Rebirth of the God-level Xueba

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When Yang Rui described it to Professor Jiang and Academician Zhu, he understated it, but in fact, he knew that the research on using bovine rhodopsin as a G protein-coupled receptor was at least three s papers away from the current mainstream scientific research direction.

The first top-level paper is to sequence the adrenergic receptor gene; the second is to sequence the bovine rhodopsin; the third is to discover the amino acid sequence of the adrenergic receptor gene and the g protein-coupled receptor , have a high degree of similarity.

This whole process actually has a certain probability.

What if Kobilka hadn't done the sequencing of the adrenoreceptor gene? What if no one happened to sequence bovine rhodopsin? What if no one is free to compare the amino acid sequences of the two?

This is actually a layman's question.

These three probabilistic questions are like asking, in a siege battle where heavy troops are assembled, what if no one captures the hills ahead, what if the enemy's heavy artillery group is not destroyed just in time, what if the time is not exactly the same manage……

G protein-coupled receptors are fighting meat-cutting battles, and there are not so many. Why, Kobilka didn't do the sequencing of the adrenal receptor gene? It didn't take long for someone to do it.

It may be a year or two later, but not too late.

What if no one is doing the sequencing of bovine rhodopsin? This is like asking what to do if the three-hour artillery preparation is not enough, and if it is not enough, it will be bombed for another three hours!

So many labs spent so much money, but they all ended up working in vain. They didn’t even leave a name. To do adrenaline receptor gene and bovine rhodopsin labs is just to choose the right target. That's all.

There are more soldiers charging, and there will always be some who survive. It's not that the enemy's machine guns are slow to sweep, and it's not that you have special gun dodging skills, but that there are enough people blocking the holes on your own side, and your dog's life is big enough.

Of course, Yang Rui is not going to be cannon fodder.

Therefore, he sacrificed the bovine rhodopsin protein.

This is a secret that Europe and the United States have only recently discovered.

Scholars who read the literature relatively quickly, probably only saw it.

If Yang Rui hadn't searched for it from time to time, he might not be able to see this information in a year or two.

a year or two,

I am already very nervous about other scientific research projects, and in terms of g protein-coupled receptors, it is almost equivalent to giving up completely.

This is also a difficult part for scholars in third world countries to do scientific research. If they are in the United States or Europe, especially in a region where a certain project is well done, the fluency of information is much better, and there are more exchanges between scholars between regions. , although it is not updated in real time, it will not be too slow.

Especially compared with laboratories in backward regions and countries, the time difference is very decisive.

For another domestic laboratory, if it finds itself two years or one year behind the international mainstream scientific research results, will it still participate in such fierce scientific research competition? Most will choose to back down.

After all, funds are limited and cannot be wasted like this.

Also closely related to funding is the timing and timing of paper publication.

According to the prejudices of countries and regions, European laboratories are the laboratories that can produce the most results. There are a large number of laboratories that have honed their swords in ten years. The tendency to communicate, and the independence and authority of scientific researchers can be relatively guaranteed, so holding back for three to five years or even seven or eight years is not too much trouble.

In comparison, laboratories in the United States are not so suffocating. Sometimes, for funding, laboratories can't wait to publish results.

For example, the relationship between bovine rhodopsin and adrenergic receptor genes. If this result is not published, it may be one or two years ahead of other laboratories—of course, it may be one or two months.

It also depends on the requirements of the laboratory for the results.

If the goal is to publish S-level papers, then the relationship between the two is good enough, and if the goal is achieved, it is natural to publish papers without hesitation.

But if the goal is to achieve a Nobel Prize-level achievement, it is considered a risk, and it may have to wait until it is published-the benefits of large funds, wide sources, and few restrictions are usually reflected in this.

As far as reality is concerned, the publication of the relationship between bovine rhodopsin protein and adrenergic receptor genes also represents that the research on G protein-coupled receptors has entered a new field.

Most of the laboratories stepped into the same starting line again.

The cruelty of scientific research competition like a meat grinder is nothing more than this. No matter how deep your previous efforts are, as long as one person publishes the results before you, everyone has to start all over again.

However, Su Xiankai and others obviously haven't felt the cruelty of scientific research competition, especially the cruelty of the world's top scientific research competition.

A few of them looked at the document while chatting and laughing, and threw Yang Rui two little flattery by the way as encouragement.

Xu Zhengping, who was the oldest, also looked at the three of them with an optimistic smile. He wasn't going to participate in this project, but that didn't hinder his expectations for the project.

Only when the ion channel laboratory is well developed can the groups in the laboratory live well, which has been proven long ago.

Yang Rui would not hit them, let them be happy for a while, and said: "Now that the goal is clear, we will follow the direction that the predecessors have pioneered. The first step is to extract the bovine rhodopsin protein. Who to do it?"

The three looked at each other, and Su Xiankai said, "I'll be the striker."

"Then leave it to you. I want a large amount of bovine rhodopsin protein, and it must be purified cleanly."

"Leave it to me." Although Su Xiankai felt a little pressured, he still agreed. There is no 100% guarantee for this thing, I can only say that I will do my best.

Yang Rui also confirmed the beginning of the project.

As the person in charge of the project, his instructions are enough up to this point, and how to extract the bovine rhodopsin protein in the future needs to be considered by Su Xiankai himself.

It was like a siege battle. Yang Rui wanted to capture a fortress in the forward position. He didn't need to describe the tactics of attacking and killing the fortress in detail, that was the responsibility of the frontline commander.

Su Xiankai is the current frontline commander, and he doesn't need to charge alone, the selected scientific research dogs in the room are all used to charge him. Only when it came to a difficult point, a critical point, or when it was really impossible to attack the front, did Su Xiankai himself come forward.

Regarding the work of Fan Zhenlong and Wang Sisheng, Yang Rui thought for a while, and said: "Now you can accompany me to read the literature, and then do a few sets of repeated experiments, choose a few g protein purification, gt, gs, gi and the like are all fine. .”

Fan Zhenlong and Wang Sisheng opened their mouths, but in the end they could only nod helplessly, keeping their ambitions in their hearts, and started with practicing basic skills.

Peking University's ion channel laboratory is still not a world-class laboratory, not only because of insufficient funds and equipment, but also because of insufficient accumulated scientific research background.

Fan Zhenlong and Wang Sisheng had never done g protein purification before, so on this battlefield, they were equivalent to frontline commanders who had never conducted siege warfare, and it was a helpless choice to spend precious money and time.

In fact, Yang Rui himself has never done g protein purification. The complexity of this work has exceeded the scope of master's or ordinary doctoral students. However, Yang Rui has now transcended the role of a frontline commander, and in the In the position of campaign commander, Yang Rui is already experienced.

Even in the meat-grinding battle, Yang Rui is not in vain.

With a budget of 6 million US dollars, three active-duty calves with great potential, and another three calves who have not yet been used as reserves, it is purely for resources, and Yang Rui feels that he has a chance to fight Taierzhuang.

In all bloody battles, until the end, the competition is all about perseverance and willpower. Presumably, the team that can see the dawn will always take advantage of it.