and to directly determine where the blockage is located. The accuracy rate is as high as ninety percent.

This achievement alone is already of great significance, which means that for doctors, when faced with a patient who is suspected of having vascular disease, but it is not clear where the problem is, they can let the patient first. Go draw blood, measure blood pressure, and then calculate which part of the problem may be based on Li Mu's results, so as to directly determine where the problem is and whether it is serious.

In addition to this point, Li Mu's results have a higher probability of judging whether there are blood circulation problems such as atherosclerosis in the patient's body. \b

Although these achievements cannot help cure diseases, they can still save lives. To determine what disease the patient is suffering from in time is of course saving lives!

This is the significance of Li Mu's research.

In this way, time passed quickly, and December came.

【Hk={(f, g)|∑|α|≤κ……】

At the end of the scratch paper, I wrote down the last line of formula.

Li Mu frowned slightly.

"Fluid...fluid..."

After analyzing and studying the fluid mechanics of blood vessels for so long, his understanding of the fluid mechanics as a whole has reached a level beyond the reach of ordinary people.

"Fluid is defined as a material body that cannot resist shear stress. As long as shear stress is applied to a certain fluid, the fluid will continue to deform..."

"So the shape of the fluid is always the same as the container, just like the blood in the blood vessel, and obstructions such as thrombus will cause the shape of the fluid, the blood, to change."

"However, in the current mathematical community, there are always different analyzes and models for different fluids."

"So is there such a fluid analysis method that can describe fluids in all different situations?"

Li Mu was thinking.

The most complicated point in the study of fluids is that there are too many forms of fluids.

The liquid in the pipe is one kind, the fluid in the river is also one kind, or the fluid between two flat plates is also one kind.

Therefore, researchers often can only discuss fluids in different situations separately.

Ever since, there has never been a unified analysis method to include all these situations.

Therefore, this question made Li Mu think: "This is very uncomfortable."

As a researcher of blood vessels—or pipeline fluids, he has always wanted to expand from pipeline fluids to other fluid modes to achieve a unified analysis, but he always failed in this regard.

"No...not right..."

Suddenly, Li Mu came back to his senses, "I've always thought about unifying different external environments, but I haven't thought about how to unify fluids!"

"What if I ignore the external shear stress and just consider the shape of the fluid?"

"The external shear stress is directly considered as the internal force of the fluid, and the fluid is directly considered as a whole..."

The research for such a long time has turned into a sudden realization at this moment.

In an instant, Li Mu found a bright road leading to the key.

"It should be so! Just like the Navier-Stokes equation, it is a unified analysis of all fluids, so if I want to prove the existence and smoothness of its solution, then I must first find any fluid in different shapes , there are commonalities..."

"Differential geometry... smooth manifolds!"

"Yes, it's like the Ritchie flow, or any other manifold, no matter how the fluid changes, it's just a topological space."

Li Mu's eyes gradually brightened.

"Treat the volume of the fluid as a space, and that's it!"

Almost at the moment when his thoughts flowed freely, Li Mu picked up a pen and began to write on the draft paper.

After only a moment, he burst out laughing.

"This is the most suitable space for studying fluids!"

"Call it from now on, Li's Space!"